An estimated 10-15% of people aged between 70 – 85 years will experience depression at some point in time. Symptoms of depression are often incorrectly attributed to ageing and subsequently remain undetected and untreated. In older people, untreated depression is associated with a wide range of poor health outcomes, including an increased risk of dementia, social isolation, loss of quality of life and a shortened lifespan.
New evidence suggests that inflammation may play a role in depression in older people. However, it is not known if this inflammation contributes to the onset or the severity of depression, or if it is a by-product.
Aspirin has a well-known anti-inflammatory action. With the large number of people enrolled in the ASPREE, for the first time, researchers in the ASPREE-D sub-study will be able to determine whether aspirin can prevent depression in older people.
What does participation involve?
The ASPREE-D sub-study involves ASPREE participants answering a few questions about their history of depression and completing a measure of depression called the Center for Epidemiologic Studies Depression Scale (CES-D)-10 item scale at annual study visits. The (CES-D)-10 is a screening tool that may indicate possible depression; only a qualified medical practitioner can make a diagnosis.
Researchers will also examine blood samples in the Healthy Ageing Biobank for the presence (or absence) of proteins or ‘biomarkers’ associated with inflammation. They will then be able to determine the relationship between these inflammatory ‘biomarkers’ in the blood and diagnosed depression.
The ASPREE-D (Depression) sub-study is being undertaken in Australia and the USA.
Please note, it is recommended that anyone who suspects that they may have depression should visit their GP.
For more information about ASPREE-D:
Ring 1800 728 745 (toll free from a landline)
For more information about depression in older people:
Download this brochure or visit the beyondblue website
Collaborators:
- Monash University (Australia)
- Deakin University, School of Medicine (Australia)
- Rush University Medical Center, Department of Family Medicine and the Rush Alzheimer’s Disease Center (USA)
- University of Melbourne, Department of Psychiatry and School of Public Health and Preventive Medicine (Australia)
- Orygen Youth Health Research Centre (Australia)
- Erasmus Medical Center, Department of Immunology (The Netherlands)
- Florey Institute of Neuroscience and Mental Health (Australia)
- GP Co-investigators
Funding:
- NHMRC grant 1081901 $768,000