PUBLICATIONS

Health related data collected in the ASPREE project continues to make important scientific contributions to improve the health of older adults today and in the future.

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Publication Key words
Downie JM, Riaz M, Xie J, Lee M, Chan AT, Gibbs P, Orchard SG, Mahady SE, Sebra RP, Murray AM, Macrae F, Schadt E, Woods RL, McNeil JJ, Lacaze P, Gala M. Incident Cancer Risk and Signatures Among Older MUTYH Carriers: Analysis of Population-Based and Genomic Cohorts. Cancer Prev Res (Phila). 2022; May 31, doi: 10.1158/1940-6207.CAPR-22-0080. cancer, colorectal, CRC, PRS, genetics, genomic, genome, carriers, genotyping, variant, DNA, genetic testing, MUTYH, biobank, sub-study, substudy
Collyer TA, Murray AM, Woods RL, Storey E, Chong TJ, Ruan J, Orcahrd SG, Brdotmann A, Srikanth VK, Shah RC, Callisaya ML. Association of Dual Decline in Cognition and Gait Speed With Risk of Dementia in Older Adults. JAMA Netw Open. 2022; May 31, doi: 10.1001/jamanetworkopen.2022.14647 [epub ahead of print]. Accompanying EDITORIAL 2022; May 31, doi: 10.1001/jamanetworkopen.2022.14654. dementia, cognitive, cognition, neurological, cognitive decline, 3MS, 3ms, COWAT, HVLT-R, SDMT, gait, walking
Hu Y, Carr PR, Liew D, Broder J, Callander EJ, McNeil JJ. How does the onset of physical disability or dementia in older adults affect economic wellbeing and co-payments for health care? The impact of gender. BMC Health Serv Res. 2022; May 25, doi: 10.1186/s12913-022-08017-y. gender, socio demographics, economic, finance, health care, costs, physical disability, dementia
Ward SA, Storey E, Gasevic D, Naughton MT, Hamilton GS, Trevaks RE, Wolfe R, O'Donoghue F, Stocks N, Abhayaratna WP, Fitzgerald S, Orchard SG, Ryan J, McNeil JJ, Reid CM, Woods RL. Sleep-disordered breathing was associated with lower health-related quality of life and cognitive function in a cross-sectional study of older adults. Respirology. 2022; May 17, doi: 10.1111/resp.14279. sleep disordered breathing, SDB, apnoea, apnea, quality of life, QoL, HRQoL, physical, cognition, cognitive, neurological, snore, SNORE-ASA, sub-study, substudy
Lacaze P, Wang Y, Polekhina G, Bakshi A, Riaz M, Owen A, Franks A, Abidi J, Tiller J, McNeil J, Cicuttini F. Genomic risk score for advanced osteoarthritis in older adults. Arthritis Rheumatol. 2022; May 4, doi: 10.1002/art.42156 [online ahead of print]. osteoarthritis, OA, genomics, genomes, DNA, variants, PV, PRS, polygenic, risk prediction, carriers, genetic testing, biobank, sub-study, substudy
Agustini B, Lotfaliany M, Mohebbi M, Woods RL, McNeil JJ, Nelson MR, Shah R, Murray A, Reid CM, Tonkin A, Ryan J, Williams LJ, Forbes MP, Berk M. Trajectories of depressive symptoms in older adults and associated health outcomes. Nat Aging. 2022; Apr 19, doi: 10.1038/s43587-022-00203-1. depression, CES-D, CES-D-10, CESD, depressive, cognitive, mental, mood, dementia, cancer, haemorrhage, hemorrhage, physical disability, disability-free, progression, trajectories, risk
Neumann JT, Thao LTP, Murray AM, Callander E, Carr PR, Nelson MR, Wolfe R, Woods RL, Reid CM, Shah RC, Newman AB, Williamson JD, Tonkin AM, McNeil JJ. Prediction of disability-free survival in healthy older people. GeroScience. 2022; Apr 14, doi: 10.1007/s11357-022-00547-x. risk, disability, free, survival, cognition, cognitive, dementia, physical disability, death, mortality
Polkinghorne KR, Wetmore JB, Thao LTP, Wolfe R, Woods RL, Ernst ME, Nelson MR, Reid CM, Shah RC, McNeil JJ, Murray AM. Effect of Aspirin on CKD Progression in Older Adults: Secondary Analysis From the ASPREE Randomized Clinical Trial. American Journal of Kidney Diseases. 2022; Apr 14, doi: 10.1053/j.ajkd.2022.02.019 [pre-proof]. eGRF, CKD, chronic kidney disease, CKD, proteinuria, albuminuria, UACR, urine ratio
Jadhao S, Davison C, Roulis EV, Lee S, Lacaze P, Riaz M, McNeil JJ, Thomas DM, Pecheniuk NM, Hyland CA, Flower R, Nagaraj SH. Using Whole Genome Sequencing to Characterize Clinically Significant Blood Groups Among Healthy Older Australians. Blood Adv. 2022; Apr 14, doi: 10.1182/bloodadvances.2022007505. blood group, type, MGRB, reference bank, genetics, genomic, genome, carriers, genotyping, variant, DNA, genetic testing, sub-study, substudy
Craig H, Ryan J, Freak-Poli R, Owen A, McNeil J, Woods RL, Britt C, Tonkin A, Gasevic D. The Association of Dispositional Optimism and Pessimism With Cardiovascular Disease Events in Older Adults: A Prospective Cohort Study. J Aging Health. 2022, doi: 10.1177/08982643221083118 [online ahead of print 2022; Apr 11]. dispositional optimism, pessimism, psychosocial, LOT-R, Life Orientation Test—Revised, ALSOP, sub-study, substudy, longitudinal, questionnaires, CVD, cardiovascular disease, cardiac
Yan MK, Orchard SG, Adler NR, Wolfe R, McLean C, Rodriguez LM, Woods RL, Gibbs P, Chan AT, Haydon A, Mar VJ. Effect of Aspirin on Melanoma Incidence in Older Persons: Extended Follow-up of a Large Randomized Double-blind Placebo-controlled Trial. Cancer Prev Res (Phila). 2022; Apr 8, doi: 10.1007/s11357-022-00547-x. skin cancer, melanoma, chemoprotection, chemoprotective, aspirin
Zhou Z, Nelson M, Ernst ME, Reid C, McNeil J, Tonkin A, on behalf of the ASPREE Investigator Group. Does aspirin prevent incident heart failure in healthy older adults? Examining the evidence from the ASPREE trial. Circulation: Heart Failure 2022; Apr 5, doi: 510.1161/CIRCHEARTFAILURE.122.009511. Heart failure, HF, CVD, cardiovascular disease, aspirin, coronary
Wrigglesworth J, Harding I, Ward P, Woods RL, Storey E, Fitzgibbon B, Egan G, Murray A, Shah R, Trevaks R, Ward S, McNeil JJ, Ryan J. Factors Influencing Change in Brain-Predicted Age Difference in a Cohort of Healthy Older Individuals. Journal of Alzheimer's Disease Reports. 2022; April 4, doi:10.3233/ADR-220011. biomarkers, cognition, depression, health status, neuroimaging, physical fitness, quality of life, QoL
Bakshi A, Cao Y, Orchard SG, Carr PR, Joshi AD, Manning AK, Buchanan DD, Umar A, Winship IM, Gibbs P, Zalcberg JR, Macrae F, McNeil JJ, Lacaze P, Chan A. Aspirin and the risk of colorectal cancer according to genetic susceptibility among older individuals. Cancer Prev Res (Phila). 2022; Mar 29, doi: 10.1158/1940-6207.CAPR-22-0011 [epub ahead of print]. cancer, colorectal, CRC, PRS, genetics, genomic, genome, carriers, polygenic, risk prediction, PRS, genotyping, variant, DNA, genetic testing, biobank, sub-study, substudy
Phyo AZZ, Gonzalez-Chica DA, Stocks NP, Woods RL, Tran T, Reid CM, Tonkin AT, Nelson MR, McNeil JJ, Murray AM, Gasevic D, Freak-Poli R, Ryan J. Trajectories of physical health-related quality of life and the risk of incident cardiovascular disease events and all-cause mortality in older people. American Heart Journal Plus: Cardiology Research and Practice. 2022, doi: 10.1016/j.ahjo.2022.100117 [published online 2022; Mar 23]. trajectory, physical, quality of life, QOL, HRQoL, CVD, PCS, cardiac, cardiovascular disease, mortality
Ekram ARMS, Woods RL, Ryan J, Espinoza SE, Gilmartin-Thomas JFM, Shah RC, Mehta R, Kochar B, Lowthian JA, Lockery J, Orchard S, Nelson M, Fravel MA, Liew D, Ernst ME. The association between polypharmacy, frailty and disability-free survival in community-dwelling healthy older individuals. Archives of Gerontology and Geriatrics. 2022; Mar 23, doi: 10.1016/j.archger.2022.104694 [epub ahead of print]. disability free survival, DFS, frailty, index, Fried polypharmacy, medications, prescription, outcomes, physical function, cognition
Nelson MR, Polekhina G, Woods RL, Reid CR, Tonkin AM, Wolfe R, Murray AM, Kirpach B, Ernst ME, Lockery JE, Shah RC, Stocks N, Orchard SG, Zhou Z. Safety of Ceasing Aspirin Used Without a Clinical Indication After Age 70 Years: A Subgroup Analysis of the ASPREE Randomized Trial. Ann Intern Med. 2022; Mar 15, doi: 10.7326/M21-3823 [epub ahead of print]. Accompanying EDITORIAL 2022; Mar 15, doi: 10.7326/M22-0550 aspirin cessation, CVD, cardiac, disability-free survival, mortality, haemorrhage, hemorrhage, bleeding, cancer, endpoints
Muhandiramge J, Orchard SG, Warner ET, van Londen GJ, Zalcberg JR. Functional Decline in the Cancer Patient: A Review. Cancers. 2022; Mar 8, doi: 10.3390/cancers14061368 cancer, functional decline, functional status, frailty, review
Govindaraju T, McCaffrey TA, McNeil JJ, Reid CM, Smith BJ, Campbell DJ, Liew D, Owen AJ. Quality of life and associations with health-related behaviours among older adults with increased cardiovascular risk. Nutrition, Metabolism and Cardiovascular Diseases. 2022; Jan 29, doi: 10.1016/j.numecd.2022.01.025 [epub ahead of print]. physical, activity, smoking, alcohol consumption, health-related behaviour, disease, quality of life, QOL, diet
Neumann JT, Thao LTP, Callander E, Carr PR, Qaderi V, Nelson MR, Reid CR, Woods RJ. Orchard SG, Wolfe R, Polekhina G, Williamson JMR, Trauer JM, Newman AB, Murray AM, Ernst ME, Tonkin AM, McNeil JJ. A multistate model of health transitions in older people: a secondary analysis of ASPREE clinical trial data. Lancet Healthy Longev. 2022; Feb 1, doi:10.1016/S2666-7568(21)00308-1 Accompanying EDITORIAL 2022; Feb doi.org/10.1016/S2666-7568(22)00011-3 transition, mortality, health, illness, cancer, stroke, cardiac, CVD, cardiovascular disease, disability, dementia
Islam RM, Bell RJ, Handelsman DJ, McNeil JJ, Nelson MR, Reid CM, Tonkin AM, Wolfe RS, Woods RL, Davis SR. Associations between blood sex steroid concentrations and risk of major adverse cardiovascular events in healthy older women in Australia: a prospective cohort substudy of the ASPREE trial. Lancet Healthy Longev. 2022; Feb 1, doi:10.1016/S2666-7568(21)00308-1. Accompanying EDITORIAL 2022; Feb 3, doi.org/10.1016/S2666-7568(22)00008-3 CVD, cardiovascular, cardiac, risk factors, sub-study, substudy, SHOW, women, females, estrone, oestrone, estradiol, oestradiol, testosterone, androgen, sex hormones, blood, serum, oestrogen, postmenopause, sub-study, substudy, biobank, steroids
Neumann JT, Riaz M, Bakshi A, Polekhina G, Thao LTP, Nelson MR, Woods RL, Abraham G, Inouye M, Reid CM, Tonkin AM, McNeil J, Lacaze P. Prognostic Value of a Polygenic Risk Score for Coronary Heart Disease in Individuals Aged 70 Years and Older. Circ Genom Precis Med. 2021; Dec 24, doi.org/10.1186/s12877-021-02602-2 [epub ahead of print]. genetics, genomic, genome, carriers, polygenic, PRS, genotyping, variant, DNA, genetic testing, risk, CVD, cardiovascular disease, CHD, coronary heart disease
Freak-Poli R, Ryan J, Neumann JT, Tonkin A, Reid CM, Woods RL, Nelson M, Stocks N, Berk M, McNeil J, Britt C, Owen A. Social isolation, social support and loneliness as predictors of cardiovascular disease incidence and mortality. BMC Geriatr. 2021; Dec 13, doi.org/10.1186/s12877-021-02602-2. CVD, cardiovascular, cardiac, risk factors, social, health, isolation, support, loneliness, CES-D, CES-D-10, CESD, ALSOP, sub-study, substudy
Riaz M, Mattisson J, Polekhina G, Bakshi A, Halvardson J, Danielsson M, Ameur A, McNeil, J, Forsberg LA, Lacaze P. A polygenic risk score predicts mosaic loss of chromosome Y in circulating blood cells. Cell Biosci. 2021; Dec 12, doi.org/10.1186/s13578-021-00716-z. genomics, genomes, DNA, pathogenic, genes, variants, PV, carriers, genetic testing, Mosaic loss, chromosome Y, LOY mLOY, PRS, risk, polygenic, biobank, sub-study, substudy
Southey MC, Dowty JG, Riaz M, Steen JA, Renault AL, Tucker K, Kirk J, James P, Winship I, Pachter N, Poplawski N, Grist S, Park DJ, Pope BJ, Mahmood K, Hammet F, Mahmoodi M, Tsimiklis H, Theys D, Rewse A, Willis A, Morrow A, Speechly C, Harris R, Sebra R, Schadt E, Lacaze P, McNeil JJ, Giles GG, Milne RL, Hopper JL, Nguyen-Dumont T. Population-based estimates of breast cancer risk for carriers of pathogenic variants identified by gene-panel testing. NPJ Breast Cancer. 2021; Dec 9, doi: 10.1038/s41523-021-00360-3. genomics, genomes, DNA, pathogenic, genes, variants, PV, carriers, genetic testing, breast cancer, screening, BRCA1, BRCA2, CHEK2, risk, biobank, sub-study, substudy, control
Murray AM, Thao LTP, Ryan J, Wolfe R, Wetmore JB, Woods RL, Polkinghorne KR. Chronic kidney disease biomarkers, cognitive impairment and incident dementia in an older healthy cohort. Kidney360. 2021; Dec 7, doi.org/10.34067/KID.0005672021 [epub ahead of print]. cognitive decline, cognition, dementia, chronic kidney disease, CKD, proteinuria, albuminuria
Broder, JC, Ryan, J, Shah, RC, Lockery JE, Orchard SG, Gilmartin-Thomas JFM, Fravel MA, Owen AJ, Woods RL, Wolfe R, Storey E, Murray AM, Ernst ME. Anticholinergic medication burden and cognitive function in participants of the ASPREE study. Pharmacotherapy. 2021; Dec 6, doi:10.1002/phar.2652. anticholinergic, medications, prescriptions, pharmacy, dementia, cognitive decline, cognition, 3MS, 3ms, COWAT, HVLT-R, SDMT
Selvadurai MV, Riaz M, Xie S, Tonkin A, McNeil JJ, Lacaze P, Hamilton J. The PAR4 platelet thrombin receptor variant rs773902 does not impact the incidence of thrombotic or bleeding events in a healthy older population. Thromb Haemost. 2021; Dec 1, doi: 10.1055/a-1711-1395 [epub ahead of print]. PMID: 34852379 genetics, genomic, genome, carriers, risk, genotyping, variant, DNA, genetic testing, PAR4, bleeding, thrombotic, haemorrhage, hemorrhage, CVD, cardiovascular, stroke, MACE, biobank, sub-study, substudy
Bakshi A, Riaz M, Orchard SG, Carr PR, Joshi AD, Cao Y, Rebello R, Nguyen-Dumont T, Southey MC, Millar JL, Gately L, Gibbs P, Ford LG, Parnes HL, Chan AT, McNeil JJ, Lacaze P. A Polygenic Risk Score Predicts Incident Prostate Cancer Risk in Older Men but Does Not Select for Clinically Significant Disease. Cancers. 2021; Nov 19, doi: 10.3390/cancers13225815. genetics, genomic, genome, carriers, polygenic, risk prediction, PRS, genotyping, variant, DNA, genetic testing, prostate cancer, biobank, sub-study, substudy
Neumann JT, Thao LTP, Callander E, Chowdhury E, Williamson JD, Nelson MR, Donnan G, Woods RL, Reid CR, Poppe KK, Jackson R, Tonkin AM, McNeil JJ. Cardiovascular risk prediction in healthy older people. GeroScience. 2021; Nov 11, doi: 10.1007/s11357-021-00486-z. CVD, cardiovascular, stroke, CVA, MACE, coronary, cardiac, heart failure, cerebral, diseases, endpoint, risk prediction, risk factors, risk score
Espinoza SE, Woods RL, Ekram ARMS, Ernst ME, Polekhina G, Wolfe R, Shah RC, Ward SA, Storey E, Nelson MR, Reid CM, Lockery JE, Orchard SG, Trevaks R, Fitzgerald SM, Stocks NP, Chan A, McNeil JJ, Murray AM, Newman AB, Ryan J; ASPREE Investigator Group. The effect of low-dose aspirin on frailty phenotype and frailty index in community-dwelling older adults in the ASPirin in Reducing Events in the Elderly study. J Gerontol A Biol Sci Med Sci. 2021; Nov 10, doi: 10.1093/gerona/glab340. [epub ahead of print]. PMID: 34758073 Fried frailty, phenotype, incident, dementia, biological markers, physical, disability, walking speed, grip, frailty, index, health, outcomes, survival, lifespan, risk
Joyce J, Ryan J, Owen A, Hu J, McHugh Power J, Shah RC, Woods RL, Storey E, Britt C, Freak-Poli R, ASPREE Investigator Group. Social isolation, social support, and loneliness and their relationship with cognitive health and dementia. Int J Geriatr Psychiatry. 2021; Nov 5, doi: 10.1002/gps.5644. social, health, isolation, support, loneliness, ALSOP, sub-study, substudy, dementia, cognitive, cognition, neurological, cognitive decline, Alzheimers disease, Alzheimer's, 3MS, 3ms, memory, COWAT, HVLT-R, SDMT
Neumann JT, Freak-Poli R, Orchard SG, Wolfe R, Reid CM, Tonkin AM, Beilin LJ, McNeil JJ, Ryan J, Woods RL. Alcohol consumption and risks of cardiovascular disease and all-cause mortality in healthy older adults. European Journal of Preventive Cardiology. 2021; Oct 28, doi: 10.1093/eurjpc/zwab177. alcohol, deaths, mortality, CVD, cardiovascular, coronary, cardiac, heart failure, HF, stroke, cerebral, diseases, risks
Phyo AZZ, Gonzalez-Chica DA, Stocks N,  Woods RLW, Fisher J, Tran T, Owen A, Ward S, Britt C, Ryan J, Freak-Poli R. Impact of economic factors, social health and stressful life events on physical health-related quality of life trajectories in older Australians. Qual Life Res. 2021; Oct 22, doi: 10.1007/s11136-021-03021-x. HRQoL, QOL, quality of life, physical, social health, trajectories, lifespan, SF-12, mood, economic, life stressors, socio-economic, determinants
Wrigglesworth J, Yaacob N, Ward P, Woods RL, McNeil JJ, Storey E, Egan G, Murray A, Shah RC, Jamadar SD, Trevaks T, Ward W, Harding IH, Ryan J. Brain-predicted age difference is associated with cognitive processing in later-life. Neurobiology of Aging. 2021; Oct 20, doi: 10.1016/j.neurobiolaging.2021.10.007 [epub ahead of print]. MRI, neuroimaging, NEURO, sub-study, substudy, cognitive function, cognition, neurological, brain age, 3MS, 3ms, memory, COWAT, HVLT-R, SDMT
Craig HJ, Ryan J, Freak-Poli R, Owen A, McNeil J, Woods R, Ward S, Britt C, Gasevic D. Dispositional Optimism and All-Cause Mortality in Older Adults: A Cohort Study. Psychosom Med. 2021; Oct 1, doi: 10.1097/PSY.0000000000000989. PMID: 34334727 psychosocial, dispositional optimism, mortality, LOT-R, Life Orientation Test—Revised, mortality, death, survival, lifespan, ALSOP, longitudinal, questionnaires, sub-study, substudy
Lin X, Banaszak-Holl J, Xie J, Ward SA, Brodaty H, Storey E, Shah RC, Murray A, Ryan J, Orchard SG, Fitzgerald SM, McNeil JJ. Similar mortality risk in incident cognitive impairment and dementia: Evidence from the ASPirin in Reducing Events in the Elderly (ASPREE) trial. J Am Geriatrics Soc. 2021; Sept 17, doi: 10.1111/jgs.17435. mortality, death, endpoints, end-points, outcomes, risks, dementia, cognitive decline, impairment, cognition, Alzheimers disease, Alzheimer's, 3MS, 3ms, memory, COWAT, HVLT-R, SDMT
Ernst ME, Fravel MA, Webb KL, Wetmore JB, Wolfe R, Chowdhury E, Reid CM, Woods RL, Beilin L, Margolis KL, Murray AM, Polkinghorne KR; ASPirin in Reducing Events in the Elderly Investigator Group. Long-term Blood Pressure Variability and Kidney Function in Participants of the ASPREE Trial. Am J Hypertens. 2021; Sep 14, doi: 10.1093/ajh/hpab143 [epub ahead of print]. Accompanying EDITORIAL 2021; Oct 8, doi: doi.org/10.1093/ajh/hpab160. chronic kidney disease, CKD, blood pressure, hypertension, CVD, cardiac, cardiovascular, BPV, blood pressure variability
Fransquet PD, Lacaze P, Saffery R, Shah RC, Vryer R, Murray A, Woods RL, Ryan J. Accelerated Epigenetic Aging in Peripheral Blood Does not Predict Dementia Risk. Curr Alzheimer Res. 2021; Aug 22, doi: 10.2174/1567205018666210823100721 [epub ahead of print]. PMID: 34429046 biomarkers, blood, DNA, DNAm, methylation, dementia, Alzheimers disease, Alzheimer's, cognition, cognitive, epigenetics, biobank, sub-study, substudy
Huq AJ, Fulton-Howard B, Riaz M, Laws S, Sebra R, Ryan J; Alzheimer's Disease Genetics Consortium, Renton AE, Goate AM, Masters CL, Storey E, Shah RC, Murray A, McNeil J, Winship I, James PA, Lacaze P. Polygenic score modifies risk for Alzheimer's disease in APOE ε4 homozygotes at phenotypic extremes. Alzheimers Dement (Amst). 2021; Aug 5, doi: 10.1002/dad2.12226, eCollection 2021. genetics, genomic, genome, carriers, polygenic, PRS, genotyping, variant, DNA, genetic testing, risk, APOE, E4, dementia, cognitive, cognition, neurological, Alzheimers, cognitive decline, 3MS, 3ms, COWAT, HVLT-R, SDMT, biobank, sub-study, substudy
Ryan J, Espinoza S,  Ernst ME, Saifuddin Ekram ARM, Wolfe R, Murray AM, Shah RC, Orchard SG, Fitzgerald S, Beilin LJ, Ward SA, Williamson JD, Newman AB, McNeil JJ, Woods RL, on behalf of the ASPREE Investigator Group. Validation of a deficit-accumulation Frailty Index in the ASPREE study and its predictive capacity for disability-free survival. Journals of Gerontology: Series A. 2021; Aug 02, doi.org/10.1093/gerona/glab225. Fried, phenotype, dementia, biological markers, physical, disability, walking speed, grip, frailty, index, health, outcomes, survival, lifespan, risk, mortality, death
Lacaze P, Riaz M, Sebra R, Hooper AJ, Pang J, Tiller J, Polekhina G, Tonkin A, Reid C, Zoungas S, Murray AM, Nicholls S, Watts G, Schadt E, McNeil JJ. Protective lipid-lowering genetic variants in healthy older individuals without coronary heart disease. Open Heart. 2021; Aug 02, doi: 10.1136/openhrt-2021-001710. genomics, genomes, DNA, pathogenic, genes, DNA, variants, PV, carriers, genetic testing, PCSK9 and APOB, cholesterol, lipids, LDL-C, TC, biobank, sub-study, substudy
Lacaze P, Bakshi A, Riaz M, Orchard SG, Tiller J, Neumann JT, Carr PR, Joshi AD, Cao Y, Warner ET, Manning A, Nguyen-Dumont T, Southey MC, Milne RL, Ford L, Sebra R, Schadt E, Gately L, Gibbs P, Thompson BA, Macrae FA, James P, Winship I, McLean C, Zalcberg JR, Woods RL, Chan AT, Murray AM, McNeil JJ. Genomic Risk Prediction for Breast Cancer in Older Women. Cancers. 2021; July 14, doi.org/10.3390/cancers13143533. genetics, genomic, genome, carriers, polygenic, risk prediction, PRS, genotyping, variant, DNA, genetic testing, breast cancer, biobank, sub-study, substudy
Hu J, Fitzgerald SM, Owen AJ, Ryan J, Joyce J, Chowdhury E, Reid CM, Britt C, Woods RL, McNeil JJ, Freak-Poli R. Social isolation, social support, loneliness and cardiovascular disease risk factors: a cross-sectional study among older adults. Int J Geriatr Psychiatry. 2021; July 7, doi: /10.1002/gps.5601. CVD, cardiovascular, cardiac, risk factors, Framingham Risk Scale, ASCVDRS, social, health, isolation, support, loneliness, CES-D, CES-D-10, CESD, depressive symptoms, ALSOP, sub-study, substudy
Phyo AZZ, Ryan J, Gonzalez-Chica DA, Stocks NP, Reid CM, Tonkin AM, Woods RL, Nelson MR, Murray AM, Gasevic D, Freak-Poli R. Health-related quality of life and incident cardiovascular disease events in community-dwelling older people: A prospective cohort study. International Journal of Cardiology. 2021, doi: /10.1016/j.ijcard.2021.07.004 [published online 2021; July 7]. quality, health, physical, QOL, SF-12, HRQol, CVD, cardiac, cardiovascular
Chowdhury EK, Ernst ME, Nelson M, Margolis K, Beilin LJ, Johnston C, Woods R, Murray A, Wolfe R, Storey E, Shah RC, Lockery J, Tonkin A, Newman A, Abhayaratna W, Stocks N, Fitzgerald S, Orchard S, Trevaks R, Donnan G, Grimm R, McNeil J, Reid CM; ASPREE Investigator Group. Impact of the 2017 American Heart Association and American College of Cardiology hypertension guideline in aged individuals. J Hypertens. 2020; Dec,doi: 10.1097/HJH.0000000000002582. PMID: 32740404; PMCID: PMC8218338 blood pressure, hypertension, CVD, cardiac, cardiovascular, medications, guidelines
Lacaze P, Sebra R, Riaz M, Ingles J, Tiller J, Thompson BA, James PA, Fatkin D, Semsarian C, Reid CM, Tonkin AM, Winship I, Schadt E, McNeil JJ. Genetic variants associated with inherited cardiovascular disorders among 13,131 asymptomatic older adults of European descent. NPJ Genom Med. 2021; Jun 16, doi: 10.1038/s41525-021-00211-x. PMID: 34135346; PMCID: PMC8209162 genetics, genomic, genome, carriers, inherited, familial, genotyping, variant, DNA, genetic testing, risk, CVD, cardiac, cardiovascular, long-QT syndrome, SCD, biobank, sub-study, substudy
Zhou Z, Ryan J, Ernst ME, Zoungas S, Tonkin AM, Woods RL, McNeil JJ, Reid CM, Curtis AJ, Wolfe R, Wrigglesworth J, Shah RC, Storey E, Murray A, Orchard SG, Nelson MR. Effect of statin therapy on cognitive decline and incident dementia in older adults. J Am Coll Cardiol. 2021; June 29, doi:10.1016/j.jacc.2021.04.075. statins, medications, prescriptions, pharmacy, dementia, cognitive, cognition, neurological, cognitive decline, Alzheimers disease, Alzheimer's, 3MS, 3ms, memory
Ernst ME, Ryan J, Chowdhury EK, Margolis KL, Beilin LJ, Reid CM, Nelson MR, Woods RL, Shah RC, Orchard SG, Wolfe R, Storey E, Tonkin AM, Brodtmann A, McNeil JJ, Murray AM. Long-Term Blood Pressure Variability and Risk of Cognitive Decline and Dementia Among Older Adults. J Am Heart Assoc. 2021; June 26, doi:10.1161/JAHA.120.019613. blood pressure, hypertension, CVD, cardiac, cardiovascular, medications, BPV, blood pressure variability, dementia, cognitive, cognition, neurological, cognitive decline, Alzheimers disease, Alzheimer's, 3MS, 3ms, memory, COWAT, HVLT-R, SDMT
Neumann JT, Riaz M, Bakshi A, Polekhina G, Thao LTP, Nelson MR, Woods RL, Abraham G, Inouye M, Reid CM, Tonkin AM, Williamson JD, Donnan G, Brodtmann A, Cloud GC, McNeil JJ, Lacaze P. Predictive performance of a polygenic risk score for incident ischemic stroke in a healthy older population. Stroke. 2021, doi: 10.1161/STROKEAHA.120.033670. [epub ahead of print 2021; May 27]. genetics, genomic, genome, carriers, polygenic, PRS, genotyping, variant, DNA, genetic testing, risk, ischaemic, ischemic, stroke, CVA, cardiovascular, CVD, cardioembolic
Riaz M, Huq A, Ryan J, Orchard SG, Tiller J, Lockery J, Woods RL, Wolfe R, Renton AE, Goate AM, Sebra R, Schadt E, Brodtmann A, Shah RC, Storey E, Murray AM, McNeil JJ, Lacaze P. Effect of APOE and a polygenic risk score on incident dementia and cognitive decline in a healthy older population. Aging Cell. 2021, doi: 10.1111/acel.13384. [epub ahead of print 2021; May 26]. PMID: 34041846 genetics, genomic, genome, carriers, polygenic, PRS, genotyping, variant, DNA, genetic testing, risk, APOE, dementia, cognitive, cognition, neurological, Alzheimers, cognitive decline, 3MS, 3ms, COWAT, HVLT-R, SDMT
Nunn JS, Sulovski M, Tiller J, Holloway B, Ayton D, Lacaze P. Involving elderly research participants in the co-design of a future multi-generational cohort study. Research Involvement and Engagement. 2021; May 3, doi: org/10.1002/dad2.12180. participatory research, multigenerational, design, co-design, participants, consumers, familial, inherited
Wu Z, Woods RL, Wolfe R, Storey E, Chong TTJ, Shah RC, Orchard SG, McNeil JJ, Murray AM, Ryan J; the ASPREE Investigator Group. Trajectories of cognitive function in community‐dwelling older adults: A longitudinal study of population heterogeneity. Alzheimer’s Dement. 2021; May 2, doi: org/10.1002/dad2.12180. dementia, Alzheimers disease, Alzheimer's, cognition, cognitive, 3MS, 3ms, neurological, trajectory, memory, function, COWAT, HVLT‐R, SDMT, modelling
Bakshi A, Yan M, Riaz M, Polekhina G, Orchard SG, Tiller J, Wolfe R, Joshi A, Cao Y, McInerney-Leo AM, Yanes T, Janda M, Soyer HP, Cust AE, Law MH, Gibbs P, McLean C, Chan AT, McNeil JJ, Mar VJ, Lacaze P. Genomic Risk Score for Melanoma in a Prospective Study of Older Individuals. J Natl Cancer Inst. 2021, doi: 10.1093/jnci/djab076 [epub ahead of print 2021; April 10]. PMID: 33837773 genetics, genomic, genome, carriers, polygenic, PRS, genotyping, variant, DNA, genetic testing, risk, melanoma, cancer, skin, biobank, sub-study, substudy
Nguyen-Dumont T, Dowty JG, MacInnis RJ, Steen JA, Riaz M, Dugue PA, Renault AL, Hammet F, Mahmoodi M, Theys D, Tsimiklis H, Severi G, Bolton D, Lacaze P, Sevra R, Schadt E, McNeil J, Giles GG, Milne RL, Southey MC. Rare germline pathogenic variants identified by multigene panel testing and the risk of aggressive prostate cancer. Cancers. 2021; March 24, doi: 10.3390/cancers13071495. genetics, genomic, genome, carriers, polygenic, pathogenic, PV, carrier, genotyping, variant, DNA, genes, genetic testing, prostate cancer, biobank, sub-study, substudy
Lockery JE, Broder JC, Ryan J, Stewart AC, Woods RL, Chong TT, Cloud GC, Murray A, Rigby JD, Shah R, Storey E, Ward SA, Wolfe R, Reid CM, Collyer TA, Ernst ME; the ASPREE Investigator Group. A Cohort Study of Anticholinergic Medication Burden and Incident Dementia and Stroke in Older Adults. J Gen Intern Med. 2021, doi: 10.1007/s11606-020-06550-2 [published online 2021; March 22]. PMID: 33754317 anticholinergic, medications, prescriptions, pharmacy, stroke, CVA, dementia, cognitive decline, cognition, 3MS, 3ms
Phyo AZZ, Gonzalez-Chica DA, Stocks NP, Storey E, Woods RL, Murray AM, Orchard SG, Shah RC, Gasevic D, Freak-Poli R, Ryan J; ASPREE Investigator Group. The Utility of Assessing Health-Related Quality of Life to Predict Cognitive Decline and Dementia. J Alzheimers Dis. 2021, doi: 10.3233/JAD-201349 [published online 2021; Feb 12]. PMID: 33579847 lifestyle, QOL, HRQoL, quality, health, mental, SF-12, mood, dementia, cognitive decline, cognition, 3MS
EDITORIAL McNeil JJ. Aspirin and primary prevention of colorectal cancer: a still evolving story. JNCI: Journal of the National Cancer Institute. 2021, doi:org/10.1093/jnci/djab010 [published online 2021; Feb 02]. aspirin, cancers, mortality, deaths, neoplasms, diagnosis, endpoints, end-points, end points, chemoprotective, incidence, CRC, metastasis, non-metastatic, metastatic 
Berk M, Agustini B, Woods RL, Nelson MR, Shah RC, Reid CM, Storey E, Fitzgerald S, Lockery JE, Wolfe R, Mohebbi M, Dodd S, Murray AM, Stocks N, Fitzgerald P, Mazza C, McNeil JJ. Effects of aspirin on the long-term management of depression in older people: a double-blind randomised placebo-controlled trial. Mol Psychiatry. 2021, doi: org/10.1038/s41380-021-01020-5 [published online 2021; Jan 27]. aspirin, depression, CES-D, CES-D-10, CESD, depressive, cognitive, mood, mental, endpoints, end-points, end points, sub-study, substudy, prevention, psychiatry
Phyo A, Ryan J, Gonzalez-Chica DA, Woods RL, Reid CM, Nelson MR, Murray AM, Gasevic D, Stocks NP, Freak-Poli R; the ASPREE Investigator Group. Health-related quality of life and all-cause mortality among older health individuals in Australia and the United States: a prospective cohort study. Quality of Life Research. 2021, doi:10.1007/s11136-020-02723-y [published online 2021; Jan 03]. lifestyle, QOL, HRQoL, quality, health, mental, physical, SF-12, mood, mortality
Woods RL, Espinoza S, Thao LTP, Ernst ME, Ryan J, Wolfe R, Shah RC, Ward SA, Storey E, Nelson MR, Reid CM, Lockery JE, Orchard SG, Trevaks RE, Fitzgerald SM, Stocks NP, Williamson JD, McNeil JJ, Murray AM, Newman AB; ASPREE Investigator Group. Effect of Aspirin on Activities of Daily Living Disability in Community-Dwelling Older Adults. J Gerontol A Biol Sci Med Sci. 2020, doi:10.1093/gerona/glaa316 [published online ahead of print 2020; Dec 26]. aspirin, physical function, ADLS, disability, prevention, functional, activities daily living
Islam RM, Bell RJ, Handelsman DJ, Robinson PJ, Wolfe R, Davis SR; ASPREE Investigator Group. Longitudinal changes over three years in sex steroid hormone levels in women aged 70 years and over. Clin Endocrinol (Oxf). 2020; Dec 22, doi: 10.1111/cen.14401 [epub ahead of print]. PMID: 33351205 sub-study, substudy, SHOW, women, females, estrone, oestrone, estradiol, oestradiol, testosterone, androgen, sex hormones, blood, serum, oestrogen, postmenopause, sub-study, substudy, biobank, steroids
Lefevre A, Hopper I, McNeil JJ, Owen A; ALSOP Complementary Medicine Research Group. Complementary medicine use by community-dwelling older Australians. Med J Aust. 2020, doi:10.5694/mja2.50884 [published online ahead of print 2020; Dec 9]. ALSOP, sub-study, substudy, longitudinal, questionnaires, complementary medicine, vitamins, supplements
Gilmartin-Thomas JF, Forbes A, Liew D, McNeil JJ, Cicuttini FM, Owen AJ, Ernst ME, Nelson MR, Lockery J, Ward SA, Busija L; ASPREE Investigator Group. Evaluation of the Pain Impact Index for community-dwelling older adults through the application of Rasch modelling. Pain Pract. 2020; Dec 9, doi: 10.1111/papr.12980 [epub ahead of print]. PMID: 33295122 pain, knee, back, ALSOP, substudy, sub-study, questionnaires, Rasch analysis, psychometrics
Ernst ME, Chowdhury EK, Beilin LJ, Margolis KL, Nelson MR, Wolfe R, Tonkin AM, Ryan J, Woods RL, McNeil JJ, Reid CR, for the ASPREE Investigator Group. Long-Term Blood Pressure Variability and Risk of Cardiovascular Disease Events Among Community-Dwelling Elderly. Hypertension. 2020, doi:10.1161/HYPERTENSIONAHA.120.16209 [published online 2020; Nov 2]. blood pressure, hypertension, CVD, cardiac, cardiovascular, BPV, blood pressure variability, medications, poly pharmacy, prescriptions
Lockery JE, Ernst ME, Broder JC, Orchard SG, Murray A, Nelson MR, Stocks NP, Wolfe R, Reid CM, Liew D, Woods RL; ASPREE Investigator Group. Prescription Medication Use in Older Adults Without Major Cardiovascular Disease Enrolled in the Aspirin in Reducing Events in the Elderly (ASPREE) Clinical Trial. Pharmacotherapy 2020; Oct 20, doi:10.1002/phar.2461. medications, poly pharmacy, prescriptions
Robman LD, Thao LTP, Guymer RH, Wolfe R, Woods RL, Hodgson LAB, Phung J, Makeyeva GA, Le-Pham YA, Orchard SG, Suleiman J, Maguire E, Trevaks RE, Ward SA, Riaz M, Lacaze P, Elsdon S, Abhayaratna WP, Nelson MR, Ernst ME, Reid CM, McNeil JJ; ASPREE Investigator Group. Baseline characteristics and age-related macular degeneration in participants of the "ASPirin in Reducing Events in the Elderly" (ASPREE)-AMD trial. Contemporary Clinical Trials Communications. 2020,  doi:10.1016/jconctc.2020.100667 [published online 2020; Oct 11]. aspirin, AMD, age related macular degeneration, age-related, substudy, sub-study, eye health, vision, retinal, haemorrhages, hemorrhages, wet, dry
Eisen DP, Leder K, Woods RL, Lockery JE, McGuinness SL, Wolfe R, Pilcher D, Moore EM, Shastry A, Nelson MR, Reid C, McNeil, JJ, McBryde ES. Effect of aspirin on deaths associated with sepsis in healthy older people (ANTISEPSIS): a randomised, double-blind, placebo-controlled primary prevention trial. The Lancet Respiratory Medicine. 2020,  doi.org/10.1016/S2213-2600(20)30411-2 [published online 2020; Sept 17]. aspirin, sepsis, death, mortality, hospitalisations, hospitalizations, substudy, sub-study
Gilmartin-Thomas JFM, Ernst ME, Nelson MR, Lockery JE, Ward SA, Woods RL, Britt C, Murray A, Workman B, McNeil JJ; ASPREE Investigator Group. Musculoskeletal Pain Experienced on Most Days is a Common Accompaniment of Ageing amongst Community-Dwelling Older Australians: A Questionnaire-Based Study. Journal of Aging and Health. 2020,  doi:10.1177/0898264320952914 [pre-print published online 2020; Sept 11]. pain, muscle, back, knee, analgesia, medications, pharmacy, ALSOP, substudy, sub-study, questionnaires
Wolfe R, Wetmore JB, Wood RL, McNeil JJ, Gallagher H, Roderick P, Walker R, Nelson MR, Reid CM, Shah RC, Ernst ME, Lockery JE, Tonkin AM, Abhayaratna WP, Gibbs P, Wood EM, Mahady SE, Williamson JD, Donnan GA, Cloud GC, Murray AM, Polkinghorne K, for the ASPREE Investigator Group. Subgroup analysis of the ASPirin in Reducing Events in the Elderly randomized clinical trial suggest aspirin did not improve outcomes in older adults with chronic kidney disease. Kidney International. 2020, doi.org/10.1016/j.kint.2020.08.011  [published online 2020; Sept 10]. aspirin, kidney, renal, GFR, CKD, urine, chronic kidney disease, aspirin, glomerular filtation rate
Gilmartin-Thomas JFM, Cicuttini FM, Owen AJ, Wolfe R, Ernst ME, Nelson MR, Lockery J, Woods RL, Britt C, Liew D, Murray A, Workman B, Ward SA, McNeil JJ; ASPREE Investigator Group. Moderate or severe low back pain is associated with body mass index amongst community-dwelling older Australians. Arch Gerontol & Geriatrics. 2020, doi:10.1016/j.archger.2020.104231[published online 2020; Aug 13]. pain, muscle, back, body mass, obesity, ALSOP, substudy, sub-study, questionnaires
McNeil JJ, Gibbs P, Orchard SG, Lockery JE, Bernstein WB, Cao Y, Ford L, Haydon A, Kirpach B, Macrae F, McLean C, Millar J, Murray AM, Nelson MR, Polekhina G, Reid CM, Richmond E, Rodríguez LM, Shah RC, Tie J, Umar A, van Londen GJ, Ronaldson K, Wolfe R, Woods RL, Zalcberg J, Chan A, for the ASPREE investigator Group. Effect of aspirin on cancer incidence and mortality in older adults. JNCI: Journal of the National Cancer Institute. 2020, doi.org/10.1093/jnci/djaa114 [accepted manuscript published online 2020; Aug 11]. aspirin, cancers, mortality, deaths, neoplasms, diagnosis, endpoints, end-points, end points, chemoprotective, incidence, CRC, metastasis, non-metastatic, metastatic
Ryan J, Woods RL, Britt CJ, Murray AM, Shah RC, Reid CM, Wolfe R, Nelson MR, Orchard SG, Lockery JE, Trevaks RE, Storey E, for the ASPREE Investigator Group. Normative Data for the Symbol Digit Modalities Test in Older White Australians and Americans, African-Americans, and Hispanic/Latinos. J Alzheimer’s Disease Reports. 2020, doi: 10.3233/ADR-200194 [published online 2020; Aug 04]. Alzheimer's disease, Alzheimers, cognition, dementia, SDMT, MMMs, MMMS, 3MS, 3ms, cognitive, characteristics, neurological
Mahady SE, Margolis KL, Chan A, Polekhina G, Woods RL, Wolfe R, Nelson MR, Lockery JE, Wood EM, Reid C, Ernst ME, Murray A, Thao LTP, McNeil JJ. Major GI bleeding in older persons using aspirin: incidence and risk factors in the ASPREE randomised controlled trial. Gut. 2020, doi:10.1136/gutjnl-2020-321585 [published online 2020; Aug 03]. aspirin, bleeding, bleed, haemorrhages, hemorrhages, GI, gastrointestinal, risks, factors
Orchard SG, Lockery JE, Gibbs P, Polekhina G, Wolfe R, Zalcberg J, Haydon A, McNeil JJ, Nelson MR, Reid CM, Kirpach B, Murray AM, Woods RL, for the ASPREE investigator Group. Cancer history and risk factors in healthy older people enrolling in the ASPREE clinical trial. Contemporary Clinical Trials. 2020,  doi.org/10.1016/j.cct.2020.106095 [published online 2020; July 31]. aspirin, bleeding, bleed, haemorrhages, hemorrhages, GI, gastrointestinal, risks, factors
Orchard ER, Ward PGD, Sforazzini F, Storey E, Egan G, Jamadar SD. Relationship between parenthood and cortical thickness in late adulthood. PLoS One. 2020, doi:10.1371/journal.pone.0236031 [published online 2020; July 28]. MRI, brain, neural changes, cortical, cognition, cognitive, parents, parenthood, parity, neurological
Ward PDG, Orchard ER, Oldham S, Arnatkevičiūtė A, Sforazzini F, Fornito A, Storey E, Egan G, Jamadar SD. Individual differences in haemoglobin concentration influence bold fMRI functional connectivity and its correlation with cognition. NeuroImage. 2020, doi:10.1016/j.neuroimage.2020.117196 [published online ahead of print 2020; July 25]. brain, haemoglobin, hemoglobin, cognitive, cognition, functional, connectivity, connectome, MRI, fMRI, neurological
Ernst ME, Chowdhury EK, Nelson MR, Reid CM, Margolis KL, Beilin LJ, Stocks N, Murray AM, Wolfe R, Lockery JE, Orchard SG, Woods RL, McNeil JJ; the ASPREE Investigator Group. Antihypertensive medications use and blood pressure control among treated older adults. J Clin Hypertens. 2020, doi.org/10.1111/jch.13934 [published online 2020; July 15]. anti-hypertensives, hypertension, blood pressure, medications, poly pharmacy, prescriptions
Fransquet PD, Lacaze P. Saffery R, Phung J, Parker E, Shah R, Murray A, Woods RL, Ryan J. Blood DNA methylation signatures to detect dementia prior to overt clinical symptoms. Alzheimer’s & Dementia. 2020, doi: 10.1002/dad2.12056 [published online 2020; July 7]. biomarkers, blood, DNA, DNAm, methylation, dementia, Alzheimers disease, Alzheimer's, cognition, cognitive, epigenetics, biobank, sub-study, substudy
Davis SR, Garcia AM, Robinson PJ, Handelsman DJ, Desai R, Wolfe R, Bell RJ, the ASPREE Investigator Group. Estrone is a strong predictor of circulating estradiol in women aged 70 years and older, The Journal of Clinical Endocrinology & Metabolism. 2020, doi.org/10.1210/clinem/dgaa429 [accepted manuscript 2020; July 02]. women, females, estrone, oestrone, estradiol, oestradiol, blood, blood, levels, androgen, oestrogen, postmenopause, sex hormones, substudy, sub-study, biobank, steroids
Lacaze P, Sebra R, Riaz M, Tiller J, Revote J, Phung J, Parker EJ, Orchard SG, Lockery JE, Wolfe R, Strahl M, Wang YC, Chen R, Sisco D, Arnold T, Thompson BA, Buchanan DD, Macrae FA, James PA, Abhayaratna WP, Lockett TJ, Gibbs P, Tonkin AM, Nelson MR, Reid CM, Woods RL, Murray AM, Winship I, McNeil JJ, Schadt E. Medically actionable pathogenic variants in a population of 13,131 healthy elderly individuals. Genet Med. 2020; doi: 10.1038/s41436-020-0881-7 [epub 2020; July 1]. PMID: 32606442; PMCID: PMC7606791 genomics, genome, DNA, pathogenic, genes, variants, PV, carriers, penetrance, Lynch syndrome, BRCA, BRCA1, BRCA2, LDLR, APOB, PCSK9, genetic testing, familial, biobank, substudy, sub-study
Zhou Z, Ofori-Asenso R, Curtis A, Breslin M, Wolfe R, McNeil JJ, Murray AM, Ernst ME, Reid CM, Lockery JE, Woods RL, Tonkin AM, Nelson MR. Association of Statin Use with Disability-Free Survival and Cardiovascular Disease among Healthy Older Adults. J Amer Coll Cardiol. 2020; June 30, doi:10.1016/j.jacc.2020.05.016. statins, CVD, medications, prescriptions, pharmacy, cardiovascular, heart, stroke, disability, disability-free, mortality, deaths, dementia
Lewis JP, Riaz M, Xie S, Polekhina G, Wolfe R, Nelson M, Tonkin AM, Reid CM, Murray AM, McNeil JJ, Shuldiner AR, Lacaze P. Genetic variation in PEAR1, cardiovascular outcomes and effects of aspirin in a healthy elderly population. Clin Pharmacol Ther. 2020, doi: 10.1002/cpt.1959 [online ahead of print 2020; June 20]. PMID: 32562573 aspirin, PEAR1, platelet, receptor, CVD, cardiovascular, haemorrhage, hemorrhage, genes, genetic testing, genomics, hypercholesterolemia, hypercholesterolaemia, biobank
Lacaze P, Sebra R, Riaz M, Hooper AJ, Tiller J, Bakshi A, Woods RL, Tonkin AM, Reid CM, Murray AM, Nicholls SJ, Watts GF, Schadt E, McNeil JJ. Familial Hypercholesterolemia in a Healthy Elderly Population. Circ Genom Precis Med. 2020; June 10, doi:10.1161/CIRCGEN.120.002938 [epub ahead of print]. genomics, genomes, DNA, pathogenic, genes, variants, PV, carriers, genetic testing, familial, CVD, cardiovascular, heart, stroke, cholesterol, hypercholesterolemia, hypercholesterolaemia, cholesterol, biobank, sub-study, substudy
Berk M, Woods RL, Nelson MR, Shah RC, Reid CM, Storey E, Fitzgerald S, Lockery JE, Wolfe, R, Mohebbi M, Dodd S, Murray AM, Stocks N, Fitzgerald P, Mazza C, Agustini B, McNeil JJ.  Effect of Aspirin vs Placebo on the Prevention of Depression in Older People: A Randomized Clinical Trial. JAMA Psychiatry. 2020, doi:10.1001/jamapsychiatry.2020.1214 [published online 2020; June 03].  aspirin, depression, CES-D, CES-D-10, CESD, depressive, cognitive, mood, mental, endpoints, end-points, end points, sub-study, substudy, prevention, psychiatry
Agustini B, Lotfaliany M, Woods RL, McNeil JJ, Nelson MR, Shah RC, Murray AM, Ernst M, Reid CM, Tonkin A, Storey E, Lockery JE, Williams LJ, Berk M, Mohebbi M, on behalf of the ASPREE investigators. Patterns of association between depressive symptoms and chronic medical morbidities in older adults. J Amer Geriatrics Soc. 2020, doi 10.1111/jgs.16468 [published online 2020; May 13].  depression, CES-D, CES-D-10, CESD , depressive, cognitive, mood, mental, co-morbidity, comorbidity, co-morbidities, comorbidities
Woods RL, Polekhina G, Wolfe R, Nelson MR, Ernst ME, Reid CM, Shah RC, Lockery JE, Orchard SG, Murray AM, McNeil JJ, on behalf of the ASPREE Investigator Group. No modulation of aspirin’s effect by body weight in healthy older men and women. Circulation. 2020; March 30,  doi.org/10.1161/CIRCULATIONAHA.119.044142. aspirin, BMI, weight, anthropometric, dose, dosage, CVD, cardiovascular, heart, stroke
Ryan J, Storey E, Murray AM, Woods RL, Wolfe R, Reid CM, Nelson MR, Chong T, Williamson JD, Ward SA, Lockery JE, Orchard SG, Trevaks R, Kirpach B, Newman AB, Ernst ME, McNeil JJ, Shah RC. Randomized Placebo-controlled Trial of the effects of Aspirin on Dementia and Cognitive Decline. Neurology. 2020; March 25, doi.org/10.1212/WNL.0000000000009277. aspirin, cognitive decline, cognition, dementia, Alzheimer's disease, Alzheimers, MCI, 3MS, MMMs, 3ms, MMMS, endpoints, end-points, end points
Barker AL, Soh SE, Sanders KM, Pasco J, Khosla S, Ebeling PR, Ward SA, Peeters G, Talevski J, Cumming RG, Seeman E, McNeil JJ. Aspirin and fracture risk: a systematic review and exploratory meta-analysis of observational studies. BMJ Open. 2020; Feb 20,  doi: 10.1136/bmjopen-2018-026876. aspirin, fractures, falls, bone, risks, BMD
Ryan J, Woods RL, Murray AM, Shah RC, Britt C, Reid CM, Wolfe R, Nelson MR, Lockery JE, Orchard SG, Trevaks R, Chong T, McNeil JJ, Storey E. Normative Performance of Older Individuals on the Hopkins Verbal Learning Test-Revised (HVLT-R) According to Ethno-Racial Group, Gender, Age and Education Level. The Clinical Neuropsychologist. 2020; Feb 26, doi:10.1080/13854046.2020.1730444. Alzheimer's disease, Alzheimers, cognition, dementia, cognitive, HVLTR, HVLT-R, Hopkins, verbal, delayed, recall
Agustini B, Mohebbi M, Woods RL, McNeil JJ, Nelson MR, Shah RC, Murray AM, Ernst ME, Reid CM, Tonkin A, Lockery JE, Berk M, on behalf of the ASPREE Investigator Group. The association of antihypertensive use and depressive symptoms in a large older population with hypertension living in Australia and the United States. Journal of Human Hypertension. 2020; Jan 30, doi.org/10.1038/s41371-020-0303-y. depression, CES-D, CES-D-10, CESD, depressive, cognitive, mental, mood, hypertension, blood pressure, co-morbidity, comorbidity, co-morbidities, comorbidities, antihypertensive, beta blocker, calcium channel antagonist, angiotensin
Pinese M, Lacaze P, Rath E, Stone A, Brion MJ, Ameur A, Nagpal S, Puttick C, Husson S, Degrave D, Navin Cristina T, Kahl VS, Statham A, Woods R, McNeil J, Riaz M, Barr M, Nelson M, Reid C, Murray A, Shah R, Wolfe R, Atkins J, Fitzsimmons C, Cairns H, Green M, Carr V, Cowley M, Pickett H, James P, Powell J, Kaplan W, Gibson G, Gyllensten U, Cairns M, McNamara M, Dinger M, Thomas D. The Medical Genome Reference Bank contains whole genome and phenotype data of 2,570 healthy elderly. Nature Communications Online. 2020; Jan 23, doi:10.1038/s41467-019-14079-0. Medical Genome Reference Bank, genomes, genomics, sequencing, MGRB, DNA, phenotypes, variants, genes, blood, biobank, sub-study, substudy
Voskoboinik I, Lacaze P, Jang HS, Flinsenberg TWH, Fernando SL, Kerridge I, Riaz M, Sebra R, Thia KYT, Noori T, Schadt EE, McNeil JJ, Trapani JA. Prevalence and Disease Predisposition of p.A91V perforin in an aged Caucasian Population. Blood Journal. 2020, doi:10.1182/blood-2019003487 [epub ahead of print 2020; Jan 13]. genomes, genomics, variants, genes, cancers, perforin, PRF1, biomarkers, blood, biobank
Lockery JE, Rigby J, Collyer TA, Stewart A, Woods RL, McNeil JJ, Reid CM, Ernst ME, on behalf of the ASPREE Investigator Group. Optimising medications data collection in a large-scale clinical trial. Plos One. 2019; Dec 27, doi.org/10.1371/journal.pone.0226868. medications, methodology, methods, design, poly pharmacy, data, database, quality
Chowdhury EK, Nelson MR, Ernst ME, Margolis KL, Beilin LJ, Johnston CI, Woods RL, Murray AM, Wolfe R, Storey E, Shah RC, Lockery JE, Tonkin AM, Newman AB, Williamson JD, Abhayaratna WP, Stocks NP, Fitzgerald SM, Orchard SG, Trevaks RE, Donnan GA, Grimm R, McNeil JJ, Reid CM, for the ASPREE investigator Group. Factors associated with treatment and control of hypertension in a healthy elderly population free of cardiovascular disease: a cross-sectional study. American Journal of Hypertension. 2019; Dec 06, doi.org/10.1093/ajh/hpz192. anti-hypertensives, hypertension, blood pressure, medications, prescriptions, co-morbidity, comorbidity, co-morbidities, comorbidities
Jamadar SD, Sforazzini F, Raniga P, Ferris NJ, Paton B, Bailey MJ, Brodtmann A, Yates PA, Donnan GA, Ward SA, Woods RL, Storey E, McNeil JJ, Egan GF;  ASPREE Investigator Group. Sexual Dimorphism of Resting-State Network Connectivity in Healthy Ageing. The journals of gerontology. Series B, Psychological sciences and social sciences. 2019; Oct, doi:10.1093/geronb/gby004. sex, gender, males, females, cognition, brain, cognitive, neuroscience, connectivity
Lockery JE, Collyer TA, Reid CM, Ernst ME, Gilbertson D, Hay N, Kirpach B, McNeil JJ, Nelson MR, Orchard SG, Pruksawongsin K, Shah RC, Wolfe R, Woods RL, on behalf of the ASPREE Investigator Group. Overcoming challenges to data quality in the ASPREE clinical trial. Trials. 2019; 20: 686, doi:10.1186/s13063-019-3789-2. data, quality, database, AWARD, costs, framework, methodology, methods, design
Davis SR, Bell RJ, Robinson PJ, Handelsman DJ, Gilbert T, Phung J, Desai R, Lockery JE, Woods RL, Wolfe RS, Reid CM, Nelson  MR, Murray AM, McNeil JJ. Testosterone and estrone increase from the age of 70 years; findings from the Sex Hormones in Older Women Study. J Clinical Endocrinology & Metabolism. 2019; Aug 13,  doi: 10.1210/jc.2019-00743 [epub ahead of print]. women, females, estrone, oestrone, estradiol, oestradiol, testosterone, androgen, sex hormones, blood, serum, oestrogen, postmenopause, sub-study, substudy, biobank, steroids
Agustini B, Mohebbi M, Woods RL, McNeil JJ, Nelson MR, Shah RC, Murray AM, Ernst ME, Reid CM, Tonkin A, Lockery JE, Berk M; ASPREE Investigator Group. Association Between Statin Use and Depressive Symptoms in a Large Community-Dwelling Older Population Living in Australia and the USA: A Cross-Sectional Study. CNS Drugs. 2019; May 6,  doi: 10.1007/s40263-019-00633-3 [epub ahead of print]. depression, mental, mood, statins, depressive, CES-D, CES-D-10, CESD, cholesterol, inflammation, psychiatry
Polkinghorne KR, Wolfe R, Jachno KM, Wetmore JB, Woods RL, McNeil JJ, Nelson MR, Reid CM, Murray AM; ASPREE Investigator Group. Prevalence of chronic kidney disease in the elderly using the ASPirin in Reducing Events in the Elderly study cohort. Nephrology. 2019; 24:1248-1256,  doi: 10.1111/nep.13565. CKD, renal, kidney, GFR, uACR, glomerular filtation rate, albuminuria
Mohebbi M, Agustini B, Woods RL, McNeil JJ, Nelson MR, Shah RC, Nguyen V, Storey E, Murray AM, Reid CM, Kirpach B, Wolfe RS, Lockery JE, Berk M; ASPREE Investigator Group. Prevalence of depressive symptoms and its associated factors among healthy community-dwelling older adults living in Australia and the United States. Int J Geriatr Psychiatry. 2019; Apr 16, doi: 10.1002/gps.5119 [epub ahead of print]. depression, mental, mood, depressive, CES-D, CES-D-10, CESD, sub-study, substudy, prevalence, incidence, risk factors, psychiatry
Lockery JE, Collyer TA, Abhayaratna WP, Fitzgerald SM, McNeil JJ, Nelson MR, Orchard SG, Reid C, Stocks NP, Trevaks RE, Woods RL. Recruiting general practice patients for large clinical trials: lessons from the Aspirin in Reducing Events in the Elderly (ASPREE) study. Med J Aust. 2019; 210 (4): 168-173, doi: 10.5694/mja2.12060. recruitment, recruiting, methodology, methods, design, GPs, general practice, barriers, opportunities, doctors, physicians, enrolment, enrollment
CORRESPONDENCE McNeil JJ, Woods RL, Murray AM, for the ASPREE Investigator Group. Effects of aspirin in the healthy elderly. Correspondence. N Engl J Med. 2019; 380 (18): 1776-7,  doi:10.1056/NEJMc1901774. aspirin, placebo, CVD, cardiovascular, disability, disability-free, survival, bleeds, bleeding, haemorrhages, hemorrhages, mortality, cancers, benefits, risks
COMMETARY Chan AT, McNeil J. Aspirin and Cancer Prevention in the Elderly: Where Do We Go From Here? Gastroenterology. 2019; Feb; 156(3):534-538,  doi: 10.1053/j.gastro.2018.11.063. aspirin, cancers, deaths, mortality, morbidity
McNeil JJ, Woods RL, Ward SA, Britt CJ, Lockery JE, Beilin LJ, Owen AJ. Cohort Profile: The ASPREE Longitudinal Study of Older Persons (ALSOP). International Journal of Epidemiology. 2019; Jan 08,  doi.org/10.1093/ije/dyy279. ALSOP, sub-study, substudy, longitudinal, questionnaires, physical, health, lifestyle factors, methodology, methods, design, characteristics
Lacaze P, Pinese M, Kaplan W, Stone A, Brion M, Woods RL, McNamara M, McNeil JJ, Dinger ME, Thomas DM. The Medical Genome Reference Bank: a whole-genome data resource of 4,000 healthy elderly individuals. Rationale and cohort design. European Journal of Human Genetics. 2018; Oct 24, doi: 10.1038/s41431-018-0279-z. genomics, genomes, DNA, pathogenic, genes, variants, PV, carriers, genetic testing, whole-genome, familial, methodology, methods, design, MGRB, biobank, blood, substudy, sub-study
Stocks N, González-Chica DA, Lockery JE, Shah RC, Murray AM, Wolfe R, Nelson MR, Reid CM, McNeil JJ, Woods RL, on behalf of the ASPREE Investigator Group. Quality of Life for 19,114 participants in the ASPREE (Aspirin in Reducing Events in the Elderly) Study and their association with sociodemographic and lifestyle modifiable risk factors. Quality of Life Research. 2018; Nov 08, doi: 10.1007/s11136-018-2040-z. socio demographic, lifestyle, QOL, quality, health, HRQoL, mental, SF-12, mood, physical, risk factors
McNeil JJ*, Woods RL*, Nelson MR, Reid CM, Kirpach B, Wolfe R, Storey E, Shah RC, Lockery JE, Tonkin AM, Newman AB, Williamson JD, Margolis KL, Ernst ME, Abhayaratna WP, Stocks N, Fitzgerald SM, Orchard SG, Trevaks RE, Beilin LJ, Donnan GA, Gibbs P, Johnston CI, Ryan J, Radziszewska B, Grimm R & Murray AM, on behalf of the ASPREE Investigator Group (* joint first authors). Effect of aspirin on disability-free survival in the healthy elderly. New England Journal of Medicine. 2018; 379:1499-1508, doi: 10.1056/nejmoa1800722 [published online 2018; Sept ]. aspirin, disability, disability-free, survival, health, lifespan, haemorrhages, hemorrhages, bleeds, bleeding, dementia, cognitive decline, cognition, ADLs, physical, disability, mortality, fatal, endpoints, end-points, end points, outcomes, cancers, CVD, cardiovascular, diseases, stroke, heart, depression, risk-benefit, risks, benefits, new england journal, NEJM, design, methodology, methods
McNeil JJ*, Nelson MR*, Woods RL, Lockery JE, Wolfe R, Reid CM, Kirpach B, Shah RC, Ives DG, Storey E, Ryan J, Tonkin AM, Newman AB, Williamson JD, Margolis KL, Ernst ME, Abhayaratna WP, Stocks N, Fitzgerald SM, Orchard SG, Trevaks RE, Beilin LJ, Donnan GA, Gibbs P, Johnston CI, Radziszewska B, Grimm R & Murray AM, on behalf of the ASPREE Investigator Group (* joint first authors). Effect of aspirin on all-cause mortality in the healthy elderly. New England Journal of Medicine. 2018; 379:1499-1508,  doi: 10.1056/NEJMoa1803955 [published online 2018; Sept]. aspirin, disability, disability-free, survival, health, lifespan, haemorrhages, hemorrhages, bleeds, bleeding, CVD, cardiovascular, stroke, disease, dementia, physical, mortality, morbidity, death, fatal, cancers, endpoints, end-points, end points, outcomes, risk-benefit, risks, benefits, new england journal, NEJM
McNeil JJ, Wolfe R, Woods RL, Tonkin AM, Donnan GA, Nelson MR, Reid CM, Lockery JE, Kirpach B, Storey E, Shah RC, Williamson JD, Margolis KL, Ernst ME, Abhayaratna WP, Stocks N, Fitzgerald SM, Orchard SG, Trevaks RE, Beilin LJ, Johnston CI, Ryan J, Radziszewska B, Jelinek M, Malik M, Eaton C, Brauer D, Cloud G, Wood E, Mahady SE, Satterfield S, Grimm R & Murray AM, on behalf of the ASPREE Investigator Group. Effect of aspirin on cardiovascular events and bleeding in the healthy elderly. New England Journal of Medicine. 2018; 379:1499-1508,  doi: 10.1056/nejmoa1805819 [published online 2018; Sept]. aspirin, disability, disability-free, survival, health, lifespan, haemorrhages, hemorrhages, bleeds, bleeding, CVD, cardiovascular, stroke, MACE, coronary, cardiac, heart failure, cerebral, diseases, physical, mortality, morbidity, death, fatal, endpoints, end-points, end points, outcomes, risk-benefit, risks, benefits, new england journal, NEJM
Ryan J, Woods RL, Britt C, Murray AM, Shah RC, Reid CM, Kirpach B, Wolfe RS, Nelson MR, Lockery JE, Orchard SG, Trevaks RE, McNeil JJ, Storey E, on behalf of the ASPREE Investigator Group. Normative performance of healthy older individuals on the Modified Mini-Mental State (3MS) examination according to ethno-racial group, gender, age, and education level. The Clinical Neuropsychologist. 2018,  doi.org/10.1080/13854046.2018.1488996 [published online 2018; July 05]. cognitive decline, cognition, dementia, Alzheimer's disease, Alzheimers, cognitive, MCI, aspirin, memory, 3MS, 3ms, MMMS, MMMS, characteristics
Margolis KL, Mahady SE, Nelson MR, Ives DG, Satterfield S, Britt C, Ekram S, Lockery JE, Schwartz EC, Woods RL, McNeil JJ, Wood EM. Development of a standardized definition for clinically significant bleeding in the ASPirin in Reducing Events in the Elderly (ASPREE) trial. Contemporary Clinical Trials Communications. 2018; Vol 11, 30-36, doi.org/10.1016/j.conctc.2018.05.015. aspirin, methods, methodology, design, bleeding, bleeds, haemorrhages, hemorrhages, risk-benefit, risks, benefits, endpoints, end-points, gastrointestinal, brain, cerebral, stroke
Wolfe R, Murray AM, Woods, RL, Kirpach B, Gilbertson D, Shah RC, Nelson MR, Reid CM, Ernst ME, Lockery JE, Donnan GA, Williamson J, McNeil JJ. The aspirin in reducing events in the elderly trial: Statistical analysis plan. International Journal of Stroke. 2018; Vol.13(3), pp.335-338,  doi.org/10.1177/1747493017741383. aspirin, methods, statistical analysis plan, statistics, protocol, design, disability, disability-free, survival, health, lifespan, haemorrhage, hemorrhage, bleed, CVD, cardiovascular, stroke, disease, dementia, physical, disability, mortality, morbidity, death, fatal, cancers, endpoints, end-points, end points, risk-benefit, risks, benefits
Fransquet PD, Lacaze P, Woods RL, McNeil JJ, Saffery R, Ryan J. Blood DNA methylation as a potential biomarker of dementia: a systematic review. Alzheimer’s & Dementia. 2017; 14(1): 81-103. IF:11.0, doi: 10.1016/j.jalz.2017.10.002. biomarkers, blood, DNA, DNAm, methylation, dementia, Alzheimers diease, Alzheimer's, cognition, cognitive, epigenetics, biobank
Ward SA, Storey E, Woods RL, Hamilton GS, Kawasaki R, Janke AL, Naughton MT, O’Donoghue F, Wolfe R, Wong TY, Reid CM, Abhayaratna WP, Stocks N, Trevaks R, Fitzgerald S, Hodgson LAB, Robman L,  Workman  B, McNeil JJ. The Study of Neurocognitive Outcomes, Radiological and Retinal Effects of Aspirin in Sleep Apnoea- rationale and methodology of the SNORE-ASA study. Contemporary clinical trials. 2018; Vol.64, pp.101-111,  doi.org/10.1016/j.cct.2017.10.016. cognitive decline, cognition, dementia, Alzheimer's disease, Alzheimers, cognitive, MCI, aspirin, memory, 3MS, MMMs, methods, methodology, design, apnoea, apnea, retinal, substudy, sub-study
Mohebbi M, Nguyen V, McNeil JJ, Woods RL, Nelson MR, Shah RC, Storey E, Murray AM, Reid CM, Kirpach B, Wolfe, R, Lockery JE, Berk M, on behalf of the ASPREE investigator group. Psychometric properties of a short form of the Center for Epidemiologic Studies Depression (CES-D-10) scale for screening depressive symptoms in healthy community dwelling older adults. General Hospital Psychiatry. 2018; 51:118-125, doi: 10.1016/j.genhosppsych.2017.08.002. depression, mental, mood, depressive, CES-D, CES-D-10, CESD, methods, methodology, design, psychometrics, validation, substudy, sub-study, psychiatry
McNeil JJ, Woods RL, Nelson MR, Murray AM, Reid CM, Kirpach B, Storey E, Shah RC, Wolfe R, Tonkin AM, Newman AB, Williamson JD, Lockery JE, Margolis KL, Ernst ME, Abhayaratna WP, Stocks N, Fitzgerald SM, Trevaks RE, Orchard SG, Beilin LJ, Donnan GA, Gibbs P, Johnston CI, Grimm RH, on behalf of the ASPREE investigator group. Baseline Characteristics of Participants in the ASPREE (ASPirin in Reducing Events in the Elderly) Study. J Gerontol A Biol Sci Med Sci. 2017; Oct 12, doi:10.1093/gerona/glw342. baseline, characteristics, cohort, recruitment, design, methods, methodology, disability, disability-free, survival, health, lifespan, haemorrhages, hemorrhages, dementia, cognitive decline, physical, disability, mortality, fatal, endpoint, end-point, end point, outcome, cancers, CVD, cardiovascular, disease, depression, depressive
Ward SA, Raniga P, Ferris NJ, Woods RL, Storey E, Bailey MJ, Brodtmann A, Yates PA, Donnan GA, Trevaks RE, Wolfe R, Egan GF, McNeil JJ; (Joint Senior authorship), on behalf of the ASPREE investigator group. ASPREE-NEURO study protocol: A randomized controlled trial to determine the effect of low-dose aspirin on cerebral microbleeds,white matter hyperintensities, cognition, and stroke in the healthy elderly. Int J Stroke. 2017; 12(1):108-113,  doi:10.1177/1747493016669848. aspirin, neuroimaging, dementia, cognitive decline, MRI, neuroscience, design, methods, methodology, stroke
Robman L, Guymer R, Woods RL, Ward SA, Wolfe R, Phung J, Hodgson L, Makeyeva G, Aung KZ, Gilbert T, Lockery JE, Le-Pham Y, Orchard S, Storey E, Abhayaratna W, Reid D, Ernst ME, Nelson MR, Reid C,  McNeil, JJ. Age-related macular degeneration in a randomized controlled trial of low-dose aspirin: Rationale and study design of the ASPREE-AMD study. Contemporary Clinical Trials Communications. 2017; Vol.6, pp.105-114, doi:10.1016/j.conctc.2017.03.005. aspirin, AMD, age related macular degeneration, age-related, substudy, sub-study, eye health, vision, retinal, haemorrhages, hemorrhages, design, method, methdology
Lacaze P, Ryan J, Woods RL, Winship I, McNeil JJ. Pathogenic variants in the healthy elderly: unique ethical and practical challenges. Journal of Medical Ethics. 2017; Vol. 43(10), p.714,  doi: 10.1136/medethics-2016-103967. biomarkers, genomics, genomes, DNA, pathogenic, genes, variants, PV, carriers, penetrance, genetic testing, familial, substudy, sub-study
Lacaze P, Woods RL, Zoungas S, McNeil JJ. The genomic potential of the Aspirin in Reducing Events in the Elderly and Statins in Reducing Events in the Elderly studies. Internal medicine Journal. 2017; Vol.47(4), pp.461-463, doi.org/10.1111/imj.13384. genomics, genomes, DNA, pathogenic, genes, variants, PV, carriers, penetrance, genetic testing, familial, substudy, sub-study
Eisen DP, Moore EM, Leder K,  Lockery JE, McBryde ES, McNeil JJ, Pilcher D, Wolfe R, Woods RL. AspiriN To Inhibit SEPSIS (ANTISEPSIS) randomised controlled trial protocol. BMJ Open. 2017;7:e013636,  doi: 10.1136/bmjopen-2016-013636. aspirin, sepsis, death, mortality, hospitalisation, hospitalization, design, methods, methodology, protocol, substudy, sub-study
Lacaze P, Winship I, McNeil J. Penetrance and the Healthy Elderly. Genet Test Mol Biomarkers. 2017; Nov 21(11):637-640,  doi: 10.1089/gtmb.2017.0126 [epub 2017 Sept 6]. genomics, genome, DNA, pathogenic, genes, variants, PV, carriers, penetrance, genetic testing, familial, substudy, sub-study
Berk M, Woods RL, Nelson MR, Shah RC, Reid CM, Storey E, Fitzgerald SM, Lockery JE, Wolfe R, Mohebbi M, Murray AM, Kirpach B, Grimm R, McNeil JJ. ASPREE-D: Aspirin for the prevention of depression in the elderly. International Psychogeriatrics. 2016,  doi:10.1017/S104161021600079X. aspirin, depression, CES-D, CES-D-10, CESD, depressive, cognitive, mood, mental, methods, methodology, design, substudy, sub-study, protocol, psychiatry
Lowthian JA, Britt CJ, Rance G, Lin FR, Woods RL, Wolfe R, Nelson MR, Dillon HA, Ward S, Reid CM, Lockery JE, Nguyen TT, McNeil JJ, Storey E. Slowing the progression of age-related hearing loss: Rationale and study design of the ASPIRIN in HEARING, retinal vessels imaging and neurocognition in older generations (ASPREE-HEARING) trial. Contemp Clin Trials. 2015; 46; 60-66, doi: 10.1016/j.cct.2015.11.014. aspirin, hearing loss, cognitive, cognition, retinal, audiometry, ARHL, design, methods, methodology, substudy, sub-study
Barker AL, McNeil JJ, Seeman E, Ward SA, Sanders KM, Khosla S, Cumming RG, Pasco JA, Bohensky MA, Ebeling PR, Woods RL, Lockery JE, Wolfe R, Talevski J, and the ASPREE Investigator Group. A randomised controlled trial of low-dose aspirin for the prevention of fractures in healthy older people: protocol for the ASPREE-Fracture substudy. Inj Prev. 2015; pii: injuryprev-2015-041655, doi: 10.1136/injuryprev-2015-041655 [epub ahead of print]. PMID: 26002770 aspirin, fractures, falls, bone, BMD, methods, methodology, design, substudy, sub-study
COMMENTARY Chong EW, Guymer RH, Robman LD. Does aspirin increase the risk of age-related macular degeneration? Expert Opinion on Drug Safety. 2014; 13:691-3, doi: 10.1517/14740338.2014.914169. aspirin, AMD, age related macular degeneration, age-related, eye health, vision, retinal, haemorrhage, hemorrhage, design, method, methdology, substudy, sub-study
ASPREE Investigator Group. Study design of ASPirin in Reducing Events in the Elderly (ASPREE): a randomized, controlled trial. Contemporary Clinical Trials. 2013; 36: 555–564, doi: org/10.1016%2Fj.cct.2013.09.014. aspirin, recruitment, GPs, general practice, methods, methodology
COMMENTARY Nelson MR. General practice-based clinical trials. Perspectives, Med J Aust. 2013; 198 (3), doi: 10.5694/mja12.11061. recruitment, GPs, general practice, methods, methodology
Reid CM, Storey E, Wong TY, Woods RL, Tonkin A, Wang JJ, Kam A, Janke A, Essex R, Abhayaratna WP, Budge MM, on behalf of the ASPREE Study Group. Aspirin for the prevention of cognitive decline in the elderly: rationale and design of a neuro-vascular imaging study (ENVIS-ion). BMC Neurol. 2012; 12:3, doi: 10.1186/1471-2377-12-3. envision, en-vision, cognitive decline, cognition, dementia, neuro, MRI, retinal, design, methods, methodology, substudy, sub-study
Linden MD, Tran HA, Woods RL, Tonkin AM. High platelet reactivity and antiplatelet therapy resistance. Seminars in Thrombosis and Hemostasis. 2012; 38(2):200-12, doi: 10.1055/s-0032-1301417. aspirin, anti-platelet, antiplatelet, resistance, thrombosis, CVD, cardiovascular
COMMENTARY Ward SA, Demos L, Workman B, McNeil JJ. Aspirin for primary prevention of cardiovascular events in the elderly: current status and future directions. Drugs Aging. 2012; Apr 1;29(4):251-8, doi.org/10.2165/11599030-000000000-00000. aspirin, anti-platelet, antiplatelet, resistance, thrombosis, CVD, cardiovascular, cardiac
EDITORIAL Woods RL, Tonkin AM, Nelson MR, Britt HC, Reid CM. Should aspirin be used for the primary prevention of cardiovascular disease in people with diabetes? Med J Aust. 2009; 190:614-5  PMID:19485837 aspirin, CVD, cardiovascular, stroke, heart, cardiac, diabetes
Nelson MR, Reid CM, Ames DA, Beilin LJ, Donnan GA, Gibbs P, Johnston CI, Krum H, Storey E, Tonkin A, Wolfe R, Woods R, McNeil JJ. Feasibility of conducting a primary prevention trial of low-dose aspirin for major adverse cardiovascular events in older people in Australia: results from the ASPirin in Reducing Events in the Elderly (ASPREE) pilot study. Med J Aust. 2008; 189:105-109, doi.org/10.5694/j.1326-5377.2008.tb01932.x. PMID:18637782 aspirin, design, method, methodology, CVD, cardiovascular, stroke, heart, cardiac, pilot
Nelson MR, Liew D, Bertram M, Vos T. Epidemiological modelling of routine use of low-dose aspirin in Australia for the primary prevention of coronary heart disease and stroke in those aged 70 years and above. BMJ. 2005; 330:1306-1308, doi: 10.1136/bmj.38456.676806.8F. aspirin, design, method, methodology, CVD, cardiovascular, stroke, heart, cardiac
CONFERENCE PROCEEDINGS Nelson MR, Reid CM, Johnstone CI, Krum H, Storey E, Tonkin A, Beilin LJ, Donnan GA, McNeil JJ.  After ANBP2 – ASPREE  Clinical And Experimental Pharmacology And Physiology, Melbourne, Australia. 2003, Vol.30(7), pp.A59-A59. aspirin, design, method, methodology, GPs, general practice, ANBP2
ASPREE Study Group. Nelson MR, Reid CM, Beilin LJ, Donnan GA, Johnston CI, Krum H, Storey E, Tonkin AM, McNeil JJ.  Rationale for a primary prevention trial in the elderly of low dose aspirin for the prevention of major adverse cardiovascular events and vascular dementia in Australian general practice.  ASPirin in Reducing Events in the Elderly (ASPREE). J Drugs and Aging. 2003; 20(12):897-903, doi: 10.2165/00002512-200320120-00004. aspirin, design, method, methodology, CVD, cardiovascular, stroke, heart, cardiac, dementia, vascular, cognitive decline, GP, general practice, recruitment
Silagy CA, McNeil JJ, Donnan GA, Tonkin AM, Worsam B, Campion K. The PACE pilot study: 12-month results and implications for future primary prevention trials in the elderly. (Prevention with low-dose Aspirin of Cardiovascular disease in the Elderly). J Am Geriatr Soc. 1994; 42(6):643-64, doi: 10.1111/j.1532-5415.1994.tb06864.x. aspirin, cardiac, cardiovascular, pilot, aspirin, design, methodology
Silagy CA, McNeil JJ, Donnan GA, Tonkin AM, Worsam B, Campion K. Adverse effects of low-dose aspirin in a healthy elderly population. Clin Pharmacol Ther. 1993; 54(1):84-89, doi: 10.1038/clpt.1993.115. aspirin, adverse, risk, methodology, design, effects
Silagy CA, McNeil JJ, Bulpitt CJ, Donnan GA, Tonkin AM, Worsam B. Rationale for a primary prevention study using low-dose aspirin to prevent coronary and cerebrovascular disease in the elderly. J Am Geriatr Soc. 1991; 39(5):484-491, doi: 10.1111/j.1532-5415.1991.tb02494.x. aspirin, cardiac, cardiovascular, stroke, CVD, CVA, design, methodology
Campion K, Silagy CA, McNeil JJ, Donnan GA, Tonkin AM, Worsam B. Comparison of recruitment strategies for a large-scale multicentred clinical trial in the elderly. Community Health Stud. 1990; 14(4):400, doi: 10.1016/0895-4356(91)90013-y. recruitment, design, methodology

2022

  • Collyer TA, Murray AM, Woods RL, Storey E, Chong TJ, Ruan J, Orcahrd SG, Brdotmann A, Srikanth VK, Shah RC, Callisaya ML. Association of Dual Decline in Cognition and Gait Speed With Risk of Dementia in Older Adults. JAMA Netw Open. 2022; May 31, doi:10.1001/jamanetworkopen.2022.14647. Accompanying EDITORIAL 2022; May 31, doi: 10.1001/jamanetworkopen.2022.14654.
  • Downie JM, Riaz M, Xie J, Lee M, Chan AT, Gibbs P, Orchard SG, Mahady SE, Sebra RP, Murray AM, Macrae F, Schadt E, Woods RL, McNeil JJ, Lacaze P, Gala M. Incident Cancer Risk and Signatures Among Older MUTYH Carriers: Analysis of Population-Based and Genomic Cohorts. Cancer Prev Res (Phila). 2022; May 31, doi: 10.1158/1940-6207.CAPR-22-0080.
  • Hu Y, Carr PR, Liew D, Broder J, Callander EJ, McNeil JJ. How does the onset of physical disability or dementia in older adults affect economic wellbeing and co-payments for health care? The impact of gender. BMC Health Serv Res. 2022; May 25, doi: 10.1186/s12913-022-08017-y.
  • Ward SA, Storey E, Gasevic D, Naughton MT, Hamilton GS, Trevaks RE, Wolfe R, O’Donoghue F, Stocks N, Abhayaratna WP, Fitzgerald S, Orchard SG, Ryan J, McNeil JJ, Reid CM, Woods RL. Sleep-disordered breathing was associated with lower health-related quality of life and cognitive function in a cross-sectional study of older adults. Respirology. 2022; May 17, doi.org/10.1111/resp.14279.
  • Lacaze P, Wang Y, Polekhina G, Bakshi A, Riaz M, Owen A, Franks A, Abidi J, Tiller J, McNeil J, Cicuttini F. Genomic risk score for advanced osteoarthritis in older adults. Arthritis Rheumatol. 2022; May 4, doi: 10.1002/art.42156 [online ahead of print].
  • Agustini B, Lotfaliany M, Mohebbi M, Woods RL, McNeil JJ, Nelson MR, Shah R, Murray A, Reid CM, Tonkin A, Ryan J, Williams LJ, Forbes MP, Berk M. Trajectories of depressive symptoms in older adults and associated health outcomes. Nat Aging. 2022; Apr 19, doi.org/10.1038/s43587-022-00203-1.
  • Jadhao S, Davison C, Roulis EV, Lee S, Lacaze P, Riaz M, McNeil JJ, Thomas DM, Pecheniuk NM, Hyland CA, Flower R, Nagaraj SH. Using Whole Genome Sequencing to Characterize Clinically Significant Blood Groups Among Healthy Older Australians. Blood Adv. 2022; Apr 14, doi: 10.1182/bloodadvances.2022007505.
  • Polkinghorne KR, Wetmore JB, Thao LTP, Wolfe R, Woods RL, Ernst ME, Nelson MR, Reid CM, Shah RC, McNeil JJ, Murray AM. Effect of Aspirin on CKD Progression in Older Adults: Secondary Analysis From the ASPREE Randomized Clinical Trial. American Journal of Kidney Diseases. 2022; Apr 14, doi: 10.1053/j.ajkd.2022.02.019 [pre-proof].
  • Neumann JT, Thao LTP, Murray AM, Callander E, Carr PR, Nelson MR, Wolfe R, Woods RL, Reid CM, Shah RC, Newman AB, Williamson JD, Tonkin AM, McNeil JJ. Prediction of disability-free survival in healthy older people. GeroScience. 2022; Apr 14, doi.org/10.1007/s11357-022-00547-x.
  • Craig H, Ryan J, Freak-Poli R, Owen A, McNeil J, Woods RL, Britt C, Tonkin A, Gasevic D. The Association of Dispositional Optimism and Pessimism With Cardiovascular Disease Events in Older Adults: A Prospective Cohort Study. J Aging Health. 2022, doi: 10.1177/08982643221083118 [online ahead of print, 2022; Apr 11].
  • Yan MK, Orchard SG, Adler NR, Wolfe R, McLean C, Rodriguez LM, Woods RL, Gibbs P, Chan AT, Haydon A, Mar VJ. Effect of Aspirin on Melanoma Incidence in Older Persons: Extended Follow-up of a Large Randomized Double-blind Placebo-controlled Trial. Cancer Prev Res (Phila). 2022; Apr 8, doi: 10.1158/1940-6207.CAPR-21-0244 [epub ahead of print]. PMID: 35395069
  • Zhou Z, Nelson M, Ernst ME, Reid C, McNeil J, Tonkin A, on behalf of the ASPREE Investigator Group. Does aspirin prevent incident heart failure in healthy older adults? Examining the evidence from the ASPREE trial. Circulation: Heart Failure 2022; Apr 5, doi: 510.1161/CIRCHEARTFAILURE.122.009511.
  • Wrigglesworth J, Harding I, Ward P, Woods RL, Storey E, Fitzgibbon B, Egan G, Murray A, Shah R, Trevaks R, Ward S, McNeil JJ, Ryan J. Factors Influencing Change in Brain-Predicted Age Difference in a Cohort of Healthy Older Individuals. Journal of Alzheimer’s Disease Reports. 2022; April 4, doi:10.3233/ADR-220011.
  • Bakshi A, Cao Y, Orchard SG, Carr PR, Joshi AD, Manning AK, Buchanan DD, Umar A, Winship IM, Gibbs P, Zalcberg JR, Macrae F, McNeil JJ, Lacaze P, Chan A.  Aspirin and the risk of colorectal cancer according to genetic susceptibility among older individuals. Cancer Prev Res (Phila). 2022; Mar 29, doi: 10.1158/1940-6207.CAPR-22-0011 [epub ahead of print].
  • Ekram ARMS, Woods RL, Ryan J, Espinoza SE, Gilmartin-Thomas JFM, Shah RC, Mehta R, Kochar B, Lowthian JA, Lockery J, Orchard S, Nelson M, Fravel MA, Liew D, Ernst ME. The association between polypharmacy, frailty and disability-free survival in community-dwelling healthy older individuals. Archives of Gerontology and Geriatrics. 2022; Mar 23, doi: 10.1016/j.archger.2022.104694  [epub ahead of print].
  • Phyo AZZ, Gonzalez-Chica DA, Stocks NP, Woods RL, Tran T, Reid CM, Tonkin AT, Nelson MR, McNeil JJ, Murray AM, Gasevic D, Freak-Poli R, Ryan J. Trajectories of physical health-related quality of life and the risk of incident cardiovascular disease events and all-cause mortality in older people. American Heart Journal Plus: Cardiology Research and Practice. 2022, doi: 10.1016/j.ahjo.2022.100117 [published online 2022; Mar 23].
  • Nelson MR, Polekhina G, Woods RL, Reid CR, Tonkin AM, Wolfe R, Murray AM, Kirpach B, Ernst ME, Lockery JE, Shah RC, Stocks N, Orchard SG, Zhou Z. Safety of Ceasing Aspirin Used Without a Clinical Indication After Age 70 Years: A Subgroup Analysis of the ASPREE Randomized Trial. Ann Intern Med. 2022; Mar 15, doi: 10.7326/M21-3823 [epub ahead of print]. Accompanying editorial, doi: 10.7326/M22-0550.
  • Muhandiramge J, Orchard SG, Warner ET, van Londen GJ, Zalcberg JR. Functional Decline in the Cancer Patient: A Review. Cancers. 2022; Mar 8, doi.org/10.3390/cancers14061368.
  • Islam RM, Bell RJ, Handelsman DJ, McNeil JJ, Nelson MR, Reid CM, Tonkin AM, Wolfe RS, Woods RL, Davis SR. Associations between blood sex steroid concentrations and risk of major adverse cardiovascular events in healthy older women in Australia: a prospective cohort substudy of the ASPREE trial. Lancet Healthy Longev. 2022; Feb 1, doi:10.1016/S2666-7568(22)00001-0. Accompanying editorial, doi.org/10.1016/S2666-7568(22)00008-3.
  • Neumann JT, Thao LTP, Callander E, Carr PR, Qaderi V, Nelson MR, Reid CR, Woods RJ. Orchard SG, Wolfe R, Polekhina G, Williamson JMR, Trauer JM, Newman AB, Murray AM, Ernst ME, Tonkin AM, McNeil JJ. A multistate model of health transitions in older people: a secondary analysis of ASPREE clinical trial data. Lancet Healthy Longev. 2022; Feb 1, doi:10.1016/S2666-7568(21)00308-1. Accompanying editorial, doi.org/10.1016/S2666-7568(22)00011-3.
  • Govindaraju T, McCaffrey TA, McNeil JJ, Reid CM, Smith BJ, Campbell DJ, Liew D, Owen AJ. Quality of life and associations with health-related behaviours among older adults with increased cardiovascular risk. Nutrition, Metabolism and Cardiovascular Diseases. 2022; Jan 29, doi: 10.1016/j.numecd.2022.01.025 [epub ahead of print].

2021

  • Neumann JT, Riaz M, Bakshi A, Polekhina G, Thao LTP, Nelson MR, Woods RL, Abraham G, Inouye M, Reid CM, Tonkin AM, McNeil J, Lacaze P. Prognostic Value of a Polygenic Risk Score for Coronary Heart Disease in Individuals Aged 70 Years and Older. Circ Genom Precis Med. 2021; Dec 24, doi: 10.1161/CIRCGEN.121.003429 [epub ahead of print].
  • Freak-Poli R, Ryan J, Neumann JT, Tonkin A, Reid CM, Woods RL, Nelson M, Stocks N,  Berk M, McNeil J, Britt C, Owen A. Social isolation, social support and loneliness as predictors of cardiovascular disease incidence and mortality. BMC Geriatr. 2021; Dec. 13, doi.org/10.1186/s12877-021-02602-2.
  • Riaz M, Mattisson J, Polekhina G, Bakshi A, Halvardson J, Danielsson M, Ameur A, McNeil J, Forsberg LA, Lacaze P.  A polygenic risk score predicts mosaic loss of chromosome Y in circulating blood cells. Cell Biosci. 2021; Dec. 12, doi.org/10.1186/s13578-021-00716-z.
  • Southey MC, Dowty JG, Riaz M, Steen JA, Renault AL, Tucker K, Kirk J, James P, Winship I, Pachter N, Poplawski N, Grist S, Park DJ, Pope BJ, Mahmood K, Hammet F, Mahmoodi M, Tsimiklis H, Theys D, Rewse A, Willis A, Morrow A, Speechly C, Harris R, Sebra R, Schadt E, Lacaze P, McNeil JJ, Giles GG, Milne RL, Hopper JL, Nguyen-Dumont T. Population-based estimates of breast cancer risk for carriers of pathogenic variants identified by gene-panel testing. NPJ Breast Cancer. 2021; Dec 9, doi: 10.1038/s41523-021-00360-3.
  • Murray AM, Thao LTP, Ryan J, Wolfe R, Wetmore JB, Woods RL, Polkinghorne KR. Chronic kidney disease biomarkers, cognitive impairment and incident dementia in an older healthy cohort. Kidney360. 2021; Dec. 7. doi.org/10.34067/KID.0005672021. Epub ahead of print.
  • Broder, JC, Ryan, J, Shah, RC, Lockery JE, Orchard SG, Gilmartin-Thomas JFM, Fravel MA, Owen AJ, Woods RL, Wolfe R, Storey E, Murray AM, Ernst ME. Anticholinergic medication burden and cognitive function in participants of the ASPREE study. Pharmacotherapy. 2021; Dec. 6, doi:10.1002/phar.2652.
  • Selvadurai MV, Riaz M, Xie S, Tonkin A, McNeil JJ, Lacaze P, Hamilton J. The PAR4 platelet thrombin receptor variant rs773902 does not impact the incidence of thrombotic or bleeding events in a healthy older population. Thromb Haemost. 2021 Dec 1, doi: 10.1055/a-1711-1395 [epub ahead of print]. PMID: 34852379
  • Bakshi A, Riaz M, Orchard SG, Carr PR, Joshi AD, Cao Y, Rebello R, Nguyen-Dumont T, Southey MC, Millar JL, Gately L, Gibbs P, Ford LG, Parnes HL, Chan AT, McNeil JJ, Lacaze P. A Polygenic Risk Score Predicts Incident Prostate Cancer Risk in Older Men but Does Not Select for Clinically Significant Disease. Cancers. 2021; Nov 19, doi: 10.3390/cancers13225815.
  • Neumann JT, Thao LTP, Callander E, Chowdhury E, Williamson JD, Nelson MR, Donnan G, Woods RL, Reid CR, Poppe KK, Jackson R, Tonkin AM, McNeil JJ. Cardiovascular risk prediction in healthy older people. GeroScience. 2021; Nov 11, doi: 10.1007/s11357-021-00486-z.
  • Espinoza SE, Woods RL, Ekram ARMS, Ernst ME, Polekhina G, Wolfe R, Shah RC, Ward SA, Storey E, Nelson MR, Reid CM, Lockery JE, Orchard SG, Trevaks R, Fitzgerald SM, Stocks NP, Chan A, McNeil JJ, Murray AM, Newman AB, Ryan J; ASPREE Investigator Group. The effect of low-dose aspirin on frailty phenotype and frailty index in community-dwelling older adults in the ASPirin in Reducing Events in the Elderly study. J Gerontol A Biol Sci Med Sci. 2021; Nov 10:glab340, doi: 10.1093/gerona/glab340 [epub ahead of print]. PMID: 34758073
  • Joyce J, Ryan J, Owen A, Hu J, McHugh Power J, Shah R, Woods RL, Storey E, Britt C, Freak-Poli R, ASPREE Investigator Groupl. Social isolation, social support, and loneliness and their relationship with cognitive health and dementia. Int J Geriatr Psychiatry. 2021; Nov 5, doi: 10.1002/gps.5644.
  • Neumann JT, Freak-Poli R, Orchard SG, Wolfe R, Reid CM, Tonkin AM, Beilin LJ, McNeil JJ, Ryan J, Woods RL. Alcohol consumption and risks of cardiovascular disease and all-cause mortality in healthy older adults. European Journal of Preventive Cardiology. 2021; Oct 28, doi: 10.1093/eurjpc/zwab177.
  • Phyo AZZ, Gonzalez-Chica DA, Stocks N,  Woods RLW, Fisher J, Tran T, Owen A, Ward S, Britt C, Ryan J, Freak-Poli R. Impact of economic factors, social health and stressful life events on physical health-related quality of life trajectories in older Australians. Qual Life Res. 2021; Oct 22, doi: 10.1007/s11136-021-03021-x.
  • Wrigglesworth J, Yaacob N, Ward P, Woods RL, McNeil JJ, Storey E, Egan G, Murray A, Shah RC, Jamadar SD, Trevaks T, Ward W, Harding IH, Ryan J. Brain-predicted age difference is associated with cognitive processing in later-life. Neurobiology of Aging. 2021; Oct 20, doi: 10.1016/j.neurobiolaging.2021.10.007 [epub ahead of print].
  • Craig HJ, Ryan J, Freak-Poli R, Owen A, McNeil J, Woods R, Ward S, Britt C, Gasevic D. Dispositional Optimism and All-Cause Mortality in Older Adults: A Cohort Study. Psychosom Med. 2021; Oct 1 ;83(8):938-945. doi: 10.1097/PSY.0000000000000989. PMID: 34334727
  • Lin X, Banaszak-Holl J, Xie J, Ward SA, Brodaty H, Storey E, Shah RC, Murray A, Ryan J, Orchard SG, Fitzgerald SM, McNeil JJ. Similar mortality risk in incident cognitive impairment and dementia: Evidence from the ASPirin in Reducing Events in the Elderly (ASPREE) trial. J Am Geriatrics Soc. 2021; Sept 17, doi: 10.1111/jgs.17435.
  • Ernst ME, Fravel MA, Webb KL, Wetmore JB, Wolfe R, Chowdhury E, Reid CM, Woods RL, Beilin L, Margolis KL, Murray AM, Polkinghorne KR; ASPirin in Reducing Events in the Elderly Investigator Group. Long-term Blood Pressure Variability and Kidney Function in Participants of the ASPREE Trial. Am J Hypertens. 2021; Sept. 14, doi: 10.1093/ajh/hpab143 [epub ahead of print].  Accompanying EDITORIAL 2021; Oct 8, doi: doi.org/10.1093/ajh/hpab160.
  • Fransquet PD, Lacaze P, Saffery R, Shah RC, Vryer R, Murray A, Woods RL, Ryan J. Accelerated Epigenetic Aging in Peripheral Blood Does not Predict Dementia Risk. Curr Alzheimer Res. 2021; Aug. 22, doi: 10.2174/1567205018666210823100721 [epub ahead of print]. PMID: 34429046
  • Huq AJ, Fulton-Howard B, Riaz M, Laws S, Sebra R, Ryan J; Alzheimer’s Disease Genetics Consortium, Renton AE, Goate AM, Masters CL, Storey E, Shah RC, Murray A, McNeil J, Winship I, James PA, Lacaze P. Polygenic score modifies risk for Alzheimer’s disease in APOE ε4 homozygotes at phenotypic extremes. Alzheimers Dement (Amst). 2021; Aug. 5, doi: 10.1002/dad2.12226. eCollection 2021.
  • Ryan J, Espinoza S,  Ernst ME, Saifuddin Ekram ARM, Wolfe R, Murray AM, Shah RC, Orchard SG, Fitzgerald S, Beilin LJ, Ward SA, Williamson JD, Newman AB, McNeil JJ, Woods RL, on behalf of the ASPREE Investigator Group. Validation of a deficit-accumulation Frailty Index in the ASPREE study and its predictive capacity for disability-free survival. Journals of Gerontology: Series A. 2021; Aug. 02, doi.org/10.1093/gerona/glab225.
  • Lacaze P, Riaz M, Sebra R, Hooper AJ, Pang J, Tiller J, Polekhina G, Tonkin A, Reid C, Zoungas S, Murray AM, Nicholls S, Watts G, Schadt E, McNeil JJ. Protective lipid-lowering genetic variants in healthy older individuals without coronary heart disease. Open Heart. 2021; Aug. 02, doi: 10.1136/openhrt-2021-001710.
  • Lacaze P, Bakshi A, Riaz M, Orchard SG, Tiller J, Neumann JT, Carr PR, Joshi AD, Cao Y, Warner ET, Manning A, Nguyen-Dumont T, Southey MC, Milne RL, Ford L, Sebra R, Schadt E, Gately L, Gibbs P, Thompson BA, Macrae FA, James P, Winship I, McLean C, Zalcberg JR, Woods RL, Chan AT, Murray AM, McNeil JJ. Genomic Risk Prediction for Breast Cancer in Older Women. Cancers. 2021 July 14; 13(14):3533, doi.org/10.3390/cancers13143533.
  • Hu J, Fitzgerald SM, Owen AJ, Ryan J, Joyce J, Chowdhury E, Reid CM, Britt C, Woods RL, McNeil JJ, Freak-Poli R. Social isolation, social support, loneliness and cardiovascular disease risk factors: a cross-sectional study among older adults. Int J Geriatr Psychiatry. 2021 July 7; 1-15, doi: /10.1002/gps.5601.
  • Phyo AZZ, Ryan J, Gonzalez-Chica DA, Stocks NP, Reid CM, Tonkin AM, Woods RL, Nelson MR, Murray AM, Gasevic D, Freak-Poli R. Health-related quality of life and incident cardiovascular disease events in community-dwelling older people: A prospective cohort study. International Journal of Cardiology. 2021, doi: /10.1016/j.ijcard.2021.07.004 [published online, 2021 July 7].
  • Zhou Z, Ryan J, Ernst ME, Zoungas S, Tonkin AM, Woods RL, McNeil JJ, Reid CM, Curtis AJ, Wolfe R, Wrigglesworth J, Shah RC, Storey E, Murray A, Orchard SG, Nelson MR. Effect of statin therapy on cognitive decline and incident dementia in older adults, J Am Coll Cardiol 2021 June 29; 77(25): 3145-56, doi:10.1016/j.jacc.2021.04.075.
  • Ernst ME, Ryan J, Chowdhury EK, Margolis KL, Beilin LJ, Reid CM, Nelson MR, Woods RL, Shah RC, Orchard SG, Wolfe R, Storey E, Tonkin AM, Brodtmann A, McNeil JJ, Murray AM. Long-Term Blood Pressure Variability and Risk of Cognitive Decline and Dementia Among Older Adults. J Am Heart Assoc 2021, June 26 ;10:e019613, doi: 10.1161/JAHA.120.019613.
  • Lacaze P, Sebra R, Riaz M, Ingles J, Tiller J, Thompson BA, James PA, Fatkin D, Semsarian C, Reid CM, Tonkin AM, Winship I, Schadt E, McNeil JJ. Genetic variants associated with inherited cardiovascular disorders among 13,131 asymptomatic older adults of European descent. NPJ Genom Med. 2021 June 16; 6(1):51, doi: 10.1038/s41525-021-00211-x. PMID: 34135346; PMCID: PMC8209162.
  • Neumann JT, Riaz M, Bakshi A, Polekhina G, Thao LTP, Nelson MR, Woods RL, Abraham G, Inouye M, Reid CM, Tonkin AM, Williamson JD, Donnan G, Brodtmann A, Cloud GC, McNeil JJ, Lacaze P. Predictive performance of a polygenic risk score for incident ischemic stroke in a healthy older population. Stroke 2021;52, doi:10.1161/STROKEAHA.120.033670 [epub ahead of print, May 27].
  • Riaz M, Huq A, Ryan J, Orchard SG, Tiller J, Lockery J, Woods RL, Wolfe R, Renton AE, Goate AM, Sebra R, Schadt E, Brodtmann A, Shah RC, Storey E, Murray AM, McNeil JJ, Lacaze P. Effect of APOE and a polygenic risk score on incident dementia and cognitive decline in a healthy older population. Aging Cell. 2021, doi: 10.1111/acel.13384. [epub ahead of print, May 26] PMID: 34041846.
  • Nunn JS, Sulovski M, Tiller J, Holloway B, Ayton D, Lacaze P. Involving elderly research participants in the co-design of a future multi-generational cohort study. Research Involvement and Engagement 7:23. 2021 May 3, doi.org/10.1186/s40900-021-00271-4
  • Wu Z, Woods RL, Wolfe R, Storey E, Chong TTJ, Shah RC, Orchard SG, McNeil JJ, Murray AM, Ryan J; the ASPREE Investigator Group. Trajectories of cognitive function in community‐dwelling older adults: A longitudinal study of population heterogeneity. Alzheimer’s Dement. 2021 May 2,  doi: org/10.1002/dad2.12180.
  • Muhandiramge J, Orchard S, Haydon A, Zalcberg J. The acceleration of ageing in older patients with cancer. J Geriatr Oncol. 2021; April, doi: 10.1016/j.jgo.2020.09.010. [epub 2020 Sep 12]. PMID: 32933870
  • Bakshi A, Yan M, Riaz M, Polekhina G, Orchard SG, Tiller J, Wolfe R, Joshi A, Cao Y, McInerney-Leo AM, Yanes T, Janda M, Soyer HP, Cust AE, Law MH, Gibbs P, McLean C, Chan AT, McNeil JJ, Mar VJ, Lacaze P. Genomic Risk Score for Melanoma in a Prospective Study of Older Individuals. J Natl Cancer Inst. 2021, doi: 10.1093/jnci/djab076 [epub ahead of print, 2021 April 10].
  • Nguyen-Dumont T, Dowty JG, MacInnis RJ, Steen JA, Riaz M, Dugue PA, Renault AL, Hammet F, Mahmoodi M, Theys D, Tsimiklis H, Severi G, Bolton D, Lacaze P, Sevra R, Schadt E, McNeil J, Giles GG, Milne RL, Southey MC. Rare germline pathogenic variants identified by multigene panel testing and the risk of aggressive prostate cancer. Cancers 2021; Mar. 24, doi: 10.3390/cancers13071495.
  • Lockery JE, Broder JC, Ryan J, Stewart AC, Woods RL, Chong TT, Cloud GC, Murray A, Rigby JD, Shah R, Storey E, Ward SA, Wolfe R, Reid CM, Collyer TA, Ernst ME; the ASPREE Investigator Group. A Cohort Study of Anticholinergic Medication Burden and Incident Dementia and Stroke in Older Adults. J Gen Intern Med. 2021, doi: 10.1007/s11606-020-06550-2 [published online, 2021 Mar. 22]. PMID: 33754317
  • Phyo AZZ, Gonzalez-Chica DA, Stocks NP, Storey E, Woods RL, Murray AM, Orchard SG, Shah RC, Gasevic D, Freak-Poli R, Ryan J; ASPREE Investigator Group. The Utility of Assessing Health-Related Quality of Life to Predict Cognitive Decline and Dementia. J Alzheimers Dis. 2012, doi: 10.3233/JAD-201349 [epub ahead of print 2021 Feb. 12]. PMID: 33579847
  • EDITORIAL McNeil JJ. Aspirin and primary prevention of colorectal cancer: a still evolving story. JNCI: Journal of the National Cancer Institute, 2021;djab010, doi.org/10.1093/jnci/djab010 [published online, 2021 Feb. 02].
  • Berk M, Agustini B, Woods RL, Nelson MR, Shah RC, Reid CM, Storey E, Fitzgerald S, Lockery JE, Wolfe R, Mohebbi M, Dodd S, Murray AM, Stocks N, Fitzgerald P, Mazza C, McNeil JJ. Effects of aspirin on the long-term management of depression in older people: a double-blind randomised placebo-controlled trial. Mol Psychiatry 2021,  doi.org/10.1038/s41380-021-01020-5 [published online, 2021 Jan. 27].
  • Phyo AAZ, Ryan J, Gonzalez-Chica DA, Woods RL, Reid CM, Nelson MR, Murray AM, Gasevic D, Stocks NP, Freak-Poli R; the ASPREE Investigator Group. Health-related quality of life and all-cause mortality among older health individuals in Australia and the United States: a prospective cohort study. Quality of Life Research 2021; 30(4):1037-48, doi:10.1007/s11136-020-02723-y [published online, 2021 Jan. 03].

2020

  • Woods RL, Espinoza S, Thao LTP, Ernst ME, Ryan J, Wolfe R, Shah RC, Ward SA, Storey E, Nelson MR, Reid CM, Lockery JE, Orchard SG, Trevaks RE, Fitzgerald SM, Stocks NP, Williamson JD, McNeil JJ, Murray AM, Newman AB; ASPREE Investigator Group. Effect of Aspirin on Activities of Daily Living Disability in Community-Dwelling Older Adults. J Gerontol A Biol Sci Med Sci. 2020; glaa316, doi:10.1093/gerona/glaa316 [published online ahead of print, 2020 Dec. 26].
  • Islam RM, Bell RJ, Handelsman DJ, Robinson PJ, Wolfe R, Davis SR; ASPREE Investigator Group. Longitudinal changes over three years in sex steroid hormone levels in women aged 70 years and over. Clin Endocrinol (Oxf). 2020; Dec. 22, doi: 10.1111/cen.14401 [epub ahead of print]. PMID: 33351205
  • Lefevre A, Hopper I, McNeil JJ, Owen A; ALSOP Complementary Medicine Research Group. Complementary medicine use by community-dwelling older Australians [published online ahead of print, 2020 Dec 10]. Med J Aust. 2020; 10.5694/mja2.50884, doi:10.5694/mja2.50884 [published online ahead of print, 2020 Dec. 9].
  • Gilmartin-Thomas JF, Forbes A, Liew D, McNeil JJ, Cicuttini FM, Owen AJ, Ernst ME, Nelson MR, Lockery J, Ward SA, Busija L; ASPREE Investigator Group. Evaluation of the Pain Impact Index for community-dwelling older adults through the application of Rasch modelling. Pain Pract. 2020; Dec. 9, doi: 10.1111/papr.12980 [epub ahead of print]. PMID: 33295122
  • Chowdhury EK, Ernst ME, Nelson M, Margolis K, Beilin LJ, Johnston C, Woods R, Murray A, Wolfe R, Storey E, Shah RC, Lockery J, Tonkin A, Newman A, Abhayaratna W, Stocks N, Fitzgerald S, Orchard S, Trevaks R, Donnan G, Grimm R, McNeil J, Reid CM; ASPREE Investigator Group. Impact of the 2017 American Heart Association and American College of Cardiology hypertension guideline in aged individuals. J Hypertens. 2020 Dec;38(12):2527-2536, doi: 10.1097/HJH.0000000000002582. PMID: 32740404; PMCID: PMC8218338.
  • Ernst ME, Chowdhury EK, Beilin LJ, Margolis KL, Nelson MR, Wolfe R, Tonkin AM, Ryan J, Woods RL, McNeil JJ, Reid CR, for the ASPREE Investigator Group. Long-Term Blood Pressure Variability and Risk of Cardiovascular Disease Events Among Community-Dwelling Elderly. Hypertension, doi:10.1161/HYPERTENSIONAHA.120.16209 [published online 2020 Nov. 2].
  • Lockery JE, Ernst ME, Broder JC, Orchard SG, Murray A, Nelson MR, Stocks NP, Wolfe R, Reid CM, Liew D, Woods RL; ASPREE Investigator Group. Prescription Medication Use in Older Adults Without Major Cardiovascular Disease Enrolled in the Aspirin in Reducing Events in the Elderly (ASPREE) Clinical Trial. Pharmacotherapy 2020; Oct;40(10):1042-1053, doi:10.1002/phar.2461.
  • Robman LD, Thao LTP, Guymer RH, Wolfe R, Woods RL, Hodgson LAB, Phung J, Makeyeva GA, Le-Pham YA, Orchard SG, Suleiman J, Maguire E, Trevaks RE, Ward SA, Riaz M, Lacaze P, Elsdon S, Abhayaratna WP, Nelson MR, Ernst ME, Reid CM, McNeil JJ; ASPREE Investigator Group. Baseline characteristics and age-related macular degeneration in participants of the “ASPirin in Reducing Events in the Elderly” (ASPREE)-AMD trial. Contemporary Clinical Trials Communications 2020; 20: 100667,  doi:10.1016/jconctc.2020.100667 [published online 2020 Oct. 11].
  • Eisen DP, Leder K, Woods RL, Lockery JE, McGuinness SL, Wolfe R, Pilcher D, Moore EM, Shastry A, Nelson MR, Reid C, McNeil, JJ, McBryde ES. Effect of aspirin on deaths associated with sepsis in healthy older people (ANTISEPSIS): a randomised, double-blind, placebo-controlled primary prevention trial. The Lancet Respiratory Medicine 2020, doi.org/10.1016/S2213-2600(20)30411-2 [published online 2020 Sept. 17].
  • Gilmartin-Thomas JFM, Ernst ME, Nelson MR, Lockery JE, Ward SA, Woods RL, Britt C, Murray A, Workman B, McNeil JJ; ASPREE Investigator Group. Musculoskeletal Pain Experienced on Most Days is a Common Accompaniment of Ageing amongst Community-Dwelling Older Australians: A Questionnaire-Based Study. Journal of Aging and Health 2020, doi:10.1177/0898264320952914 [pre-print published online 2020 Sept. 11].
  • Wolfe R, Wetmore JB, Wood RL, McNeil JJ, Gallagher H, Roderick P, Walker R, Nelson MR, Reid CM, Shah RC, Ernst ME, Lockery JE, Tonkin AM, Abhayaratna WP, Gibbs P, Wood EM, Mahady SE, Williamson JD, Donnan GA, Cloud GC, Murray AM, Polkinghorne K, for the ASPREE Investigator Group. Subgroup analysis of the ASPirin in Reducing Events in the Elderly randomized clinical trial suggest aspirin did not improve outcomes in older adults with chronic kidney disease. Kidney International 2020, doi.org/10.1016/j.kint.2020.08.011  [published online 2020 Sept. 10].
  • Gilmartin-Thomas JFM, Cicuttini FM, Owen AJ, Wolfe R, Ernst ME, Nelson MR, Lockery J, Woods RL, Britt C, Liew D, Murray A, Workman B, Ward SA, McNeil JJ; ASPREE Investigator Group. Moderate or severe low back pain is associated with body mass index amongst community-dwelling older Australians. Arch Gerontol & Geriatrics 91; Nov-Dec 2020, 104231, doi:10.1016/j.archger.2020.104231 [published online 2020 Aug. 13].
  • McNeil JJ, Gibbs P, Orchard SG, Lockery JE, Bernstein WB, Cao Y, Ford L, Haydon A, Kirpach B, Macrae F, McLean C, Millar J, Murray AM, Nelson MR, Polekhina G, Reid CM, Richmond E, Rodríguez LM, Shah RC, Tie J, Umar A, van Londen GJ, Ronaldson K, Wolfe R, Woods RL, Zalcberg J, Chan A, for the ASPREE investigator Group. Effect of aspirin on cancer incidence and mortality in older adults. JNCI: Journal of the National Cancer Institute, djaa114, doi.org/10.1093/jnci/djaa114 [accepted manuscript published online 2020 Aug. 11].
  • Ryan J, Woods RL, Britt CJ, Murray AM, Shah RC, Reid CM, Wolfe R, Nelson MR, Orchard SG, Lockery JE, Trevaks RE, Storey E, for the ASPREE Investigator Group. Normative Data for the Symbol Digit Modalities Test in Older White Australians and Americans, African-Americans, and Hispanic/Latinos. J Alzheimer’s Disease Reports 2020;4: 313-23, doi: 10.3233/ADR-200194. [published online 2020 Aug. 04].
  • Mahady SE, Margolis KL, Chan A, Polekhina G, Woods RL, Wolfe R, Nelson MR, Lockery JE, Wood EM, Reid C, Ernst ME, Murray A, Thao LTP, McNeil JJ. Major GI bleeding in older persons using aspirin: incidence and risk factors in the ASPREE randomised controlled trial. Gut 2020, doi:10.1136/gutjnl-2020-321585 [published online 2020 Aug. 03].
  • Orchard SG, Lockery JE, Gibbs P, Polekhina G, Wolfe R, Zalcberg J, Haydon A, McNeil JJ, Nelson MR, Reid CM, Kirpach B, Murray AM, Woods RL, for the ASPREE investigator Group. Cancer history and risk factors in healthy older people enrolling in the ASPREE clinical trial. Contemporary Clinical Trials 2020; Sept. doi.org/10.1016/j.cct.2020.106095 [published online 2020 July 31].
  • Orchard ER, Ward PGD, Sforazzini F, Storey E, Egan G, Jamadar SD. Relationship between parenthood and cortical thickness in late adulthood. PLoS One 2020; 15(7):e0236031, doi:10.1371/journal.pone.0236031 [published online 2020 July 28].
  • Ward PDG, Orchard ER, Oldham S, Arnatkevičiūtė A, Sforazzini F, Fornito A, Storey E, Egan G, Jamadar SD. Individual differences in haemoglobin concentration influence bold fMRI functional connectivity and its correlation with cognition. NeuroImage 2020; 221:117196, doi:10.1016/j.neuroimage.2020.117196 [published online ahead of print 2020 July 25].
  • Ernst ME, Chowdhury EK, Nelson MR, Reid CM, Margolis KL, Beilin LJ, Stocks N, Murray AM, Wolfe R, Lockery JE, Orchard SG, Woods RL, McNeil JJ; the ASPREE Investigator Group. Antihypertensive medications use and blood pressure control among treated older adults. J Clin Hypertens. 2020; 00: 1– 9, doi.org/10.1111/jch.13934 [published online 2020 July 15].
  • Fransquet PD, Lacaze P. Saffery R, Phung J, Parker E, Shah R, Murray A, Woods RL, Ryan J. Blood DNA methylation signatures to detect dementia prior to overt clinical symptoms. Alzheimer’s & Dementia 2020; 12:e12056,  doi: 10.1002/dad2.12056 [published online 2020 July 7].
  • Davis SR, Garcia AM, Robinson PJ, Handelsman DJ, Desai R, Wolfe R, Bell RJ, the ASPREE Investigator Group, Estrone is a strong predictor of circulating estradiol in women aged 70 years and older, The Journal of Clinical Endocrinology & Metabolism, 2020; dgaa429, doi.org/10.1210/clinem/dgaa429 [accepted manuscript 2020 July 02].
  • Lacaze P, Sebra R, Riaz M, Tiller J, Revote J, Phung J, Parker EJ, Orchard SG, Lockery JE, Wolfe R, Strahl M, Wang YC, Chen R, Sisco D, Arnold T, Thompson BA, Buchanan DD, Macrae FA, James PA, Abhayaratna WP, Lockett TJ, Gibbs P, Tonkin AM, Nelson MR, Reid CM, Woods RL, Murray AM, Winship I, McNeil JJ, Schadt E. Medically actionable pathogenic variants in a population of 13,131 healthy elderly individuals. Genet Med. 2020; Nov;22(11):1883-1886, doi: 10.1038/s41436-020-0881-7 [epub 2020 July 1]. PMID: 32606442; PMCID: PMC7606791
  • Zhou Z, Ofori-Asenso R, Curtis A, Breslin M, Wolfe R, McNeil JJ, Murray AM, Ernst ME, Reid CM, Lockery JE, Woods RL, Tonkin AM, Nelson MR. Association of Statin Use with Disability-Free Survival and Cardiovascular Disease among Healthy Older Adults. J Amer Coll Cardiol. 2020; June 30; 76: 17-27, doi:10.1016/j.jacc.2020.05.016.
  • Lewis JP, Riaz M, Xie S, Polekhina G, Wolfe R, Nelson M, Tonkin AM, Reid CM, Murray AM, McNeil JJ, Shuldiner AR, Lacaze P. Genetic variation in PEAR1, cardiovascular outcomes and effects of aspirin in a healthy elderly population. Clin Pharmacol Ther. 2020, doi: 10.1002/cpt.1959 [online ahead of print 2020 June 20]. PMID: 32562573
  • Lacaze P, Sebra R, Riaz M, Hooper AJ, Tiller J, Bakshi A, Woods RL, Tonkin AM, Reid CM, Murray AM, Nicholls SJ, Watts GF, Schadt E, McNeil JJ. Familial Hypercholesterolemia in a Healthy Elderly Population. Circ Genom Precis Med. 2020; June 10, doi:10.1161/CIRCGEN.120.002938 [epub ahead of print].
  • Berk M, Woods RL, Nelson MR, Shah RC, Reid CM, Storey E, Fitzgerald S, Lockery JE, Wolfe, R, Mohebbi M, Dodd S, Murray AM, Stocks N, Fitzgerald P, Mazza C, Agustini B, McNeil JJ.  Effect of Aspirin vs Placebo on the Prevention of Depression in Older People: A Randomized Clinical Trial. JAMA Psychiatry 2020, doi:10.1001/jamapsychiatry.2020.1214 [published online 2020 June 03].
  • Agustini B, Lotfaliany M, Woods RL, McNeil JJ, Nelson MR, Shah RC, Murray AM, Ernst M, Reid CM, Tonkin A, Storey E, Lockery JE, Williams LJ, Berk M, Mohebbi M, on behalf of the ASPREE investigators. Patterns of association between depressive symptoms and chronic medical morbidities in older adults. J Amer Geriatrics Soc. 2020, doi 10.1111/jgs.16468. [published online 2020 May 13].
  • Woods RL, Polekhina G, Wolfe R, Nelson MR, Ernst ME, Reid CM, Shah RC, Lockery JE, Orchard SG, Murray AM, McNeil JJ, on behalf of the ASPREE Investigator Group. No modulation of aspirin’s effect by body weight in healthy older men and women. Circulation 2020; Mar. 30, doi.org/10.1161/CIRCULATIONAHA.119.044142.
  • Ryan J, Storey E, Murray AM, Woods RL, Wolfe R, Reid CM, Nelson MR, Chong T, Williamson JD, Ward SA, Lockery JE, Orchard SG, Trevaks R, Kirpach B, Newman AB, Ernst ME, McNeil JJ, Shah RC. Randomized Placebo-controlled Trial of the effects of Aspirin on Dementia and Cognitive Decline. Neurology 2020; Mar. 25, doi.org/10.1212/WNL.0000000000009277.
  • Barker AL, Soh SE, Sanders KM, Pasco J, Khosla S, Ebeling PR, Ward SA, Peeters G, Talevski J, Cumming RG, Seeman E, McNeil JJ. Aspirin and fracture risk: a systematic review and exploratory meta-analysis of observational studies. BMJ Open 2020; Feb. 20;10(2):e026876, doi: 10.1136/bmjopen-2018-026876.
  • Ryan J, Woods RL, Murray AM, Shah RC, Britt C, Reid CM, Wolfe R, Nelson MR, Lockery JE, Orchard SG, Trevaks R, Chong T, McNeil JJ, Storey E.  Normative Performance of Older Individuals on the Hopkins Verbal Learning Test-Revised (HVLT-R) According to Ethno-Racial Group, Gender, Age and Education Level. The Clinical Neuropsychologist 2020; Feb. 26, doi:10.1080/13854046.2020.1730444.
  • Agustini B, Mohebbi M, Woods RL, McNeil JJ, Nelson MR, Shah RC, Murray AM, Ernst ME, Reid CM, Tonkin A, Lockery JE, Berk M, on behalf of the ASPREE Investigator Group. The association of antihypertensive use and depressive symptoms in a large older population with hypertension living in Australia and the United States. Journal of Human Hypertension 2020; Pubmed 32001828,  doi.org/10.1038/s41371-020-0303-y.
  • Pinese M, Lacaze P, Rath E, Stone A, Brion MJ, Ameur A, Nagpal S, Puttick C, Husson S, Degrave D, Navin Cristina T, Kahl VS, Statham A, Woods R, McNeil J, Riaz M, Barr M, Nelson M, Reid C, Murray A, Shah R, Wolfe R, Atkins J, Fitzsimmons C, Cairns H, Green M, Carr V, Cowley M, Pickett H, James P, Powell J, Kaplan W, Gibson G, Gyllensten U, Cairns M, McNamara M, Dinger M, Thomas D. The Medical Genome Reference Bank contains whole genome and phenotype data of 2,570 healthy elderly. Nature Communications Online 2020; Jan. 23, doi:10.1038/s41467-019-14079-0.
  • Voskoboinik I, Lacaze P, Jang HS, Flinsenberg TWH, Fernando SL, Kerridge I, Riaz M, Sebra R, Thia KYT, Noori T, Schadt EE, McNeil JJ, Trapani JA. Prevalence and Disease Predisposition of p.A91V perforin in an aged Caucasian Population. Blood Journal 2020, doi:10.1182/blood-2019003487 [epub ahead of print 2020 Jan. 13].

2019

  • Lockery JE, Rigby J, Collyer TA, Stewart A, Woods RL, McNeil JJ, Reid CM, Ernst ME, on behalf of the ASPREE Investigator Group. Optimising medications data collection in a large-scale clinical trial. Plos One  2019; 14 (12), doi.org/10.1371/journal.pone.0226868.
  • Chowdhury EK, Nelson MR, Ernst ME, Margolis KL, Beilin LJ, Johnston CI, Woods RL, Murray AM, Wolfe R, Storey E, Shah RC, Lockery JE, Tonkin AM, Newman AB, Williamson JD, Abhayaratna WP, Stocks NP, Fitzgerald SM, Orchard SG, Trevaks RE, Donnan GA, Grimm R, McNeil JJ, Reid CM, for the ASPREE investigator Group. Factors associated with treatment and control of hypertension in a healthy elderly population free of cardiovascular disease: a cross-sectional study. American Journal of Hypertension 2019; Dec. 06, doi.org/10.1093/ajh/hpz192.
  • Jamadar SD, Sforazzini F, Raniga P, Ferris NJ, Paton B, Bailey MJ, Brodtmann A, Yates PA, Donnan GA, Ward SA, Woods RL, Storey E, McNeil JJ, Egan GF;  ASPREE Investigator Group. Sexual Dimorphism of Resting-State Network Connectivity in Healthy Ageing. The journals of gerontology. Series B, Psychological sciences and social sciences 2019; 74 (7): 1121-1131, doi:10.1093/geronb/gby004.
  • Lockery JE, Collyer TA, Reid CM, Ernst ME, Gilbertson D, Hay N, Kirpach B, McNeil JJ, Nelson MR, Orchard SG, Pruksawongsin K, Shah RC, Wolfe R, Woods RL, on behalf of the ASPREE Investigator Group. Overcoming challenges to data quality in the ASPREE clinical trial. Trials 2019; 20: 686, doi:10.1186/s13063-019-3789-2.
  • Davis SR, Bell RJ, Robinson PJ, Handelsman DJ, Gilbert T, Phung J, Desai R, Lockery JE, Woods RL, Wolfe RS, Reid CM, Nelson  MR, Murray AM, McNeil JJ. Testosterone and estrone increase from the age of 70 years; findings from the Sex Hormones in Older Women Study. J Clinical Endocrinology & Metabolism 2019; Aug. 13; pii: jc.2019-00743, doi: 10.1210/jc.2019-00743 [epub ahead of print].
  • Agustini B, Mohebbi M, Woods RL, McNeil JJ, Nelson MR, Shah RC, Murray AM, Ernst ME, Reid CM, Tonkin A, Lockery JE, Berk M; ASPREE Investigator Group. Association Between Statin Use and Depressive Symptoms in a Large Community-Dwelling Older Population Living in Australia and the USA: A Cross-Sectional Study. CNS Drugs 2019; May 6, doi: 10.1007/s40263-019-00633-3 [epub ahead of print].
  • Polkinghorne KR, Wolfe R, Jachno KM, Wetmore JB, Woods RL, McNeil JJ, Nelson MR, Reid CM, Murray AM; ASPREE Investigator Group. Prevalence of chronic kidney disease in the elderly using the ASPirin in Reducing Events in the Elderly study cohort. Nephrology 2019; 24:1248-1256, doi: 10.1111/nep.13565.
  • Mohebbi M, Agustini B, Woods RL, McNeil JJ, Nelson MR, Shah RC, Nguyen V, Storey E, Murray AM, Reid CM, Kirpach B, Wolfe RS, Lockery JE, Berk M; ASPREE Investigator Group. Prevalence of depressive symptoms and its associated factors among healthy community-dwelling older adults living in Australia and the United States. Int J Geriatr Psychiatry 2019; Apr. 16, doi: 10.1002/gps.5119 [epub ahead of print].
  • Lockery JE, Collyer TA, Abhayaratna WP, Fitzgerald SM, McNeil JJ, Nelson MR, Orchard SG, Reid C, Stocks NP, Trevaks RE, Woods RL. Recruiting general practice patients for large clinical trials: lessons from the Aspirin in Reducing Events in the Elderly (ASPREE) study. Med J Aust 2019; 210 (4): 168-173, doi: 10.5694/mja2.12060.
  • CORRESPONDENCE McNeil JJ, Woods RL, Murray AM, for the ASPREE Investigator Group. Effects of aspirin in the healthy elderly. Correspondence. N Engl J Med 2019; 380 (18): 1776-7, doi:10.1056/NEJMc1901774.
  • COMMENTARY Chan AT, McNeil J. Aspirin and Cancer Prevention in the Elderly: Where Do We Go From Here? Gastroenterology. 2019 Feb; 156(3):534-538, doi: 10.1053/j.gastro.2018.11.063.
  • McNeil JJ, Woods RL, Ward SA, Britt CJ, Lockery JE, Beilin LJ, Owen AJ. Cohort Profile: The ASPREE Longitudinal Study of Older Persons (ALSOP). International Journal of Epidemiology 2019, doi.org/10.1093/ije/dyy279.

2018

  • Lacaze P, Pinese M, Kaplan W, Stone A, Brion M, Woods RL, McNamara M, McNeil JJ, Dinger ME, Thomas DM. The Medical Genome Reference Bank: a whole-genome data resource of 4,000 healthy elderly individuals. Rationale and cohort design. European Journal of Human Genetics 2018, doi: 10.1038/s41431-018-0279-z.
  • Stocks N, González-Chica DA, Lockery JE, Shah RC, Murray AM, Wolfe R, Nelson MR, Reid CM, McNeil JJ, Woods RL, on behalf of the ASPREE Investigator Group. Quality of Life for 19,114 participants in the ASPREE (Aspirin in Reducing Events in the Elderly) Study and their association with sociodemographic and lifestyle modifiable risk factors. Quality of Life Research 2018, pp.1-12, doi: 10.1007/s11136-018-2040-z.
  • McNeil JJ*, Woods RL*, Nelson MR, Reid CM, Kirpach B, Wolfe R, Storey E, Shah RC, Lockery JE, Tonkin AM, Newman AB, Williamson JD, Margolis KL, Ernst ME, Abhayaratna WP, Stocks N, Fitzgerald SM, Orchard SG, Trevaks RE, Beilin LJ, Donnan GA, Gibbs P, Johnston CI, Ryan J, Radziszewska B, Grimm R & Murray AM, on behalf of the ASPREE Investigator Group (* joint first authors). Effect of aspirin on disability-free survival in the healthy elderly. New England Journal of Medicine 2018; 379:1499-1508, doi: 10.1056/nejmoa1800722 [published online Sept. 2018].
  • McNeil JJ*, Nelson MR*, Woods RL, Lockery JE, Wolfe R, Reid CM, Kirpach B, Shah RC, Ives DG, Storey E, Ryan J, Tonkin AM, Newman AB, Williamson JD, Margolis KL, Ernst ME, Abhayaratna WP, Stocks N, Fitzgerald SM, Orchard SG, Trevaks RE, Beilin LJ, Donnan GA, Gibbs P, Johnston CI, Radziszewska B, Grimm R & Murray AM, on behalf of the ASPREE Investigator Group (* joint first authors). Effect of aspirin on all-cause mortality in the healthy elderly. New England Journal of Medicine 2018; 379:1499-1508, doi: 10.1056/NEJMoa1803955 [published online Sept. 2018].
  • McNeil JJ, Wolfe R, Woods RL, Tonkin AM, Donnan GA, Nelson MR, Reid CM, Lockery JE, Kirpach B, Storey E, Shah RC, Williamson JD, Margolis KL, Ernst ME, Abhayaratna WP, Stocks N, Fitzgerald SM, Orchard SG, Trevaks RE, Beilin LJ, Johnston CI, Ryan J, Radziszewska B, Jelinek M, Malik M, Eaton C, Brauer D, Cloud G, Wood E, Mahady SE, Satterfield S, Grimm R & Murray AM, on behalf of the ASPREE Investigator Group. Effect of aspirin on cardiovascular events and bleeding in the healthy elderly. New England Journal of Medicine 2018; 379:1499-1508, doi: 10.1056/nejmoa1805819 [published online Sept. 2018].
  • Ryan J, Woods RL, Britt C, Murray AM, Shah RC, Reid CM, Kirpach B, Wolfe RS, Nelson MR, Lockery JE, Orchard SG, Trevaks RE, McNeil JJ, Storey E, on behalf of the ASPREE Investigator Group. Normative performance of healthy older individuals on the Modified Mini-Mental State (3MS) examination according to ethno-racial group, gender, age, and education level. The Clinical Neuropsychologist 2018, doi.org/10.1080/13854046.2018.1488996 [published online July 2018].
  • Margolis KL, Mahady SE, Nelson MR, Ives DG, Satterfield S, Britt C, Ekram S, Lockery JE, Schwartz EC, Woods RL, McNeil JJ, Wood EM. Development of a standardized definition for clinically significant bleeding in the ASPirin in Reducing Events in the Elderly (ASPREE) trial. Contemporary Clinical Trials Communications 2018; Vol 11, 30-36, doi.org/10.1016/j.conctc.2018.05.015.
  • Wolfe R, Murray AM, Woods, RL, Kirpach B, Gilbertson D, Shah RC, Nelson MR, Reid CM, Ernst ME, Lockery JE, Donnan GA, Williamson J, McNeil JJ. The aspirin in reducing events in the elderly trial: Statistical analysis plan. International Journal of Stroke 2018; Vol.13(3), pp.335-338, doi.org/10.1177/1747493017741383.
  • Fransquet PD, Lacaze P, Woods RL, McNeil JJ, Saffery R, Ryan J. Blood DNA methylation as a potential biomarker of dementia: a systematic review. Alzheimer’s & Dementia 2017; 14(1): 81-103. IF:11.0, doi: 10.1016/j.jalz.2017.10.002.
  • Ward SA, Storey E, Woods RL, Hamilton GS, Kawasaki R, Janke AL, Naughton MT, O’Donoghue F, Wolfe R, Wong TY, Reid CM, Abhayaratna WP, Stocks N, Trevaks R, Fitzgerald S, Hodgson LAB, Robman L, Workman B, Mcneil JJ. The Study of Neurocognitive Outcomes, Radiological and Retinal Effects of Aspirin in Sleep Apnoea- rationale and methodology of the SNORE-ASA study. Contemporary clinical trials 2018; Vol.64, pp.101-111, doi.org/10.1016/j.cct.2017.10.016.
  • Mohebbi M, Nguyen V, McNeil JJ, Woods RL, Nelson MR, Shah RC, Storey E, Murray AM, Reid CM, Kirpach B, Wolfe, R, Lockery JE, Berk M, on behalf of the ASPREE investigator group. Psychometric properties of a short form of the Center for Epidemiologic Studies Depression (CES-D-10) scale for screening depressive symptoms in healthy community dwelling older adults. General Hospital Psychiatry 2018; 51:118-125, doi: 10.1016/j.genhosppsych.2017.08.002.

2017-2015

  • McNeil JJ, Woods RL, Nelson MR, Murray AM, Reid CM, Kirpach B, Storey E, Shah RC, Wolfe R, Tonkin AM, Newman AB, Williamson JD, Lockery JE, Margolis KL, Ernst ME, Abhayaratna WP, Stocks N, Fitzgerald SM, Trevaks RE, Orchard SG, Beilin LJ, Donnan GA, Gibbs P, Johnston CI, Grimm RH, on behalf of the ASPREE investigator group. Baseline Characteristics of Participants in the ASPREE (ASPirin in Reducing Events in the Elderly) Study. J Gerontol A Biol Sci Med Sci 2017; Oct 12, Vol. 00, No. 00, 1–8, doi:10.1093/gerona/glw342.
  • Ward SA, Raniga P, Ferris NJ, Woods RL, Storey E, Bailey MJ, Brodtmann A, Yates PA, Donnan GA, Trevaks RE, Wolfe R, Egan GF, McNeil JJ; (Joint Senior authorship), on behalf of the ASPREE investigator group. ASPREE-NEURO study protocol: A randomized controlled trial to determine the effect of low-dose aspirin on cerebral microbleeds, white matter hyperintensities, cognition, and stroke in the healthy elderly. Int J Stroke 2017; 12(1):108-113, doi:10.1177/1747493016669848.
  • Lacaze P, Winship I, McNeil J. Penetrance and the Healthy Elderly. Genet Test Mol Biomarkers 2017; Nov 21(11):637-640, doi: 10.1089/gtmb.2017.0126 [epub 2017 Sept. 6].
  • Robman L, Guymer R, Woods RL, Ward SA, Wolfe R, Phung J, Hodgson L, Makeyeva G, Aung KZ, Gilbert T, Lockery JE, Le-Pham Y, Orchard S, Storey E, Abhayaratna W, Reid D, Ernst ME, Nelson MR, Reid C, McNeil, JJ. Age-related macular degeneration in a randomized controlled trial of low-dose aspirin: Rationale and study design of the ASPREE-AMD study. Contemporary Clinical Trials Communications 2017; Vol.6, pp.105-114, doi:10.1016/j.conctc.2017.03.005.
  • Lacaze P, Ryan J, Woods RL, Winship I, McNeil JJ. Pathogenic variants in the healthy elderly: unique ethical and practical challenges. Journal of Medical Ethics, 2017; Vol. 43(10), p.714, doi: 10.1136/medethics-2016-103967.
  • Lacaze P, Woods RL, Zoungas S, McNeil JJ. The genomic potential of the Aspirin in Reducing Events in the Elderly and Statins in Reducing Events in the Elderly studies. Internal medicine Journal 2017; Vol.47(4), pp.461-463, doi.org/10.1111/imj.13384.
  • Eisen DP, Moore EM, Leder K, Lockery JE, McBryde ES, McNeil JJ, Pilcher D, Wolfe R, Woods RL. AspiriN To Inhibit SEPSIS (ANTISEPSIS) randomised controlled trial protocol. BMJ Open 2017;7:e013636, doi: 10.1136/bmjopen-2016-013636.
  • Berk M, Woods RL, Nelson MR, Shah RC, Reid CM, Storey E, Fitzgerald SM, Lockery JE, Wolfe R, Mohebbi M, Murray AM, Kirpach B, Grimm R, McNeil JJ. ASPREE-D: Aspirin for the prevention of depression in the elderly. International Psychogeriatrics 2016, doi:10.1017/S104161021600079X.
  • Lowthian JA, Britt CJ, Rance G, Lin FR, Woods RL, Wolfe R, Nelson MR, Dillon HA, Ward S, Reid CM, Lockery JE, Nguyen TT, McNeil JJ, Storey E. Slowing the progression of age-related hearing loss: Rationale and study design of the ASPIRIN in HEARING, retinal vessels imaging and neurocognition in older generations (ASPREE-HEARING) trial. Contemp Clin Trials 2015; 46; 60-66, doi: 10.1016/j.cct.2015.11.014.
  • Barker AL, McNeil JJ, Seeman E, Ward SA, Sanders KM, Khosla S, Cumming RG, Pasco JA, Bohensky MA, Ebeling PR, Woods RL, Lockery JE, Wolfe R, Talevski J, and the ASPREE Investigator Group. A randomised controlled trial of low-dose aspirin for the prevention of fractures in healthy older people: protocol for the ASPREE-Fracture substudy. Inj Prev. 2015; pii: injuryprev-2015-041655, doi: 10.1136/injuryprev-2015-041655 [epub ahead of print]. PMID: 26002770

2014-2010

  • COMMENTARY Chong EW, Guymer RH, Robman LD. Does aspirin increase the risk of age-related macular degeneration? Expert Opinion on Drug Safety 2014; 13:691-3, doi: 10.1517/14740338.2014.914169.
  • ASPREE Investigator Group. Study design of ASPirin in Reducing Events in the Elderly (ASPREE): a randomized, controlled trial. Contemporary Clinical Trials 2013; 36: 555–564, doi: org/10.1016%2Fj.cct.2013.09.014.
  • COMMENTARY Nelson MR. General practice-based clinical trials. Perspectives, Med J Aust 2013; 198 (3), doi: 10.5694/mja12.11061.
  • Reid CM, Storey E, Wong TY, Woods RL, Tonkin A, Wang JJ, Kam A, Janke A, Essex R, Abhayaratna WP, Budge MM, on behalf of the ASPREE Study Group. Aspirin for the prevention of cognitive decline in the elderly: rationale and design of a neuro-vascular imaging study (ENVIS-ion). BMC Neurol. 2012; 12:3, doi: 10.1186/1471-2377-12-3.
  • Linden MD, Tran HA, Woods RL, Tonkin AM. High platelet reactivity and antiplatelet therapy resistance. Seminars in Thrombosis and Hemostasis 2012; 38(2):200-12, doi: 10.1055/s-0032-1301417.
  • Ward SA, Demos L, Workman B, McNeil JJ. Aspirin for primary prevention of cardiovascular events in the elderly: current status and future directions. Drugs Aging 2012; Apr. 1;29(4):251-8, doi.org/10.2165/11599030-000000000-00000.

2009-1990

  • EDITORIAL Woods RL, Tonkin AM, Nelson MR, Britt HC, Reid CM. Should aspirin be used for the primary prevention of cardiovascular disease in people with diabetes? Med J Aust. 2009; 190:614-5 PMID:19485837
  • Nelson MR, Reid CM, Ames DA, Beilin LJ, Donnan GA, Gibbs P, Johnston CI, Krum H, Storey E, Tonkin A, Wolfe R, Woods R, McNeil JJ. Feasibility of conducting a primary prevention trial of low-dose aspirin for major adverse cardiovascular events in older people in Australia: results from the ASPirin in Reducing Events in the Elderly (ASPREE) pilot study. Med J Aust. 2008; 189:105-109, doi.org/10.5694/j.1326-5377.2008.tb01932.x.  PMID:18637782
  • Nelson MR, Liew D, Bertram M, Vos T. Epidemiological modelling of routine use of low-dose aspirin in Australia for the primary prevention of coronary heart disease and stroke in those aged 70 years and above. BMJ 2005; 330:1306-1308, doi: 10.1136/bmj.38456.676806.8F.
  • CONFERENCE PROCEEDINGS Nelson MR, Reid CM, Johnstone CI, Krum H, Storey E, Tonkin A, Beilin LJ, Donnan GA, McNeil JJ.  After ANBP2 – ASPREE  Clinical And Experimental Pharmacology And Physiology, Melbourne, Australia 2003; Vol.30(7), pp.A59-A59.
  • ASPREE Study Group. Nelson MR, Reid CM, Beilin LJ, Donnan GA, Johnston CI, Krum H, Storey E, Tonkin AM, McNeil JJ.  Rationale for a primary prevention trial in the elderly of low dose aspirin for the prevention of major adverse cardiovascular events and vascular dementia in Australian general practice.  ASPirin in Reducing Events in the Elderly (ASPREE). J Drugs and Aging 2003; 20(12):897-903, doi: 10.2165/00002512-200320120-00004.
  • Silagy CA, McNeil JJ, Donnan GA, Tonkin AM, Worsam B, Campion K. The PACE pilot study: 12-month results and implications for future primary prevention trials in the elderly. (Prevention with low-dose Aspirin of Cardiovascular disease in the Elderly). J Am Geriatr Soc. 1994; 42(6):643-64, doi.org/10.1111/j.1532-5415.1994.tb06864.x.
  • Silagy CA, McNeil JJ, Donnan GA, Tonkin AM, Worsam B, Campion K. Adverse effects of low-dose aspirin in a healthy elderly population. Clin Pharmacol Ther, 1993; 54(1):84-89, doi:10.1038/clpt.1993.115.
  • Silagy CA, McNeil JJ, Bulpitt CJ, Donnan GA, Tonkin AM, Worsam B. Rationale for a primary prevention study using low-dose aspirin to prevent coronary and cerebrovascular disease in the elderly. J Am Geriatr Soc. 1991; 39(5):484-491, doi.org/10.1111/j.1532-5415.1991.tb02494.x.
  • Campion K, Silagy CA, McNeil JJ, Donnan GA, Tonkin AM, Worsam B. Comparison of recruitment strategies for a large-scale multicentred clinical trial in the elderly. Community Health Stud, 1990; 14(4):400, doi: 10.1016/0895-4356(91)90013-y.
Publications