PUBLICATIONS

Health related data collected in the ASPREE project continues to make important scientific contributions to improve the health of older adults today and in the future.

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Publication Key words
Lacaze P, Bakshi A, Riaz M, Orchard SG, Tiller J, Neumann JT, Carr PR, Joshi AD, Cao Y, Warner ET, Manning A, Nguyen-Dumont T, Southey MC, Milne RL, Ford L, Sebra R, Schadt E, Gately L, Gibbs P, Thompson BA, Macrae FA, James P, Winship I, McLean C, Zalcberg JR, Woods RL, Chan AT, Murray AM, McNeil JJ. Genomic Risk Prediction for Breast Cancer in Older Women. Cancers. 2021 July 14; 13(14):3533, doi.org/10.3390/cancers13143533 genetics, genomic, genome, carriers, polygenic, risk prediction, PRS, genotyping, variant, DNA, genetic testing, breast cancer, biobank, sub-study, substudy
Hu J, Fitzgerald SM, Owen AJ, Ryan J, Joyce J, Chowdhury E, Reid CM, Britt C, Woods RL, McNeil JJ, Freak-Poli R. Social isolation, social support, loneliness and cardiovascular disease risk factors: a cross-sectional study among older adults. Int J Geriatr Psychiatry. 2021 July 7 doi: /10.1002/gps.5601 CVD, cardiovascular, cardiac, risk factors, Framingham Risk Scale, ASCVDRS, social, health, isolation, support, loneliness, CES-D, CES-D-10, CESD, depressive symptoms, ALSOP, sub-study, substudy
Phyo AZZ, Ryan J, Gonzalez-Chica DA, Stocks NP, Reid CM, Tonkin AM, Woods RL, Nelson MR, Murray AM, Gasevic D, Freak-Poli R. Health-related quality of life and incident cardiovascular disease events in community-dwelling older people: A prospective cohort study. International Journal of Cardiology, 2021, doi: /10.1016/j.ijcard.2021.07.004 [published online, 2021 July 7]. quality, health, physical, QOL, SF-12, HRQol, CVD, cardiac, cardiovascular
Chowdhury EK, Ernst ME, Nelson M, Margolis K, Beilin LJ, Johnston C, Woods R, Murray A, Wolfe R, Storey E, Shah RC, Lockery J, Tonkin A, Newman A, Abhayaratna W, Stocks N, Fitzgerald S, Orchard S, Trevaks R, Donnan G, Grimm R, McNeil J, Reid CM; ASPREE Investigator Group. Impact of the 2017 American Heart Association and American College of Cardiology hypertension guideline in aged individuals. J Hypertens. 2020 Dec;38(12):2527-2536doi: 10.1097/HJH.0000000000002582. PMID: 32740404; PMCID: PMC8218338 blood pressure, hypertension, CVD, cardiac, cardiovascular, medications, guidelines
Lacaze P, Sebra R, Riaz M, Ingles J, Tiller J, Thompson BA, James PA, Fatkin D, Semsarian C, Reid CM, Tonkin AM, Winship I, Schadt E, McNeil JJ. Genetic variants associated with inherited cardiovascular disorders among 13,131 asymptomatic older adults of European descent. NPJ Genom Med. 2021 Jun 16;6(1):51, doi: 10.1038/s41525-021-00211-x. PMID: 34135346; PMCID: PMC8209162 genetics, genomic, genome, carriers, inherited, familial, genotyping, variant, DNA, genetic testing, risk, CVD, cardiac, cardiovascular, long-QT syndrome, SCD, biobank, sub-study, substudy
Zhou Z, Ryan J, Ernst ME, Zoungas S, Tonkin AM, Woods RL, McNeil JJ, Reid CM, Curtis AJ, Wolfe R, Wrigglesworth J, Shah RC, Storey E, Murray A, Orchard SG, Nelson MR. Effect of statin therapy on cognitive decline and incident dementia in older adults. J Am Coll Cardiol 2021 June 29, 77(25): 3145-56, doi:10.1016/j.jacc.2021.04.075. statins, medications, prescriptions, pharmacy, dementia, cognitive, cognition, neurological, cognitive decline, Alzheimers disease, Alzheimer's, 3MS, 3ms, memory
Ernst ME, Ryan J, Chowdhury EK, Margolis KL, Beilin LJ, Reid CM, Nelson MR, Woods RL, Shah RC, Orchard SG, Wolfe R, Storey E, Tonkin AM, Brodtmann A, McNeil JJ, Murray AM. Long-Term Blood Pressure Variability and Risk of Cognitive Decline and Dementia Among Older Adults. J Am Heart Assoc 2021, June 26; 10:e019613, doi:10.1161/JAHA.120.019613. blood pressure, hypertension, CVD, cardiac, cardiovascular, medications, BPV, blood pressure variability, dementia, cognitive, cognition, neurological, cognitive decline, Alzheimers disease, Alzheimer's, 3MS, 3ms, memory, COWAT, HVLT-R, SDMT
Neumann JT, Riaz M, Bakshi A, Polekhina G, Thao LTP, Nelson MR, Woods RL, Abraham G, Inouye M, Reid CM, Tonkin AM, Williamson JD, Donnan G, Brodtmann A, Cloud GC, McNeil JJ, Lacaze P. Predictive performance of a polygenic risk score for incident ischemic stroke in a healthy older population. Stroke 2021; 52, doi: 10.1161/STROKEAHA.120.033670. [epub ahead of print, May 27]. genetics, genomic, genome, carriers, polygenic, PRS, genotyping, variant, DNA, genetic testing, risk, ischaemic, stroke, CVA, cardiovascular, CVD, cardioembolic
Riaz M, Huq A, Ryan J, Orchard SG, Tiller J, Lockery J, Woods RL, Wolfe R, Renton AE, Goate AM, Sebra R, Schadt E, Brodtmann A, Shah RC, Storey E, Murray AM, McNeil JJ, Lacaze P. Effect of APOE and a polygenic risk score on incident dementia and cognitive decline in a healthy older population. Aging Cell. 2021, doi: 10.1111/acel.13384. [epub ahead of print, May 26]. PMID: 34041846 genetics, genomic, genome, carriers, polygenic, PRS, genotyping, variant, DNA, genetic testing, risk, APOE, dementia, cognitive, cognition, neurological, Alzheimers, cognitive decline, 3MS, 3ms, COWAT, HVLT-R, SDMT
Nunn JS, Sulovski M, Tiller J, Holloway B, Ayton D, Lacaze P. Involving elderly research participants in the co-design of a future multi-generational cohort study. Research Involvement and Engagement 2021 May 3, doi: org/10.1002/dad2.12180. participatory research, multigenerational, design, co-design, participants, consumers, familial, inherited
Wu Z, Woods RL, Wolfe R, Storey E, Chong TTJ, Shah RC, Orchard SG, McNeil JJ, Murray AM, Ryan J; the ASPREE Investigator Group. Trajectories of cognitive function in community‐dwelling older adults: A longitudinal study of population heterogeneity. Alzheimer’s Dement. 2021 May 2, doi: org/10.1002/dad2.12180. dementia, Alzheimers disease, Alzheimer's, cognition, cognitive, 3MS, 3ms, neurological, trajectory, memory, function, COWAT, HVLT‐R, SDMT, modelling
Bakshi A, Yan M, Riaz M, Polekhina G, Orchard SG, Tiller J, Wolfe R, Joshi A, Cao Y, McInerney-Leo AM, Yanes T, Janda M, Soyer HP, Cust AE, Law MH, Gibbs P, McLean C, Chan AT, McNeil JJ, Mar VJ, Lacaze P. Genomic Risk Score for Melanoma in a Prospective Study of Older Individuals. J Natl Cancer Inst. 2021, doi: 10.1093/jnci/djab076 [epub ahead of print, 2021 April 10]. PMID: 33837773 genetics, genomic, genome, carriers, polygenic, PRS, genotyping, variant, DNA, genetic testing, risk, melanoma, cancer, skin, biobank, sub-study, substudy
Lockery JE, Broder JC, Ryan J, Stewart AC, Woods RL, Chong TT, Cloud GC, Murray A, Rigby JD, Shah R, Storey E, Ward SA, Wolfe R, Reid CM, Collyer TA, Ernst ME; the ASPREE Investigator Group. A Cohort Study of Anticholinergic Medication Burden and Incident Dementia and Stroke in Older Adults. J Gen Intern Med. 2021, doi: 10.1007/s11606-020-06550-2 [published online, 2021 Mar. 22]. PMID: 33754317 anticholinergic, medications, prescriptions, pharmacy, stroke, CVA, dementia, cognitive decline, cognition, 3MS, 3ms
Phyo AZZ, Gonzalez-Chica DA, Stocks NP, Storey E, Woods RL, Murray AM, Orchard SG, Shah RC, Gasevic D, Freak-Poli R, Ryan J; ASPREE Investigator Group. The Utility of Assessing Health-Related Quality of Life to Predict Cognitive Decline and Dementia. J Alzheimers Dis. 2021,  doi: 10.3233/JAD-201349 [published online, 2021 Feb. 12]. PMID: 33579847 lifestyle, QOL, HRQoL, quality, health, mental, SF-12, mood, dementia, cognitive decline, cognition, 3MS
EDITORIAL McNeil JJ. Aspirin and primary prevention of colorectal cancer: a still evolving story. JNCI: Journal of the National Cancer Institute, 2021;djab010, doi:org/10.1093/jnci/djab010 [published online, 2021 Feb. 02]. aspirin, cancers, mortality, deaths, neoplasms, diagnosis, endpoints, end-points, end points, chemoprotective, incidence, CRC, metastasis, non-metastatic, metastatic 
Berk M, Agustini B, Woods RL, Nelson MR, Shah RC, Reid CM, Storey E, Fitzgerald S, Lockery JE, Wolfe R, Mohebbi M, Dodd S, Murray AM, Stocks N, Fitzgerald P, Mazza C, McNeil JJ. Effects of aspirin on the long-term management of depression in older people: a double-blind randomised placebo-controlled trial. Mol Psychiatry 2021, doi: org/10.1038/s41380-021-01020-5 [published online, 2021 Jan. 27]. aspirin, depression, CES-D, CES-D-10, CESD, depressive, cognitive, mood, mental, endpoints, end-points, end points, sub-study, substudy, prevention, psychiatry
Phyo A, Ryan J, Gonzalez-Chica DA, Woods RL, Reid CM, Nelson MR, Murray AM, Gasevic D, Stocks NP, Freak-Poli R; the ASPREE Investigator Group. Health-related quality of life and all-cause mortality among older health individuals in Australia and the United States: a prospective cohort study. Quality of Life Research 2021;30(4):1037-48. doi:10.1007/s11136-020-02723-y [published online, 2021 Jan. 03]. lifestyle, QOL, HRQoL, quality, health, mental, physical, SF-12, mood, mortality
Woods RL, Espinoza S, Thao LTP, Ernst ME, Ryan J, Wolfe R, Shah RC, Ward SA, Storey E, Nelson MR, Reid CM, Lockery JE, Orchard SG, Trevaks RE, Fitzgerald SM, Stocks NP, Williamson JD, McNeil JJ, Murray AM, Newman AB; ASPREE Investigator Group. Effect of Aspirin on Activities of Daily Living Disability in Community-Dwelling Older Adults. J Gerontol A Biol Sci Med Sci. 2020; glaa316, doi:10.1093/gerona/glaa316 [published online ahead of print, 2020 Dec. 26]. aspirin, physical function, ADLS, disability, prevention, functional, activities daily living
Islam RM, Bell RJ, Handelsman DJ, Robinson PJ, Wolfe R, Davis SR; ASPREE Investigator Group. Longitudinal changes over three years in sex steroid hormone levels in women aged 70 years and over. Clin Endocrinol (Oxf). 2020; Dec. 22, doi: 10.1111/cen.14401 [epub ahead of print]. PMID: 33351205 sex steroids, androgens, postmenopause, women, females, testosterone, blood, blood, levels, androgen, oestrogen, sex hormones, substudy, sub-study, biobank, steroids
Lefevre A, Hopper I, McNeil JJ, Owen A; ALSOP Complementary Medicine Research Group. Complementary medicine use by community-dwelling older Australians [published online ahead of print, 2020 Dec 10]. Med J Aust. 2020; 10.5694/mja2.50884, doi:10.5694/mja2.50884 [published online ahead of print, 2020 Dec. 9]. ALSOP, sub-study, substudy, longitudinal, questionnaires, complementary medicine, vitamins, supplements
Gilmartin-Thomas JF, Forbes A, Liew D, McNeil JJ, Cicuttini FM, Owen AJ, Ernst ME, Nelson MR, Lockery J, Ward SA, Busija L; ASPREE Investigator Group. Evaluation of the Pain Impact Index for community-dwelling older adults through the application of Rasch modelling. Pain Pract. 2020; Dec. 9, doi: 10.1111/papr.12980 [epub ahead of print]. PMID: 33295122 pain, knee, back, ALSOP, substudy, sub-study, questionnaires, Rasch analysis, psychometrics
Ernst ME, Chowdhury EK, Beilin LJ, Margolis KL, Nelson MR, Wolfe R, Tonkin AM, Ryan J, Woods RL, McNeil JJ, Reid CR, for the ASPREE Investigator Group. Long-Term Blood Pressure Variability and Risk of Cardiovascular Disease Events Among Community-Dwelling Elderly. Hypertension, doi:10.1161/HYPERTENSIONAHA.120.16209 [published online 2020 Nov. 2]. blood pressure, hypertension, CVD, cardiac, cardiovascular, BPV, blood pressure variability, medications, poly pharmacy, prescriptions
Lockery JE, Ernst ME, Broder JC, Orchard SG, Murray A, Nelson MR, Stocks NP, Wolfe R, Reid CM, Liew D, Woods RL; ASPREE Investigator Group. Prescription Medication Use in Older Adults Without Major Cardiovascular Disease Enrolled in the Aspirin in Reducing Events in the Elderly (ASPREE) Clinical Trial. Pharmacotherapy 2020; Oct;40(10):1042-1053, doi:10.1002/phar.2461. medications, poly pharmacy, prescriptions
Robman LD, Thao LTP, Guymer RH, Wolfe R, Woods RL, Hodgson LAB, Phung J, Makeyeva GA, Le-Pham YA, Orchard SG, Suleiman J, Maguire E, Trevaks RE, Ward SA, Riaz M, Lacaze P, Elsdon S, Abhayaratna WP, Nelson MR, Ernst ME, Reid CM, McNeil JJ; ASPREE Investigator Group. Baseline characteristics and age-related macular degeneration in participants of the "ASPirin in Reducing Events in the Elderly" (ASPREE)-AMD trial. Contemporary Clinical Trials Communications 2020; 20: 100667,  doi:10.1016/jconctc.2020.100667 [published online 2020 Oct. 11]. aspirin, AMD, age related macular degeneration, age-related, substudy, sub-study, eye health, vision, retinal, haemorrhages, hemorrhages, wet, dry
Eisen DP, Leder K, Woods RL, Lockery JE, McGuinness SL, Wolfe R, Pilcher D, Moore EM, Shastry A, Nelson MR, Reid C, McNeil, JJ, McBryde ES. Effect of aspirin on deaths associated with sepsis in healthy older people (ANTISEPSIS): a randomised, double-blind, placebo-controlled primary prevention trial. The Lancet Respiratory Medicine 2020,  doi.org/10.1016/S2213-2600(20)30411-2 [published online 2020 Sept. 17]. aspirin, sepsis, death, mortality, hospitalisations, hospitalizations, substudy, sub-study
Gilmartin-Thomas JFM, Ernst ME, Nelson MR, Lockery JE, Ward SA, Woods RL, Britt C, Murray A, Workman B, McNeil JJ; ASPREE Investigator Group. Musculoskeletal Pain Experienced on Most Days is a Common Accompaniment of Ageing amongst Community-Dwelling Older Australians: A Questionnaire-Based Study. Journal of Aging and Health 2020,  doi:10.1177/0898264320952914 [pre-print published online 2020 Sept. 11]. pain, muscle, back, knee, analgesia, medications, pharmacy, ALSOP, substudy, sub-study, questionnaires
Wolfe R, Wetmore JB, Wood RL, McNeil JJ, Gallagher H, Roderick P, Walker R, Nelson MR, Reid CM, Shah RC, Ernst ME, Lockery JE, Tonkin AM, Abhayaratna WP, Gibbs P, Wood EM, Mahady SE, Williamson JD, Donnan GA, Cloud GC, Murray AM, Polkinghorne K, for the ASPREE Investigator Group. Subgroup analysis of the ASPirin in Reducing Events in the Elderly randomized clinical trial suggest aspirin did not improve outcomes in older adults with chronic kidney disease. Kidney International 2020,  doi.org/10.1016/j.kint.2020.08.011  [published online 2020 Sept. 10]. aspirin, kidney, renal, GFR, CKD, urine, chronic kidney disease, aspirin, glomerular filtation rate
Gilmartin-Thomas JFM, Cicuttini FM, Owen AJ, Wolfe R, Ernst ME, Nelson MR, Lockery J, Woods RL, Britt C, Liew D, Murray A, Workman B, Ward SA, McNeil JJ; ASPREE Investigator Group. Moderate or severe low back pain is associated with body mass index amongst community-dwelling older Australians. Arch Gerontol & Geriatrics 91; Nov-Dec 2020, 104231, doi:10.1016/j.archger.2020.104231[published online 2020 Aug. 13]. pain, muscle, back, body mass, obesity, ALSOP, substudy, sub-study, questionnaires
McNeil JJ, Gibbs P, Orchard SG, Lockery JE, Bernstein WB, Cao Y, Ford L, Haydon A, Kirpach B, Macrae F, McLean C, Millar J, Murray AM, Nelson MR, Polekhina G, Reid CM, Richmond E, Rodríguez LM, Shah RC, Tie J, Umar A, van Londen GJ, Ronaldson K, Wolfe R, Woods RL, Zalcberg J, Chan A, for the ASPREE investigator Group. Effect of aspirin on cancer incidence and mortality in older adults. JNCI: Journal of the National Cancer Institute, djaa114, doi.org/10.1093/jnci/djaa114 [accepted manuscript published online 2020 Aug. 11]. aspirin, cancers, mortality, deaths, neoplasms, diagnosis, endpoints, end-points, end points, chemoprotective, incidence, CRC, metastasis, non-metastatic, metastatic
Ryan J, Woods RL, Britt CJ, Murray AM, Shah RC, Reid CM, Wolfe R, Nelson MR, Orchard SG, Lockery JE, Trevaks RE, Storey E, for the ASPREE Investigator Group. Normative Data for the Symbol Digit Modalities Test in Older White Australians and Americans, African-Americans, and Hispanic/Latinos. J Alzheimer’s Disease Reports 2020;4: 313-23,  doi: 10.3233/ADR-200194 [published online 2020 Aug. 04]. Alzheimer's disease, Alzheimers, cognition, dementia, SDMT, MMMs, MMMS, 3MS, 3ms, cognitive, characteristics, neurological
Mahady SE, Margolis KL, Chan A, Polekhina G, Woods RL, Wolfe R, Nelson MR, Lockery JE, Wood EM, Reid C, Ernst ME, Murray A, Thao LTP, McNeil JJ. Major GI bleeding in older persons using aspirin: incidence and risk factors in the ASPREE randomised controlled trial. Gut 2020,  doi:10.1136/gutjnl-2020-321585 [published online 2020 Aug. 03]. aspirin, bleeding, bleed, haemorrhages, hemorrhages, GI, gastrointestinal, risks, factors
Orchard SG, Lockery JE, Gibbs P, Polekhina G, Wolfe R, Zalcberg J, Haydon A, McNeil JJ, Nelson MR, Reid CM, Kirpach B, Murray AM, Woods RL, for the ASPREE investigator Group. Cancer history and risk factors in healthy older people enrolling in the ASPREE clinical trial. Contemporary Clinical Trials 2020; Sept.  doi.org/10.1016/j.cct.2020.106095 [published online 2020 July 31]. aspirin, bleeding, bleed, haemorrhages, hemorrhages, GI, gastrointestinal, risks, factors
Orchard ER, Ward PGD, Sforazzini F, Storey E, Egan G, Jamadar SD. Relationship between parenthood and cortical thickness in late adulthood. PLoS One 2020; 15(7):e0236031, doi:10.1371/journal.pone.0236031 [published online 2020 July 28]. MRI, brain, neural changes, cortical, cognition, cognitive, parents, parenthood, parity, neurological
Ward PDG, Orchard ER, Oldham S, Arnatkevičiūtė A, Sforazzini F, Fornito A, Storey E, Egan G, Jamadar SD. Individual differences in haemoglobin concentration influence bold fMRI functional connectivity and its correlation with cognition. NeuroImage 2020; 221:117196, doi:10.1016/j.neuroimage.2020.117196 [published online ahead of print 2020 July 25]. brain, haemoglobin, hemoglobin, cognitive, cognition, functional, connectivity, connectome, MRI, fMRI, neurological
Ernst ME, Chowdhury EK, Nelson MR, Reid CM, Margolis KL, Beilin LJ, Stocks N, Murray AM, Wolfe R, Lockery JE, Orchard SG, Woods RL, McNeil JJ; the ASPREE Investigator Group. Antihypertensive medications use and blood pressure control among treated older adults. J Clin Hypertens. 2020; 00: 1– 9,  doi.org/10.1111/jch.13934 [published online 2020 July 15]. anti-hypertensives, hypertension, blood pressure, medications, poly pharmacy, prescriptions
Fransquet PD, Lacaze P. Saffery R, Phung J, Parker E, Shah R, Murray A, Woods RL, Ryan J. Blood DNA methylation signatures to detect dementia prior to overt clinical symptoms. Alzheimer’s & Dementia 2020; 12:e12056,  doi: 10.1002/dad2.12056 [published online 2020 July 7]. biomarkers, blood, DNA, DNAm, methylation, dementia, Alzheimers disease, Alzheimer's, cognition, cognitive, epigenetics, biobank, sub-study, substudy
Davis SR, Garcia AM, Robinson PJ, Handelsman DJ, Desai R, Wolfe R, Bell RJ, the ASPREE Investigator Group. Estrone is a strong predictor of circulating estradiol in women aged 70 years and older, The Journal of Clinical Endocrinology & Metabolism, 2020; dgaa429,  doi.org/10.1210/clinem/dgaa429 [accepted manuscript 2020 July 02]. women, females, estrone, oestrone, estradiol, oestradiol, blood, blood, levels, androgen, oestrogen, postmenopause, sex hormones, substudy, sub-study, biobank, steroids
Lacaze P, Sebra R, Riaz M, Tiller J, Revote J, Phung J, Parker EJ, Orchard SG, Lockery JE, Wolfe R, Strahl M, Wang YC, Chen R, Sisco D, Arnold T, Thompson BA, Buchanan DD, Macrae FA, James PA, Abhayaratna WP, Lockett TJ, Gibbs P, Tonkin AM, Nelson MR, Reid CM, Woods RL, Murray AM, Winship I, McNeil JJ, Schadt E. Medically actionable pathogenic variants in a population of 13,131 healthy elderly individuals. Genet Med. 2020; Nov;22(11):1883-1886, doi: 10.1038/s41436-020-0881-7 [epub 2020 July 1]. PMID: 32606442; PMCID: PMC7606791 genomics, genome, DNA, pathogenic, genes, variants, PV, carriers, penetrance, Lynch syndrome, BRCA, BRCA1, BRCA2, LDLR, APOB, PCSK9, genetic testing, familial, biobank, substudy, sub-study
Zhou Z, Ofori-Asenso R, Curtis A, Breslin M, Wolfe R, McNeil JJ, Murray AM, Ernst ME, Reid CM, Lockery JE, Woods RL, Tonkin AM, Nelson MR. Association of Statin Use with Disability-Free Survival and Cardiovascular Disease among Healthy Older Adults. J Amer Coll Cardiol. 2020; June 30; 76: 17-27,  doi:10.1016/j.jacc.2020.05.016. statins, CVD, medications, prescriptions, pharmacy, cardiovascular, heart, stroke, disability, disability-free, mortality, deaths, dementia
Lewis JP, Riaz M, Xie S, Polekhina G, Wolfe R, Nelson M, Tonkin AM, Reid CM, Murray AM, McNeil JJ, Shuldiner AR, Lacaze P. Genetic variation in PEAR1, cardiovascular outcomes and effects of aspirin in a healthy elderly population. Clin Pharmacol Ther. 2020, doi: 10.1002/cpt.1959 [online ahead of print 2020 June 20]. PMID: 32562573 aspirin, PEAR1, platelet, receptor, CVD, cardiovascular, haemorrhage, hemorrhage, genes, genetic testing, genomics, hypercholesterolemia, hypercholesterolaemia, biobank
Lacaze P, Sebra R, Riaz M, Hooper AJ, Tiller J, Bakshi A, Woods RL, Tonkin AM, Reid CM, Murray AM, Nicholls SJ, Watts GF, Schadt E, McNeil JJ. Familial Hypercholesterolemia in a Healthy Elderly Population. Circ Genom Precis Med. 2020; June 10,  doi:10.1161/CIRCGEN.120.002938 [epub ahead of print]. genomics, genomes, DNA, pathogenic, genes, variants, PV, carriers, genetic testing, familial, CVD, cardiovascular, heart, stroke, cholesterol, hypercholesterolemia, hypercholesterolaemia, cholesterol, biobank, sub-study, substudy
Berk M, Woods RL, Nelson MR, Shah RC, Reid CM, Storey E, Fitzgerald S, Lockery JE, Wolfe, R, Mohebbi M, Dodd S, Murray AM, Stocks N, Fitzgerald P, Mazza C, Agustini B, McNeil JJ.  Effect of Aspirin vs Placebo on the Prevention of Depression in Older People: A Randomized Clinical Trial. JAMA Psychiatry 2020, doi:10.1001/jamapsychiatry.2020.1214 [published online 2020 June 03].  aspirin, depression, CES-D, CES-D-10, CESD, depressive, cognitive, mood, mental, endpoints, end-points, end points, sub-study, substudy, prevention, psychiatry
Agustini B, Lotfaliany M, Woods RL, McNeil JJ, Nelson MR, Shah RC, Murray AM, Ernst M, Reid CM, Tonkin A, Storey E, Lockery JE, Williams LJ, Berk M, Mohebbi M, on behalf of the ASPREE investigators. Patterns of association between depressive symptoms and chronic medical morbidities in older adults. J Amer Geriatrics Soc. 2020, doi 10.1111/jgs.16468 [published online 2020 May 13].  depression, CES-D, CES-D-10, CESD , depressive, cognitive, mood, mental, co-morbidity, comorbidity, co-morbidities, comorbidities
Woods RL, Polekhina G, Wolfe R, Nelson MR, Ernst ME, Reid CM, Shah RC, Lockery JE, Orchard SG, Murray AM, McNeil JJ, on behalf of the ASPREE Investigator Group. No modulation of aspirin’s effect by body weight in healthy older men and women. Circulation 2020; Mar. 30,  doi.org/10.1161/CIRCULATIONAHA.119.044142. aspirin, BMI, weight, anthropometric, dose, dosage, CVD, cardiovascular, heart, stroke
Ryan J, Storey E, Murray AM, Woods RL, Wolfe R, Reid CM, Nelson MR, Chong T, Williamson JD, Ward SA, Lockery JE, Orchard SG, Trevaks R, Kirpach B, Newman AB, Ernst ME, McNeil JJ, Shah RC. Randomized Placebo-controlled Trial of the effects of Aspirin on Dementia and Cognitive Decline. Neurology 2020; Mar. 25, doi.org/10.1212/WNL.0000000000009277. aspirin, cognitive decline, cognition, dementia, Alzheimer's disease, Alzheimers, MCI, 3MS, MMMs, 3ms, MMMS, endpoints, end-points, end points
Barker AL, Soh SE, Sanders KM, Pasco J, Khosla S, Ebeling PR, Ward SA, Peeters G, Talevski J, Cumming RG, Seeman E, McNeil JJ. Aspirin and fracture risk: a systematic review and exploratory meta-analysis of observational studies. BMJ Open 2020; Feb. 20;10(2):e026876,  doi: 10.1136/bmjopen-2018-026876. aspirin, fractures, falls, bone, risks, BMD
Ryan J, Woods RL, Murray AM, Shah RC, Britt C, Reid CM, Wolfe R, Nelson MR, Lockery JE, Orchard SG, Trevaks R, Chong T, McNeil JJ, Storey E. Normative Performance of Older Individuals on the Hopkins Verbal Learning Test-Revised (HVLT-R) According to Ethno-Racial Group, Gender, Age and Education Level. The Clinical Neuropsychologist 2020; Feb. 26,  doi:10.1080/13854046.2020.1730444. Alzheimer's disease, Alzheimers, cognition, dementia, cognitive, HVLTR, HVLT-R, Hopkins, verbal, delayed, recall
Agustini B, Mohebbi M, Woods RL, McNeil JJ, Nelson MR, Shah RC, Murray AM, Ernst ME, Reid CM, Tonkin A, Lockery JE, Berk M, on behalf of the ASPREE Investigator Group. The association of antihypertensive use and depressive symptoms in a large older population with hypertension living in Australia and the United States. Journal of Human Hypertension 2020; Pubmed 32001828,  doi.org/10.1038/s41371-020-0303-y. depression, CES-D, CES-D-10, CESD, depressive, cognitive, mental, mood, hypertension, blood pressure, co-morbidity, comorbidity, co-morbidities, comorbidities, antihypertensive, beta blocker, calcium channel antagonist, angiotensin
Pinese M, Lacaze P, Rath E, Stone A, Brion MJ, Ameur A, Nagpal S, Puttick C, Husson S, Degrave D, Navin Cristina T, Kahl VS, Statham A, Woods R, McNeil J, Riaz M, Barr M, Nelson M, Reid C, Murray A, Shah R, Wolfe R, Atkins J, Fitzsimmons C, Cairns H, Green M, Carr V, Cowley M, Pickett H, James P, Powell J, Kaplan W, Gibson G, Gyllensten U, Cairns M, McNamara M, Dinger M, Thomas D. The Medical Genome Reference Bank contains whole genome and phenotype data of 2,570 healthy elderly. Nature Communications Online 2020; Jan. 23, doi:10.1038/s41467-019-14079-0. Medical Genome Reference Bank, genomes, genomics, sequencing, MGRB, DNA, phenotypes, variants, genes, blood, biobank, sub-study, substudy
Voskoboinik I, Lacaze P, Jang HS, Flinsenberg TWH, Fernando SL, Kerridge I, Riaz M, Sebra R, Thia KYT, Noori T, Schadt EE, McNeil JJ, Trapani JA. Prevalence and Disease Predisposition of p.A91V perforin in an aged Caucasian Population. Blood Journal 2020, doi:10.1182/blood-2019003487 [epub ahead of print 2020 Jan. 13]. genomes, genomics, variants, genes, cancers, perforin, PRF1, biomarkers, blood, biobank
Lockery JE, Rigby J, Collyer TA, Stewart A, Woods RL, McNeil JJ, Reid CM, Ernst ME, on behalf of the ASPREE Investigator Group. Optimising medications data collection in a large-scale clinical trial. Plos One  2019; 14 (12), doi.org/10.1371/journal.pone.0226868. medications, methodology, methods, design, poly pharmacy, data, database, quality
Chowdhury EK, Nelson MR, Ernst ME, Margolis KL, Beilin LJ, Johnston CI, Woods RL, Murray AM, Wolfe R, Storey E, Shah RC, Lockery JE, Tonkin AM, Newman AB, Williamson JD, Abhayaratna WP, Stocks NP, Fitzgerald SM, Orchard SG, Trevaks RE, Donnan GA, Grimm R, McNeil JJ, Reid CM, for the ASPREE investigator Group. Factors associated with treatment and control of hypertension in a healthy elderly population free of cardiovascular disease: a cross-sectional study. American Journal of Hypertension 2019; Dec. 06, doi.org/10.1093/ajh/hpz192. anti-hypertensives, hypertension, blood pressure, medications, prescriptions, co-morbidity, comorbidity, co-morbidities, comorbidities
Jamadar SD, Sforazzini F, Raniga P, Ferris NJ, Paton B, Bailey MJ, Brodtmann A, Yates PA, Donnan GA, Ward SA, Woods RL, Storey E, McNeil JJ, Egan GF;  ASPREE Investigator Group. Sexual Dimorphism of Resting-State Network Connectivity in Healthy Ageing. The journals of gerontology. Series B, Psychological sciences and social sciences 2019; 74 (7): 1121-1131, doi:10.1093/geronb/gby004. sex, gender, males, females, cognition, brain, cognitive, neuroscience, connectivity
Lockery JE, Collyer TA, Reid CM, Ernst ME, Gilbertson D, Hay N, Kirpach B, McNeil JJ, Nelson MR, Orchard SG, Pruksawongsin K, Shah RC, Wolfe R, Woods RL, on behalf of the ASPREE Investigator Group. Overcoming challenges to data quality in the ASPREE clinical trial. Trials 2019; 20: 686, doi:10.1186/s13063-019-3789-2. data, quality, database, AWARD, costs, framework, methodology, methods, design
Davis SR, Bell RJ, Robinson PJ, Handelsman DJ, Gilbert T, Phung J, Desai R, Lockery JE, Woods RL, Wolfe RS, Reid CM, Nelson  MR, Murray AM, McNeil JJ. Testosterone and estrone increase from the age of 70 years; findings from the Sex Hormones in Older Women Study. J Clinical Endocrinology & Metabolism 2019; Aug. 13; pii: jc.2019-00743,  doi: 10.1210/jc.2019-00743 [epub ahead of print]. women, females, estrone, oestrone, estradiol, oestradiol, testosterone, androgen, sex hormones, blood, serum, oestrogen, postmenopause, sub-study, substudy, biobank, steroids
Agustini B, Mohebbi M, Woods RL, McNeil JJ, Nelson MR, Shah RC, Murray AM, Ernst ME, Reid CM, Tonkin A, Lockery JE, Berk M; ASPREE Investigator Group. Association Between Statin Use and Depressive Symptoms in a Large Community-Dwelling Older Population Living in Australia and the USA: A Cross-Sectional Study. CNS Drugs 2019; May 6,  doi: 10.1007/s40263-019-00633-3 [epub ahead of print]. depression, mental, mood, statins, depressive, CES-D, CES-D-10, CESD, cholesterol, inflammation, psychiatry
Polkinghorne KR, Wolfe R, Jachno KM, Wetmore JB, Woods RL, McNeil JJ, Nelson MR, Reid CM, Murray AM; ASPREE Investigator Group. Prevalence of chronic kidney disease in the elderly using the ASPirin in Reducing Events in the Elderly study cohort. Nephrology 2019; 24:1248-1256,  doi: 10.1111/nep.13565. CKD, renal, kidney, GFR, uACR, glomerular filtation rate, albuminuria
Mohebbi M, Agustini B, Woods RL, McNeil JJ, Nelson MR, Shah RC, Nguyen V, Storey E, Murray AM, Reid CM, Kirpach B, Wolfe RS, Lockery JE, Berk M; ASPREE Investigator Group. Prevalence of depressive symptoms and its associated factors among healthy community-dwelling older adults living in Australia and the United States. Int J Geriatr Psychiatry 2019; Apr. 16,  doi: 10.1002/gps.5119 [epub ahead of print]. depression, mental, mood, depressive, CES-D, CES-D-10, CESD, sub-study, substudy, prevalence, incidence, risk factors, psychiatry
Lockery JE, Collyer TA, Abhayaratna WP, Fitzgerald SM, McNeil JJ, Nelson MR, Orchard SG, Reid C, Stocks NP, Trevaks RE, Woods RL. Recruiting general practice patients for large clinical trials: lessons from the Aspirin in Reducing Events in the Elderly (ASPREE) study. Med J Aust 2019; 210 (4): 168-173, doi: 10.5694/mja2.12060. recruitment, recruiting, methodology, methods, design, GPs, general practice, barriers, opportunities, doctors, physicians, enrolment, enrollment
CORRESPONDENCE McNeil JJ, Woods RL, Murray AM, for the ASPREE Investigator Group. Effects of aspirin in the healthy elderly. Correspondence. N Engl J Med 2019; 380 (18): 1776-7,  doi:10.1056/NEJMc1901774. aspirin, placebo, CVD, cardiovascular, disability, disability-free, survival, bleeds, bleeding, haemorrhages, hemorrhages, mortality, cancers, benefits, risks
COMMETARY Chan AT, McNeil J. Aspirin and Cancer Prevention in the Elderly: Where Do We Go From Here? Gastroenterology. 2019 Feb; 156(3):534-538,  doi: 10.1053/j.gastro.2018.11.063. aspirin, cancers, deaths, mortality, morbidity
McNeil JJ, Woods RL, Ward SA, Britt CJ, Lockery JE, Beilin LJ, Owen AJ. Cohort Profile: The ASPREE Longitudinal Study of Older Persons (ALSOP). International Journal of Epidemiology 2019,  doi.org/10.1093/ije/dyy279. ALSOP, sub-study, substudy, longitudinal, questionnaires, physical, health, lifestyle factors, methodology, methods, design, characteristics
Lacaze P, Pinese M, Kaplan W, Stone A, Brion M, Woods RL, McNamara M, McNeil JJ, Dinger ME, Thomas DM. The Medical Genome Reference Bank: a whole-genome data resource of 4,000 healthy elderly individuals. Rationale and cohort design. European Journal of Human Genetics 2018, doi: 10.1038/s41431-018-0279-z. genomics, genomes, DNA, pathogenic, genes, variants, PV, carriers, genetic testing, whole-genome, familial, methodology, methods, design, MGRB, biobank, blood, substudy, sub-study
Stocks N, González-Chica DA, Lockery JE, Shah RC, Murray AM, Wolfe R, Nelson MR, Reid CM, McNeil JJ, Woods RL, on behalf of the ASPREE Investigator Group. Quality of Life for 19,114 participants in the ASPREE (Aspirin in Reducing Events in the Elderly) Study and their association with sociodemographic and lifestyle modifiable risk factors. Quality of Life Research 2018, pp.1-12, doi: 10.1007/s11136-018-2040-z. socio demographic, lifestyle, QOL, quality, health, HRQoL, mental, SF-12, mood, physical, risk factors
McNeil JJ*, Woods RL*, Nelson MR, Reid CM, Kirpach B, Wolfe R, Storey E, Shah RC, Lockery JE, Tonkin AM, Newman AB, Williamson JD, Margolis KL, Ernst ME, Abhayaratna WP, Stocks N, Fitzgerald SM, Orchard SG, Trevaks RE, Beilin LJ, Donnan GA, Gibbs P, Johnston CI, Ryan J, Radziszewska B, Grimm R & Murray AM, on behalf of the ASPREE Investigator Group (* joint first authors). Effect of aspirin on disability-free survival in the healthy elderly. New England Journal of Medicine 2018; 379:1499-1508, doi: 10.1056/nejmoa1800722 [published online Sept. 2018]. aspirin, disability, disability-free, survival, health, lifespan, haemorrhages, hemorrhages, bleeds, bleeding, dementia, cognitive decline, cognition, ADLs, physical, disability, mortality, fatal, endpoints, end-points, end points, outcomes, cancers, CVD, cardiovascular, diseases, stroke, heart, depression, risk-benefit, risks, benefits, new england journal, NEJM, design, methodology, methods
McNeil JJ*, Nelson MR*, Woods RL, Lockery JE, Wolfe R, Reid CM, Kirpach B, Shah RC, Ives DG, Storey E, Ryan J, Tonkin AM, Newman AB, Williamson JD, Margolis KL, Ernst ME, Abhayaratna WP, Stocks N, Fitzgerald SM, Orchard SG, Trevaks RE, Beilin LJ, Donnan GA, Gibbs P, Johnston CI, Radziszewska B, Grimm R & Murray AM, on behalf of the ASPREE Investigator Group (* joint first authors). Effect of aspirin on all-cause mortality in the healthy elderly. New England Journal of Medicine 2018; 379:1499-1508,  doi: 10.1056/NEJMoa1803955 [published online Sept. 2018]. aspirin, disability, disability-free, survival, health, lifespan, haemorrhages, hemorrhages, bleeds, bleeding, CVD, cardiovascular, stroke, disease, dementia, physical, mortality, morbidity, death, fatal, cancers, endpoints, end-points, end points, outcomes, risk-benefit, risks, benefits, new england journal, NEJM
McNeil JJ, Wolfe R, Woods RL, Tonkin AM, Donnan GA, Nelson MR, Reid CM, Lockery JE, Kirpach B, Storey E, Shah RC, Williamson JD, Margolis KL, Ernst ME, Abhayaratna WP, Stocks N, Fitzgerald SM, Orchard SG, Trevaks RE, Beilin LJ, Johnston CI, Ryan J, Radziszewska B, Jelinek M, Malik M, Eaton C, Brauer D, Cloud G, Wood E, Mahady SE, Satterfield S, Grimm R & Murray AM, on behalf of the ASPREE Investigator Group. Effect of aspirin on cardiovascular events and bleeding in the healthy elderly. New England Journal of Medicine 2018; 379:1499-1508,  doi: 10.1056/nejmoa1805819 [published online Sept. 2018]. aspirin, disability, disability-free, survival, health, lifespan, haemorrhages, hemorrhages, bleeds, bleeding, CVD, cardiovascular, stroke, MACE, coronary, cardiac, heart failure, cerebral, diseases, physical, mortality, morbidity, death, fatal, endpoints, end-points, end points, outcomes, risk-benefit, risks, benefits, new england journal, NEJM
Ryan J, Woods RL, Britt C, Murray AM, Shah RC, Reid CM, Kirpach B, Wolfe RS, Nelson MR, Lockery JE, Orchard SG, Trevaks RE, McNeil JJ, Storey E, on behalf of the ASPREE Investigator Group. Normative performance of healthy older individuals on the Modified Mini-Mental State (3MS) examination according to ethno-racial group, gender, age, and education level. The Clinical Neuropsychologist 2018,  doi.org/10.1080/13854046.2018.1488996 [published online July 2018]. cognitive decline, cognition, dementia, Alzheimer's disease, Alzheimers, cognitive, MCI, aspirin, memory, 3MS, 3ms, MMMS, MMMS, characteristics
Margolis KL, Mahady SE, Nelson MR, Ives DG, Satterfield S, Britt C, Ekram S, Lockery JE, Schwartz EC, Woods RL, McNeil JJ, Wood EM. Development of a standardized definition for clinically significant bleeding in the ASPirin in Reducing Events in the Elderly (ASPREE) trial. Contemporary Clinical Trials Communications 2018; Vol 11, 30-36, doi.org/10.1016/j.conctc.2018.05.015. aspirin, methods, methodology, design, bleeding, bleeds, haemorrhages, hemorrhages, risk-benefit, risks, benefits, endpoints, end-points, gastrointestinal, brain, cerebral, stroke
Wolfe R, Murray AM, Woods, RL, Kirpach B, Gilbertson D, Shah RC, Nelson MR, Reid CM, Ernst ME, Lockery JE, Donnan GA, Williamson J, McNeil JJ. The aspirin in reducing events in the elderly trial: Statistical analysis plan. International Journal of Stroke 2018; Vol.13(3), pp.335-338,  doi.org/10.1177/1747493017741383. aspirin, methods, statistical analysis plan, statistics, protocol, design, disability, disability-free, survival, health, lifespan, haemorrhage, hemorrhage, bleed, CVD, cardiovascular, stroke, disease, dementia, physical, disability, mortality, morbidity, death, fatal, cancers, endpoints, end-points, end points, risk-benefit, risks, benefits
Fransquet PD, Lacaze P, Woods RL, McNeil JJ, Saffery R, Ryan J. Blood DNA methylation as a potential biomarker of dementia: a systematic review. Alzheimer’s & Dementia 2017; 14(1): 81-103. IF:11.0,  doi: 10.1016/j.jalz.2017.10.002. biomarkers, blood, DNA, DNAm, methylation, dementia, Alzheimers diease, Alzheimer's, cognition, cognitive, epigenetics, biobank
Ward SA, Storey E, Woods RL, Hamilton GS, Kawasaki R, Janke AL, Naughton MT, O’Donoghue F, Wolfe R, Wong TY, Reid CM, Abhayaratna WP, Stocks N, Trevaks R, Fitzgerald S, Hodgson LAB, Robman L,  Workman  B, McNeil JJ. The Study of Neurocognitive Outcomes, Radiological and Retinal Effects of Aspirin in Sleep Apnoea- rationale and methodology of the SNORE-ASA study. Contemporary clinical trials 2018; Vol.64, pp.101-111,  doi.org/10.1016/j.cct.2017.10.016. cognitive decline, cognition, dementia, Alzheimer's disease, Alzheimers, cognitive, MCI, aspirin, memory, 3MS, MMMs, methods, methodology, design, apnoea, apnea, retinal, substudy, sub-study
Mohebbi M, Nguyen V, McNeil JJ, Woods RL, Nelson MR, Shah RC, Storey E, Murray AM, Reid CM, Kirpach B, Wolfe, R, Lockery JE, Berk M, on behalf of the ASPREE investigator group. Psychometric properties of a short form of the Center for Epidemiologic Studies Depression (CES-D-10) scale for screening depressive symptoms in healthy community dwelling older adults. General Hospital Psychiatry 2018; 51:118-125,  doi: 10.1016/j.genhosppsych.2017.08.002. depression, mental, mood, depressive, CES-D, CES-D-10, CESD, methods, methodology, design, psychometrics, validation, substudy, sub-study, psychiatry
McNeil JJ, Woods RL, Nelson MR, Murray AM, Reid CM, Kirpach B, Storey E, Shah RC, Wolfe R, Tonkin AM, Newman AB, Williamson JD, Lockery JE, Margolis KL, Ernst ME, Abhayaratna WP, Stocks N, Fitzgerald SM, Trevaks RE, Orchard SG, Beilin LJ, Donnan GA, Gibbs P, Johnston CI, Grimm RH, on behalf of the ASPREE investigator group. Baseline Characteristics of Participants in the ASPREE (ASPirin in Reducing Events in the Elderly) Study. J Gerontol A Biol Sci Med Sci 2017; Oct. 12, Vol. 00, No. 00, 1–8,  doi:10.1093/gerona/glw342. baseline, characteristics, cohort, recruitment, design, methods, methodology, disability, disability-free, survival, health, lifespan, haemorrhages, hemorrhages, dementia, cognitive decline, physical, disability, mortality, fatal, endpoint, end-point, end point, outcome, cancers, CVD, cardiovascular, disease, depression, depressive
Ward SA, Raniga P, Ferris NJ, Woods RL, Storey E, Bailey MJ, Brodtmann A, Yates PA, Donnan GA, Trevaks RE, Wolfe R, Egan GF, McNeil JJ; (Joint Senior authorship), on behalf of the ASPREE investigator group. ASPREE-NEURO study protocol: A randomized controlled trial to determine the effect of low-dose aspirin on cerebral microbleeds,white matter hyperintensities, cognition, and stroke in the healthy elderly. Int J Stroke 2017; 12(1):108-113,  doi:10.1177/1747493016669848. aspirin, neuroimaging, dementia, cognitive decline, MRI, neuroscience, design, methods, methodology, stroke
Robman L, Guymer R, Woods RL, Ward SA, Wolfe R, Phung J, Hodgson L, Makeyeva G, Aung KZ, Gilbert T, Lockery JE, Le-Pham Y, Orchard S, Storey E, Abhayaratna W, Reid D, Ernst ME, Nelson MR, Reid C,  McNeil, JJ. Age-related macular degeneration in a randomized controlled trial of low-dose aspirin: Rationale and study design of the ASPREE-AMD study. Contemporary Clinical Trials Communications 2017; Vol.6, pp.105-114, doi:10.1016/j.conctc.2017.03.005. aspirin, AMD, age related macular degeneration, age-related, substudy, sub-study, eye health, vision, retinal, haemorrhages, hemorrhages, design, method, methdology
Lacaze P, Ryan J, Woods RL, Winship I, McNeil JJ. Pathogenic variants in the healthy elderly: unique ethical and practical challenges. Journal of Medical Ethics, 2017; Vol. 43(10), p.714,  doi: 10.1136/medethics-2016-103967. biomarkers, genomics, genomes, DNA, pathogenic, genes, variants, PV, carriers, penetrance, genetic testing, familial, substudy, sub-study
Lacaze P, Woods RL, Zoungas S, McNeil JJ. The genomic potential of the Aspirin in Reducing Events in the Elderly and Statins in Reducing Events in the Elderly studies. Internal medicine Journal 2017; Vol.47(4), pp.461-463,  doi.org/10.1111/imj.13384. genomics, genomes, DNA, pathogenic, genes, variants, PV, carriers, penetrance, genetic testing, familial, substudy, sub-study
Eisen DP, Moore EM, Leder K,  Lockery JE, McBryde ES, McNeil JJ, Pilcher D, Wolfe R, Woods RL. AspiriN To Inhibit SEPSIS (ANTISEPSIS) randomised controlled trial protocol. BMJ Open 2017;7:e013636,  doi: 10.1136/bmjopen-2016-013636. aspirin, sepsis, death, mortality, hospitalisation, hospitalization, design, methods, methodology, protocol, substudy, sub-study
Lacaze P, Winship I, McNeil J. Penetrance and the Healthy Elderly. Genet Test Mol Biomarkers 2017; Nov 21(11):637-640,  doi: 10.1089/gtmb.2017.0126 [epub 2017 Sept. 6]. genomics, genome, DNA, pathogenic, genes, variants, PV, carriers, penetrance, genetic testing, familial, substudy, sub-study
Berk M, Woods RL, Nelson MR, Shah RC, Reid CM, Storey E, Fitzgerald SM, Lockery JE, Wolfe R, Mohebbi M, Murray AM, Kirpach B, Grimm R, McNeil JJ. ASPREE-D: Aspirin for the prevention of depression in the elderly. International Psychogeriatrics 2016,  doi:10.1017/S104161021600079X. aspirin, depression, CES-D, CES-D-10, CESD, depressive, cognitive, mood, mental, methods, methodology, design, substudy, sub-study, protocol, psychiatry
Lowthian JA, Britt CJ, Rance G, Lin FR, Woods RL, Wolfe R, Nelson MR, Dillon HA, Ward S, Reid CM, Lockery JE, Nguyen TT, McNeil JJ, Storey E. Slowing the progression of age-related hearing loss: Rationale and study design of the ASPIRIN in HEARING, retinal vessels imaging and neurocognition in older generations (ASPREE-HEARING) trial. Contemp Clin Trials 2015; 46; 60-66,  doi: 10.1016/j.cct.2015.11.014. aspirin, hearing loss, cognitive, cognition, retinal, audiometry, ARHL, design, methods, methodology, substudy, sub-study
Barker AL, McNeil JJ, Seeman E, Ward SA, Sanders KM, Khosla S, Cumming RG, Pasco JA, Bohensky MA, Ebeling PR, Woods RL, Lockery JE, Wolfe R, Talevski J, and the ASPREE Investigator Group. A randomised controlled trial of low-dose aspirin for the prevention of fractures in healthy older people: protocol for the ASPREE-Fracture substudy. Inj Prev. 2015; pii: injuryprev-2015-041655, doi: 10.1136/injuryprev-2015-041655 [epub ahead of print]. PMID: 26002770 aspirin, fractures, falls, bone, BMD, methods, methodology, design, substudy, sub-study
COMMENTARY Chong EW, Guymer RH, Robman LD. Does aspirin increase the risk of age-related macular degeneration? Expert Opinion on Drug Safety 2014; 13:691-3,  doi: 10.1517/14740338.2014.914169. aspirin, AMD, age related macular degeneration, age-related, eye health, vision, retinal, haemorrhage, hemorrhage, design, method, methdology, substudy, sub-study
ASPREE Investigator Group. Study design of ASPirin in Reducing Events in the Elderly (ASPREE): a randomized, controlled trial. Contemporary Clinical Trials 2013; 36: 555–564,  doi: org/10.1016%2Fj.cct.2013.09.014. aspirin, recruitment, GPs, general practice, methods, methodology
COMMENTARY Nelson MR. General practice-based clinical trials. Perspectives, Med J Aust 2013; 198 (3),  doi: 10.5694/mja12.11061. Rrecruitment, GPs, general practice, methods, methodology
Reid CM, Storey E, Wong TY, Woods RL, Tonkin A, Wang JJ, Kam A, Janke A, Essex R, Abhayaratna WP, Budge MM, on behalf of the ASPREE Study Group. Aspirin for the prevention of cognitive decline in the elderly: rationale and design of a neuro-vascular imaging study (ENVIS-ion). BMC Neurol. 2012; 12:3,  doi: 10.1186/1471-2377-12-3. envision, en-vision, cognitive decline, cognition, dementia, neuro, MRI, retinal, design, methods, methodology, substudy, sub-study
Linden MD, Tran HA, Woods RL, Tonkin AM. High platelet reactivity and antiplatelet therapy resistance. Seminars in Thrombosis and Hemostasis 2012; 38(2):200-12, doi: 10.1055/s-0032-1301417. aspirin, anti-platelet, antiplatelet, resistance, thrombosis, CVD, cardiovascular
COMMENTARY Ward SA, Demos L, Workman B, McNeil JJ. Aspirin for primary prevention of cardiovascular events in the elderly: current status and future directions. Drugs Aging 2012; Apr 1;29(4):251-8, doi.org/10.2165/11599030-000000000-00000. aspirin, anti-platelet, antiplatelet, resistance, thrombosis, CVD, cardiovascular, cardiac
EDITORIAL Woods RL, Tonkin AM, Nelson MR, Britt HC, Reid CM. Should aspirin be used for the primary prevention of cardiovascular disease in people with diabetes? Med J Aust. 2009; 190:614-5  PMID:19485837 aspirin, CVD, cardiovascular, stroke, heart, cardiac, diabetes
Nelson MR, Reid CM, Ames DA, Beilin LJ, Donnan GA, Gibbs P, Johnston CI, Krum H, Storey E, Tonkin A, Wolfe R, Woods R, McNeil JJ. Feasibility of conducting a primary prevention trial of low-dose aspirin for major adverse cardiovascular events in older people in Australia: results from the ASPirin in Reducing Events in the Elderly (ASPREE) pilot study. Med J Aust. 2008; 189:105-109, doi.org/10.5694/j.1326-5377.2008.tb01932.x. PMID:18637782 aspirin, design, method, methodology, CVD, cardiovascular, stroke, heart, cardiac, pilot
Nelson MR, Liew D, Bertram M, Vos T. Epidemiological modelling of routine use of low-dose aspirin in Australia for the primary prevention of coronary heart disease and stroke in those aged 70 years and above. BMJ 2005; 330:1306-1308, doi: 10.1136/bmj.38456.676806.8F. aspirin, design, method, methodology, CVD, cardiovascular, stroke, heart, cardiac
CONFERENCE PROCEEDINGS Nelson MR, Reid CM, Johnstone CI, Krum H, Storey E, Tonkin A, Beilin LJ, Donnan GA, McNeil JJ.  After ANBP2 – ASPREE  Clinical And Experimental Pharmacology And Physiology, Melbourne, Australia 2003; Vol.30(7), pp.A59-A59. aspirin, design, method, methodology, GPs, general practice, ANBP2
ASPREE Study Group. Nelson MR, Reid CM, Beilin LJ, Donnan GA, Johnston CI, Krum H, Storey E, Tonkin AM, McNeil JJ.  Rationale for a primary prevention trial in the elderly of low dose aspirin for the prevention of major adverse cardiovascular events and vascular dementia in Australian general practice.  ASPirin in Reducing Events in the Elderly (ASPREE). J Drugs and Aging 2003; 20(12):897-903, doi: 10.2165/00002512-200320120-00004. aspirin, design, method, methodology, CVD, cardiovascular, stroke, heart, cardiac, dementia, vascular, cognitive decline, GP, general practice, recruitment
Silagy CA, McNeil JJ, Donnan GA, Tonkin AM, Worsam B, Campion K. The PACE pilot study: 12-month results and implications for future primary prevention trials in the elderly. (Prevention with low-dose Aspirin of Cardiovascular disease in the Elderly). J Am Geriatr Soc. 1994; 42(6):643-64, doi: 10.1111/j.1532-5415.1994.tb06864.x. aspirin, cardiac, cardiovascular, pilot, aspirin, design, methodology
Silagy CA, McNeil JJ, Donnan GA, Tonkin AM, Worsam B, Campion K. Adverse effects of low-dose aspirin in a healthy elderly population. Clin Pharmacol Ther, 1993; 54(1):84-89, doi: 10.1038/clpt.1993.115. aspirin, adverse, risk, methodology, design, effects
Silagy CA, McNeil JJ, Bulpitt CJ, Donnan GA, Tonkin AM, Worsam B. Rationale for a primary prevention study using low-dose aspirin to prevent coronary and cerebrovascular disease in the elderly. J Am Geriatr Soc. 1991; 39(5):484-491, doi: 10.1111/j.1532-5415.1991.tb02494.x. aspirin, cardiac, cardiovascular, stroke, CVD, CVA, design, methodology
Campion K, Silagy CA, McNeil JJ, Donnan GA, Tonkin AM, Worsam B. Comparison of recruitment strategies for a large-scale multicentred clinical trial in the elderly. Community Health Stud, 1990; 14(4):400, doi: 10.1016/0895-4356(91)90013-y. recruitment, design, methodology

2021

  • Lacaze P, Bakshi A, Riaz M, Orchard SG, Tiller J, Neumann JT, Carr PR, Joshi AD, Cao Y, Warner ET, Manning A, Nguyen-Dumont T, Southey MC, Milne RL, Ford L, Sebra R, Schadt E, Gately L, Gibbs P, Thompson BA, Macrae FA, James P, Winship I, McLean C, Zalcberg JR, Woods RL, Chan AT, Murray AM, McNeil JJ. Genomic Risk Prediction for Breast Cancer in Older Women. Cancers. 2021 July 14; 13(14):3533, doi.org/10.3390/cancers13143533
  • Hu J, Fitzgerald SM, Owen AJ, Ryan J, Joyce J, Chowdhury E, Reid CM, Britt C, Woods RL, McNeil JJ, Freak-Poli R. Social isolation, social support, loneliness and cardiovascular disease risk factors: a cross-sectional study among older adults. Int J Geriatr Psychiatry. 2021 July 7; 1-15, doi: /10.1002/gps.5601
  • Phyo AZZ, Ryan J, Gonzalez-Chica DA, Stocks NP, Reid CM, Tonkin AM, Woods RL, Nelson MR, Murray AM, Gasevic D, Freak-Poli R. Health-related quality of life and incident cardiovascular disease events in community-dwelling older people: A prospective cohort study. International Journal of Cardiology. 2021, doi: /10.1016/j.ijcard.2021.07.004 [published online, 2021 July 7].
  • Zhou Z, Ryan J, Ernst ME, Zoungas S, Tonkin AM, Woods RL, McNeil JJ, Reid CM, Curtis AJ, Wolfe R, Wrigglesworth J, Shah RC, Storey E, Murray A, Orchard SG, Nelson MR. Effect of statin therapy on cognitive decline and incident dementia in older adults, J Am Coll Cardiol 2021 June 29; 77(25): 3145-56, doi:10.1016/j.jacc.2021.04.075
  • Ernst ME, Ryan J, Chowdhury EK, Margolis KL, Beilin LJ, Reid CM, Nelson MR, Woods RL, Shah RC, Orchard SG, Wolfe R, Storey E, Tonkin AM, Brodtmann A, McNeil JJ, Murray AM. Long-Term Blood Pressure Variability and Risk of Cognitive Decline and Dementia Among Older Adults. J Am Heart Assoc 2021, June 26 ;10:e019613, doi: 10.1161/JAHA.120.019613
  • Lacaze P, Sebra R, Riaz M, Ingles J, Tiller J, Thompson BA, James PA, Fatkin D, Semsarian C, Reid CM, Tonkin AM, Winship I, Schadt E, McNeil JJ. Genetic variants associated with inherited cardiovascular disorders among 13,131 asymptomatic older adults of European descent. NPJ Genom Med. 2021 Jun 16; 6(1):51, doi: 10.1038/s41525-021-00211-x. PMID: 34135346; PMCID: PMC8209162.
  • Neumann JT, Riaz M, Bakshi A, Polekhina G, Thao LTP, Nelson MR, Woods RL, Abraham G, Inouye M, Reid CM, Tonkin AM, Williamson JD, Donnan G, Brodtmann A, Cloud GC, McNeil JJ, Lacaze P. Predictive performance of a polygenic risk score for incident ischemic stroke in a healthy older population. Stroke 2021;52, doi:10.1161/STROKEAHA.120.033670 [epub ahead of print, May 27].
  • Riaz M, Huq A, Ryan J, Orchard SG, Tiller J, Lockery J, Woods RL, Wolfe R, Renton AE, Goate AM, Sebra R, Schadt E, Brodtmann A, Shah RC, Storey E, Murray AM, McNeil JJ, Lacaze P. Effect of APOE and a polygenic risk score on incident dementia and cognitive decline in a healthy older population. Aging Cell. 2021, doi: 10.1111/acel.13384. [epub ahead of print, May 26] PMID: 34041846.
  • Nunn JS, Sulovski M, Tiller J, Holloway B, Ayton D, Lacaze P. Involving elderly research participants in the co-design of a future multi-generational cohort study. Research Involvement and Engagement 7:23. 2021 May 3, doi.org/10.1186/s40900-021-00271-4
  • Wu Z, Woods RL, Wolfe R, Storey E, Chong TTJ, Shah RC, Orchard SG, McNeil JJ, Murray AM, Ryan J; the ASPREE Investigator Group. Trajectories of cognitive function in community‐dwelling older adults: A longitudinal study of population heterogeneity. Alzheimer’s Dement. 2021 May 2,  doi: org/10.1002/dad2.12180
  • Bakshi A, Yan M, Riaz M, Polekhina G, Orchard SG, Tiller J, Wolfe R, Joshi A, Cao Y, McInerney-Leo AM, Yanes T, Janda M, Soyer HP, Cust AE, Law MH, Gibbs P, McLean C, Chan AT, McNeil JJ, Mar VJ, Lacaze P. Genomic Risk Score for Melanoma in a Prospective Study of Older Individuals. J Natl Cancer Inst. 2021, doi: 10.1093/jnci/djab076 [epub ahead of print, 2021 April 10].
  • Lockery JE, Broder JC, Ryan J, Stewart AC, Woods RL, Chong TT, Cloud GC, Murray A, Rigby JD, Shah R, Storey E, Ward SA, Wolfe R, Reid CM, Collyer TA, Ernst ME; the ASPREE Investigator Group. A Cohort Study of Anticholinergic Medication Burden and Incident Dementia and Stroke in Older Adults. J Gen Intern Med. 2021, doi: 10.1007/s11606-020-06550-2 [published online, 2021 Mar. 22]. PMID: 33754317
  • Phyo AZZ, Gonzalez-Chica DA, Stocks NP, Storey E, Woods RL, Murray AM, Orchard SG, Shah RC, Gasevic D, Freak-Poli R, Ryan J; ASPREE Investigator Group. The Utility of Assessing Health-Related Quality of Life to Predict Cognitive Decline and Dementia. J Alzheimers Dis. 2012, doi: 10.3233/JAD-201349 [epub ahead of print 2021 Feb. 12]. PMID: 33579847
  • EDITORIAL McNeil JJ. Aspirin and primary prevention of colorectal cancer: a still evolving story. JNCI: Journal of the National Cancer Institute, 2021;djab010, doi.org/10.1093/jnci/djab010 [published online, 2021 Feb. 02].
  • Berk M, Agustini B, Woods RL, Nelson MR, Shah RC, Reid CM, Storey E, Fitzgerald S, Lockery JE, Wolfe R, Mohebbi M, Dodd S, Murray AM, Stocks N, Fitzgerald P, Mazza C, McNeil JJ. Effects of aspirin on the long-term management of depression in older people: a double-blind randomised placebo-controlled trial. Mol Psychiatry 2021,  doi.org/10.1038/s41380-021-01020-5 [published online, 2021 Jan. 27].
  • Phyo A, Ryan J, Gonzalez-Chica DA, Woods RL, Reid CM, Nelson MR, Murray AM, Gasevic D, Stocks NP, Freak-Poli R; the ASPREE Investigator Group. Health-related quality of life and all-cause mortality among older health individuals in Australia and the United States: a prospective cohort study. Quality of Life Research 2021; 30(4):1037-48, doi:10.1007/s11136-020-02723-y [published online, 2021 Jan. 03].

2020

  • Woods RL, Espinoza S, Thao LTP, Ernst ME, Ryan J, Wolfe R, Shah RC, Ward SA, Storey E, Nelson MR, Reid CM, Lockery JE, Orchard SG, Trevaks RE, Fitzgerald SM, Stocks NP, Williamson JD, McNeil JJ, Murray AM, Newman AB; ASPREE Investigator Group. Effect of Aspirin on Activities of Daily Living Disability in Community-Dwelling Older Adults. J Gerontol A Biol Sci Med Sci. 2020; glaa316, doi:10.1093/gerona/glaa316 [published online ahead of print, 2020 Dec. 26].
  • Islam RM, Bell RJ, Handelsman DJ, Robinson PJ, Wolfe R, Davis SR; ASPREE Investigator Group. Longitudinal changes over three years in sex steroid hormone levels in women aged 70 years and over. Clin Endocrinol (Oxf). 2020; Dec. 22, doi: 10.1111/cen.14401 [epub ahead of print]. PMID: 33351205
  • Lefevre A, Hopper I, McNeil JJ, Owen A; ALSOP Complementary Medicine Research Group. Complementary medicine use by community-dwelling older Australians [published online ahead of print, 2020 Dec 10]. Med J Aust. 2020; 10.5694/mja2.50884, doi:10.5694/mja2.50884 [published online ahead of print, 2020 Dec. 9].
  • Gilmartin-Thomas JF, Forbes A, Liew D, McNeil JJ, Cicuttini FM, Owen AJ, Ernst ME, Nelson MR, Lockery J, Ward SA, Busija L; ASPREE Investigator Group. Evaluation of the Pain Impact Index for community-dwelling older adults through the application of Rasch modelling. Pain Pract. 2020; Dec. 9, doi: 10.1111/papr.12980 [epub ahead of print]. PMID: 33295122
  • Chowdhury EK, Ernst ME, Nelson M, Margolis K, Beilin LJ, Johnston C, Woods R, Murray A, Wolfe R, Storey E, Shah RC, Lockery J, Tonkin A, Newman A, Abhayaratna W, Stocks N, Fitzgerald S, Orchard S, Trevaks R, Donnan G, Grimm R, McNeil J, Reid CM; ASPREE Investigator Group. Impact of the 2017 American Heart Association and American College of Cardiology hypertension guideline in aged individuals. J Hypertens. 2020 Dec;38(12):2527-2536, doi: 10.1097/HJH.0000000000002582. PMID: 32740404; PMCID: PMC8218338.
  • Ernst ME, Chowdhury EK, Beilin LJ, Margolis KL, Nelson MR, Wolfe R, Tonkin AM, Ryan J, Woods RL, McNeil JJ, Reid CR, for the ASPREE Investigator Group. Long-Term Blood Pressure Variability and Risk of Cardiovascular Disease Events Among Community-Dwelling Elderly. Hypertension, doi:10.1161/HYPERTENSIONAHA.120.16209 [published online 2020 Nov. 2].
  • Lockery JE, Ernst ME, Broder JC, Orchard SG, Murray A, Nelson MR, Stocks NP, Wolfe R, Reid CM, Liew D, Woods RL; ASPREE Investigator Group. Prescription Medication Use in Older Adults Without Major Cardiovascular Disease Enrolled in the Aspirin in Reducing Events in the Elderly (ASPREE) Clinical Trial. Pharmacotherapy 2020; Oct;40(10):1042-1053, doi:10.1002/phar.2461.
  • Robman LD, Thao LTP, Guymer RH, Wolfe R, Woods RL, Hodgson LAB, Phung J, Makeyeva GA, Le-Pham YA, Orchard SG, Suleiman J, Maguire E, Trevaks RE, Ward SA, Riaz M, Lacaze P, Elsdon S, Abhayaratna WP, Nelson MR, Ernst ME, Reid CM, McNeil JJ; ASPREE Investigator Group. Baseline characteristics and age-related macular degeneration in participants of the “ASPirin in Reducing Events in the Elderly” (ASPREE)-AMD trial. Contemporary Clinical Trials Communications 2020; 20: 100667,  doi:10.1016/jconctc.2020.100667 [published online 2020 Oct. 11].
  • Eisen DP, Leder K, Woods RL, Lockery JE, McGuinness SL, Wolfe R, Pilcher D, Moore EM, Shastry A, Nelson MR, Reid C, McNeil, JJ, McBryde ES. Effect of aspirin on deaths associated with sepsis in healthy older people (ANTISEPSIS): a randomised, double-blind, placebo-controlled primary prevention trial. The Lancet Respiratory Medicine 2020, doi.org/10.1016/S2213-2600(20)30411-2 [published online 2020 Sept. 17].
  • Gilmartin-Thomas JFM, Ernst ME, Nelson MR, Lockery JE, Ward SA, Woods RL, Britt C, Murray A, Workman B, McNeil JJ; ASPREE Investigator Group. Musculoskeletal Pain Experienced on Most Days is a Common Accompaniment of Ageing amongst Community-Dwelling Older Australians: A Questionnaire-Based Study. Journal of Aging and Health 2020, doi:10.1177/0898264320952914 [pre-print published online 2020 Sept. 11].
  • Wolfe R, Wetmore JB, Wood RL, McNeil JJ, Gallagher H, Roderick P, Walker R, Nelson MR, Reid CM, Shah RC, Ernst ME, Lockery JE, Tonkin AM, Abhayaratna WP, Gibbs P, Wood EM, Mahady SE, Williamson JD, Donnan GA, Cloud GC, Murray AM, Polkinghorne K, for the ASPREE Investigator Group. Subgroup analysis of the ASPirin in Reducing Events in the Elderly randomized clinical trial suggest aspirin did not improve outcomes in older adults with chronic kidney disease. Kidney International 2020, doi.org/10.1016/j.kint.2020.08.011  [published online 2020 Sept. 10].
  • Gilmartin-Thomas JFM, Cicuttini FM, Owen AJ, Wolfe R, Ernst ME, Nelson MR, Lockery J, Woods RL, Britt C, Liew D, Murray A, Workman B, Ward SA, McNeil JJ; ASPREE Investigator Group. Moderate or severe low back pain is associated with body mass index amongst community-dwelling older Australians. Arch Gerontol & Geriatrics 91; Nov-Dec 2020, 104231, doi:10.1016/j.archger.2020.104231 [published online 2020 Aug. 13].
  • McNeil JJ, Gibbs P, Orchard SG, Lockery JE, Bernstein WB, Cao Y, Ford L, Haydon A, Kirpach B, Macrae F, McLean C, Millar J, Murray AM, Nelson MR, Polekhina G, Reid CM, Richmond E, Rodríguez LM, Shah RC, Tie J, Umar A, van Londen GJ, Ronaldson K, Wolfe R, Woods RL, Zalcberg J, Chan A, for the ASPREE investigator Group. Effect of aspirin on cancer incidence and mortality in older adults. JNCI: Journal of the National Cancer Institute, djaa114, doi.org/10.1093/jnci/djaa114 [accepted manuscript published online 2020 Aug. 11].
  • Ryan J, Woods RL, Britt CJ, Murray AM, Shah RC, Reid CM, Wolfe R, Nelson MR, Orchard SG, Lockery JE, Trevaks RE, Storey E, for the ASPREE Investigator Group. Normative Data for the Symbol Digit Modalities Test in Older White Australians and Americans, African-Americans, and Hispanic/Latinos. J Alzheimer’s Disease Reports 2020;4: 313-23, doi: 10.3233/ADR-200194. [published online 2020 Aug. 04].
  • Mahady SE, Margolis KL, Chan A, Polekhina G, Woods RL, Wolfe R, Nelson MR, Lockery JE, Wood EM, Reid C, Ernst ME, Murray A, Thao LTP, McNeil JJ. Major GI bleeding in older persons using aspirin: incidence and risk factors in the ASPREE randomised controlled trial. Gut 2020, doi:10.1136/gutjnl-2020-321585 [published online 2020 Aug. 03].
  • Orchard SG, Lockery JE, Gibbs P, Polekhina G, Wolfe R, Zalcberg J, Haydon A, McNeil JJ, Nelson MR, Reid CM, Kirpach B, Murray AM, Woods RL, for the ASPREE investigator Group. Cancer history and risk factors in healthy older people enrolling in the ASPREE clinical trial. Contemporary Clinical Trials 2020; Sept. doi.org/10.1016/j.cct.2020.106095 [published online 2020 July 31].
  • Orchard ER, Ward PGD, Sforazzini F, Storey E, Egan G, Jamadar SD. Relationship between parenthood and cortical thickness in late adulthood. PLoS One 2020; 15(7):e0236031, doi:10.1371/journal.pone.0236031 [published online 2020 July 28].
  • Ward PDG, Orchard ER, Oldham S, Arnatkevičiūtė A, Sforazzini F, Fornito A, Storey E, Egan G, Jamadar SD. Individual differences in haemoglobin concentration influence bold fMRI functional connectivity and its correlation with cognition. NeuroImage 2020; 221:117196, doi:10.1016/j.neuroimage.2020.117196 [published online ahead of print 2020 July 25].
  • Ernst ME, Chowdhury EK, Nelson MR, Reid CM, Margolis KL, Beilin LJ, Stocks N, Murray AM, Wolfe R, Lockery JE, Orchard SG, Woods RL, McNeil JJ; the ASPREE Investigator Group. Antihypertensive medications use and blood pressure control among treated older adults. J Clin Hypertens. 2020; 00: 1– 9, doi.org/10.1111/jch.13934 [published online 2020 July 15].
  • Fransquet PD, Lacaze P. Saffery R, Phung J, Parker E, Shah R, Murray A, Woods RL, Ryan J. Blood DNA methylation signatures to detect dementia prior to overt clinical symptoms. Alzheimer’s & Dementia 2020; 12:e12056,  doi: 10.1002/dad2.12056 [published online 2020 July 7].
  • Davis SR, Garcia AM, Robinson PJ, Handelsman DJ, Desai R, Wolfe R, Bell RJ, the ASPREE Investigator Group, Estrone is a strong predictor of circulating estradiol in women aged 70 years and older, The Journal of Clinical Endocrinology & Metabolism, 2020; dgaa429, doi.org/10.1210/clinem/dgaa429 [accepted manuscript 2020 July 02].
  • Lacaze P, Sebra R, Riaz M, Tiller J, Revote J, Phung J, Parker EJ, Orchard SG, Lockery JE, Wolfe R, Strahl M, Wang YC, Chen R, Sisco D, Arnold T, Thompson BA, Buchanan DD, Macrae FA, James PA, Abhayaratna WP, Lockett TJ, Gibbs P, Tonkin AM, Nelson MR, Reid CM, Woods RL, Murray AM, Winship I, McNeil JJ, Schadt E. Medically actionable pathogenic variants in a population of 13,131 healthy elderly individuals. Genet Med. 2020; Nov;22(11):1883-1886, doi: 10.1038/s41436-020-0881-7 [epub 2020 July 1]. PMID: 32606442; PMCID: PMC7606791
  • Zhou Z, Ofori-Asenso R, Curtis A, Breslin M, Wolfe R, McNeil JJ, Murray AM, Ernst ME, Reid CM, Lockery JE, Woods RL, Tonkin AM, Nelson MR. Association of Statin Use with Disability-Free Survival and Cardiovascular Disease among Healthy Older Adults. J Amer Coll Cardiol. 2020; June 30; 76: 17-27, doi:10.1016/j.jacc.2020.05.016.
  • Lewis JP, Riaz M, Xie S, Polekhina G, Wolfe R, Nelson M, Tonkin AM, Reid CM, Murray AM, McNeil JJ, Shuldiner AR, Lacaze P. Genetic variation in PEAR1, cardiovascular outcomes and effects of aspirin in a healthy elderly population. Clin Pharmacol Ther. 2020, doi: 10.1002/cpt.1959 [online ahead of print 2020 June 20]. PMID: 32562573
  • Lacaze P, Sebra R, Riaz M, Hooper AJ, Tiller J, Bakshi A, Woods RL, Tonkin AM, Reid CM, Murray AM, Nicholls SJ, Watts GF, Schadt E, McNeil JJ. Familial Hypercholesterolemia in a Healthy Elderly Population. Circ Genom Precis Med. 2020; June 10, doi:10.1161/CIRCGEN.120.002938 [epub ahead of print].
  • Berk M, Woods RL, Nelson MR, Shah RC, Reid CM, Storey E, Fitzgerald S, Lockery JE, Wolfe, R, Mohebbi M, Dodd S, Murray AM, Stocks N, Fitzgerald P, Mazza C, Agustini B, McNeil JJ.  Effect of Aspirin vs Placebo on the Prevention of Depression in Older People: A Randomized Clinical Trial. JAMA Psychiatry 2020, doi:10.1001/jamapsychiatry.2020.1214 [published online 2020 June 03].
  • Agustini B, Lotfaliany M, Woods RL, McNeil JJ, Nelson MR, Shah RC, Murray AM, Ernst M, Reid CM, Tonkin A, Storey E, Lockery JE, Williams LJ, Berk M, Mohebbi M, on behalf of the ASPREE investigators. Patterns of association between depressive symptoms and chronic medical morbidities in older adults. J Amer Geriatrics Soc. 2020, doi 10.1111/jgs.16468. [published online 2020 May 13].
  • Woods RL, Polekhina G, Wolfe R, Nelson MR, Ernst ME, Reid CM, Shah RC, Lockery JE, Orchard SG, Murray AM, McNeil JJ, on behalf of the ASPREE Investigator Group. No modulation of aspirin’s effect by body weight in healthy older men and women. Circulation 2020; Mar. 30, doi.org/10.1161/CIRCULATIONAHA.119.044142.
  • Ryan J, Storey E, Murray AM, Woods RL, Wolfe R, Reid CM, Nelson MR, Chong T, Williamson JD, Ward SA, Lockery JE, Orchard SG, Trevaks R, Kirpach B, Newman AB, Ernst ME, McNeil JJ, Shah RC. Randomized Placebo-controlled Trial of the effects of Aspirin on Dementia and Cognitive Decline. Neurology 2020; Mar. 25, doi.org/10.1212/WNL.0000000000009277.
  • Barker AL, Soh SE, Sanders KM, Pasco J, Khosla S, Ebeling PR, Ward SA, Peeters G, Talevski J, Cumming RG, Seeman E, McNeil JJ. Aspirin and fracture risk: a systematic review and exploratory meta-analysis of observational studies. BMJ Open 2020; Feb. 20;10(2):e026876, doi: 10.1136/bmjopen-2018-026876.
  • Ryan J, Woods RL, Murray AM, Shah RC, Britt C, Reid CM, Wolfe R, Nelson MR, Lockery JE, Orchard SG, Trevaks R, Chong T, McNeil JJ, Storey E.  Normative Performance of Older Individuals on the Hopkins Verbal Learning Test-Revised (HVLT-R) According to Ethno-Racial Group, Gender, Age and Education Level. The Clinical Neuropsychologist 2020; Feb. 26, doi:10.1080/13854046.2020.1730444.
  • Agustini B, Mohebbi M, Woods RL, McNeil JJ, Nelson MR, Shah RC, Murray AM, Ernst ME, Reid CM, Tonkin A, Lockery JE, Berk M, on behalf of the ASPREE Investigator Group. The association of antihypertensive use and depressive symptoms in a large older population with hypertension living in Australia and the United States. Journal of Human Hypertension 2020; Pubmed 32001828,  doi.org/10.1038/s41371-020-0303-y.
  • Pinese M, Lacaze P, Rath E, Stone A, Brion MJ, Ameur A, Nagpal S, Puttick C, Husson S, Degrave D, Navin Cristina T, Kahl VS, Statham A, Woods R, McNeil J, Riaz M, Barr M, Nelson M, Reid C, Murray A, Shah R, Wolfe R, Atkins J, Fitzsimmons C, Cairns H, Green M, Carr V, Cowley M, Pickett H, James P, Powell J, Kaplan W, Gibson G, Gyllensten U, Cairns M, McNamara M, Dinger M, Thomas D. The Medical Genome Reference Bank contains whole genome and phenotype data of 2,570 healthy elderly. Nature Communications Online 2020; Jan. 23, doi:10.1038/s41467-019-14079-0.
  • Voskoboinik I, Lacaze P, Jang HS, Flinsenberg TWH, Fernando SL, Kerridge I, Riaz M, Sebra R, Thia KYT, Noori T, Schadt EE, McNeil JJ, Trapani JA. Prevalence and Disease Predisposition of p.A91V perforin in an aged Caucasian Population. Blood Journal 2020, doi:10.1182/blood-2019003487 [epub ahead of print 2020 Jan. 13].

2019

  • Lockery JE, Rigby J, Collyer TA, Stewart A, Woods RL, McNeil JJ, Reid CM, Ernst ME, on behalf of the ASPREE Investigator Group. Optimising medications data collection in a large-scale clinical trial. Plos One  2019; 14 (12), doi.org/10.1371/journal.pone.0226868.
  • Chowdhury EK, Nelson MR, Ernst ME, Margolis KL, Beilin LJ, Johnston CI, Woods RL, Murray AM, Wolfe R, Storey E, Shah RC, Lockery JE, Tonkin AM, Newman AB, Williamson JD, Abhayaratna WP, Stocks NP, Fitzgerald SM, Orchard SG, Trevaks RE, Donnan GA, Grimm R, McNeil JJ, Reid CM, for the ASPREE investigator Group. Factors associated with treatment and control of hypertension in a healthy elderly population free of cardiovascular disease: a cross-sectional study. American Journal of Hypertension 2019; Dec. 06, doi.org/10.1093/ajh/hpz192.
  • Jamadar SD, Sforazzini F, Raniga P, Ferris NJ, Paton B, Bailey MJ, Brodtmann A, Yates PA, Donnan GA, Ward SA, Woods RL, Storey E, McNeil JJ, Egan GF;  ASPREE Investigator Group. Sexual Dimorphism of Resting-State Network Connectivity in Healthy Ageing. The journals of gerontology. Series B, Psychological sciences and social sciences 2019; 74 (7): 1121-1131, doi:10.1093/geronb/gby004.
  • Lockery JE, Collyer TA, Reid CM, Ernst ME, Gilbertson D, Hay N, Kirpach B, McNeil JJ, Nelson MR, Orchard SG, Pruksawongsin K, Shah RC, Wolfe R, Woods RL, on behalf of the ASPREE Investigator Group. Overcoming challenges to data quality in the ASPREE clinical trial. Trials 2019; 20: 686, doi:10.1186/s13063-019-3789-2.
  • Davis SR, Bell RJ, Robinson PJ, Handelsman DJ, Gilbert T, Phung J, Desai R, Lockery JE, Woods RL, Wolfe RS, Reid CM, Nelson  MR, Murray AM, McNeil JJ. Testosterone and estrone increase from the age of 70 years; findings from the Sex Hormones in Older Women Study. J Clinical Endocrinology & Metabolism 2019; Aug. 13; pii: jc.2019-00743, doi: 10.1210/jc.2019-00743 [epub ahead of print].
  • Agustini B, Mohebbi M, Woods RL, McNeil JJ, Nelson MR, Shah RC, Murray AM, Ernst ME, Reid CM, Tonkin A, Lockery JE, Berk M; ASPREE Investigator Group. Association Between Statin Use and Depressive Symptoms in a Large Community-Dwelling Older Population Living in Australia and the USA: A Cross-Sectional Study. CNS Drugs 2019; May 6, doi: 10.1007/s40263-019-00633-3 [epub ahead of print].
  • Polkinghorne KR, Wolfe R, Jachno KM, Wetmore JB, Woods RL, McNeil JJ, Nelson MR, Reid CM, Murray AM; ASPREE Investigator Group. Prevalence of chronic kidney disease in the elderly using the ASPirin in Reducing Events in the Elderly study cohort. Nephrology 2019; 24:1248-1256, doi: 10.1111/nep.13565.
  • Mohebbi M, Agustini B, Woods RL, McNeil JJ, Nelson MR, Shah RC, Nguyen V, Storey E, Murray AM, Reid CM, Kirpach B, Wolfe RS, Lockery JE, Berk M; ASPREE Investigator Group. Prevalence of depressive symptoms and its associated factors among healthy community-dwelling older adults living in Australia and the United States. Int J Geriatr Psychiatry 2019; Apr. 16, doi: 10.1002/gps.5119 [epub ahead of print].
  • Lockery JE, Collyer TA, Abhayaratna WP, Fitzgerald SM, McNeil JJ, Nelson MR, Orchard SG, Reid C, Stocks NP, Trevaks RE, Woods RL. Recruiting general practice patients for large clinical trials: lessons from the Aspirin in Reducing Events in the Elderly (ASPREE) study. Med J Aust 2019; 210 (4): 168-173, doi: 10.5694/mja2.12060.
  • CORRESPONDENCE McNeil JJ, Woods RL, Murray AM, for the ASPREE Investigator Group. Effects of aspirin in the healthy elderly. Correspondence. N Engl J Med 2019; 380 (18): 1776-7, doi:10.1056/NEJMc1901774.
  • COMMENTARY Chan AT, McNeil J. Aspirin and Cancer Prevention in the Elderly: Where Do We Go From Here? Gastroenterology. 2019 Feb; 156(3):534-538, doi: 10.1053/j.gastro.2018.11.063.
  • McNeil JJ, Woods RL, Ward SA, Britt CJ, Lockery JE, Beilin LJ, Owen AJ. Cohort Profile: The ASPREE Longitudinal Study of Older Persons (ALSOP). International Journal of Epidemiology 2019, doi.org/10.1093/ije/dyy279.

2018

  • Lacaze P, Pinese M, Kaplan W, Stone A, Brion M, Woods RL, McNamara M, McNeil JJ, Dinger ME, Thomas DM. The Medical Genome Reference Bank: a whole-genome data resource of 4,000 healthy elderly individuals. Rationale and cohort design. European Journal of Human Genetics 2018, doi: 10.1038/s41431-018-0279-z.
  • Stocks N, González-Chica DA, Lockery JE, Shah RC, Murray AM, Wolfe R, Nelson MR, Reid CM, McNeil JJ, Woods RL, on behalf of the ASPREE Investigator Group. Quality of Life for 19,114 participants in the ASPREE (Aspirin in Reducing Events in the Elderly) Study and their association with sociodemographic and lifestyle modifiable risk factors. Quality of Life Research 2018, pp.1-12, doi: 10.1007/s11136-018-2040-z.
  • McNeil JJ*, Woods RL*, Nelson MR, Reid CM, Kirpach B, Wolfe R, Storey E, Shah RC, Lockery JE, Tonkin AM, Newman AB, Williamson JD, Margolis KL, Ernst ME, Abhayaratna WP, Stocks N, Fitzgerald SM, Orchard SG, Trevaks RE, Beilin LJ, Donnan GA, Gibbs P, Johnston CI, Ryan J, Radziszewska B, Grimm R & Murray AM, on behalf of the ASPREE Investigator Group (* joint first authors). Effect of aspirin on disability-free survival in the healthy elderly. New England Journal of Medicine 2018; 379:1499-1508, doi: 10.1056/nejmoa1800722 [published online Sept. 2018].
  • McNeil JJ*, Nelson MR*, Woods RL, Lockery JE, Wolfe R, Reid CM, Kirpach B, Shah RC, Ives DG, Storey E, Ryan J, Tonkin AM, Newman AB, Williamson JD, Margolis KL, Ernst ME, Abhayaratna WP, Stocks N, Fitzgerald SM, Orchard SG, Trevaks RE, Beilin LJ, Donnan GA, Gibbs P, Johnston CI, Radziszewska B, Grimm R & Murray AM, on behalf of the ASPREE Investigator Group (* joint first authors). Effect of aspirin on all-cause mortality in the healthy elderly. New England Journal of Medicine 2018; 379:1499-1508, doi: 10.1056/NEJMoa1803955 [published online Sept. 2018].
  • McNeil JJ, Wolfe R, Woods RL, Tonkin AM, Donnan GA, Nelson MR, Reid CM, Lockery JE, Kirpach B, Storey E, Shah RC, Williamson JD, Margolis KL, Ernst ME, Abhayaratna WP, Stocks N, Fitzgerald SM, Orchard SG, Trevaks RE, Beilin LJ, Johnston CI, Ryan J, Radziszewska B, Jelinek M, Malik M, Eaton C, Brauer D, Cloud G, Wood E, Mahady SE, Satterfield S, Grimm R & Murray AM, on behalf of the ASPREE Investigator Group. Effect of aspirin on cardiovascular events and bleeding in the healthy elderly. New England Journal of Medicine 2018; 379:1499-1508, doi: 10.1056/nejmoa1805819 [published online Sept. 2018].
  • Ryan J, Woods RL, Britt C, Murray AM, Shah RC, Reid CM, Kirpach B, Wolfe RS, Nelson MR, Lockery JE, Orchard SG, Trevaks RE, McNeil JJ, Storey E, on behalf of the ASPREE Investigator Group. Normative performance of healthy older individuals on the Modified Mini-Mental State (3MS) examination according to ethno-racial group, gender, age, and education level. The Clinical Neuropsychologist 2018, doi.org/10.1080/13854046.2018.1488996 [published online July 2018].
  • Margolis KL, Mahady SE, Nelson MR, Ives DG, Satterfield S, Britt C, Ekram S, Lockery JE, Schwartz EC, Woods RL, McNeil JJ, Wood EM. Development of a standardized definition for clinically significant bleeding in the ASPirin in Reducing Events in the Elderly (ASPREE) trial. Contemporary Clinical Trials Communications 2018; Vol 11, 30-36, doi.org/10.1016/j.conctc.2018.05.015.
  • Wolfe R, Murray AM, Woods, RL, Kirpach B, Gilbertson D, Shah RC, Nelson MR, Reid CM, Ernst ME, Lockery JE, Donnan GA, Williamson J, McNeil JJ. The aspirin in reducing events in the elderly trial: Statistical analysis plan. International Journal of Stroke 2018; Vol.13(3), pp.335-338, doi.org/10.1177/1747493017741383.
  • Fransquet PD, Lacaze P, Woods RL, McNeil JJ, Saffery R, Ryan J. Blood DNA methylation as a potential biomarker of dementia: a systematic review. Alzheimer’s & Dementia 2017; 14(1): 81-103. IF:11.0, doi: 10.1016/j.jalz.2017.10.002.
  • Ward SA, Storey E, Woods RL, Hamilton GS, Kawasaki R, Janke AL, Naughton MT, O’Donoghue F, Wolfe R, Wong TY, Reid CM, Abhayaratna WP, Stocks N, Trevaks R, Fitzgerald S, Hodgson LAB, Robman L, Workman B, Mcneil JJ. The Study of Neurocognitive Outcomes, Radiological and Retinal Effects of Aspirin in Sleep Apnoea- rationale and methodology of the SNORE-ASA study. Contemporary clinical trials 2018; Vol.64, pp.101-111, doi.org/10.1016/j.cct.2017.10.016.
  • Mohebbi M, Nguyen V, McNeil JJ, Woods RL, Nelson MR, Shah RC, Storey E, Murray AM, Reid CM, Kirpach B, Wolfe, R, Lockery JE, Berk M, on behalf of the ASPREE investigator group. Psychometric properties of a short form of the Center for Epidemiologic Studies Depression (CES-D-10) scale for screening depressive symptoms in healthy community dwelling older adults. General Hospital Psychiatry 2018; 51:118-125, doi: 10.1016/j.genhosppsych.2017.08.002.

2017-2015

  • McNeil JJ, Woods RL, Nelson MR, Murray AM, Reid CM, Kirpach B, Storey E, Shah RC, Wolfe R, Tonkin AM, Newman AB, Williamson JD, Lockery JE, Margolis KL, Ernst ME, Abhayaratna WP, Stocks N, Fitzgerald SM, Trevaks RE, Orchard SG, Beilin LJ, Donnan GA, Gibbs P, Johnston CI, Grimm RH, on behalf of the ASPREE investigator group. Baseline Characteristics of Participants in the ASPREE (ASPirin in Reducing Events in the Elderly) Study. J Gerontol A Biol Sci Med Sci 2017; Oct 12, Vol. 00, No. 00, 1–8, doi:10.1093/gerona/glw342.
  • Ward SA, Raniga P, Ferris NJ, Woods RL, Storey E, Bailey MJ, Brodtmann A, Yates PA, Donnan GA, Trevaks RE, Wolfe R, Egan GF, McNeil JJ; (Joint Senior authorship), on behalf of the ASPREE investigator group. ASPREE-NEURO study protocol: A randomized controlled trial to determine the effect of low-dose aspirin on cerebral microbleeds, white matter hyperintensities, cognition, and stroke in the healthy elderly. Int J Stroke 2017; 12(1):108-113, doi:10.1177/1747493016669848.
  • Lacaze P, Winship I, McNeil J. Penetrance and the Healthy Elderly. Genet Test Mol Biomarkers 2017; Nov 21(11):637-640, doi: 10.1089/gtmb.2017.0126 [epub 2017 Sept. 6].
  • Robman L, Guymer R, Woods RL, Ward SA, Wolfe R, Phung J, Hodgson L, Makeyeva G, Aung KZ, Gilbert T, Lockery JE, Le-Pham Y, Orchard S, Storey E, Abhayaratna W, Reid D, Ernst ME, Nelson MR, Reid C, McNeil, JJ. Age-related macular degeneration in a randomized controlled trial of low-dose aspirin: Rationale and study design of the ASPREE-AMD study. Contemporary Clinical Trials Communications 2017; Vol.6, pp.105-114, doi:10.1016/j.conctc.2017.03.005.
  • Lacaze P, Ryan J, Woods RL, Winship I, McNeil JJ. Pathogenic variants in the healthy elderly: unique ethical and practical challenges. Journal of Medical Ethics, 2017; Vol. 43(10), p.714, doi: 10.1136/medethics-2016-103967.
  • Lacaze P, Woods RL, Zoungas S, McNeil JJ. The genomic potential of the Aspirin in Reducing Events in the Elderly and Statins in Reducing Events in the Elderly studies. Internal medicine Journal 2017; Vol.47(4), pp.461-463, doi.org/10.1111/imj.13384.
  • Eisen DP, Moore EM, Leder K, Lockery JE, McBryde ES, McNeil JJ, Pilcher D, Wolfe R, Woods RL. AspiriN To Inhibit SEPSIS (ANTISEPSIS) randomised controlled trial protocol. BMJ Open 2017;7:e013636, doi: 10.1136/bmjopen-2016-013636.
  • Berk M, Woods RL, Nelson MR, Shah RC, Reid CM, Storey E, Fitzgerald SM, Lockery JE, Wolfe R, Mohebbi M, Murray AM, Kirpach B, Grimm R, McNeil JJ. ASPREE-D: Aspirin for the prevention of depression in the elderly. International Psychogeriatrics 2016, doi:10.1017/S104161021600079X.
  • Lowthian JA, Britt CJ, Rance G, Lin FR, Woods RL, Wolfe R, Nelson MR, Dillon HA, Ward S, Reid CM, Lockery JE, Nguyen TT, McNeil JJ, Storey E. Slowing the progression of age-related hearing loss: Rationale and study design of the ASPIRIN in HEARING, retinal vessels imaging and neurocognition in older generations (ASPREE-HEARING) trial. Contemp Clin Trials 2015; 46; 60-66, doi: 10.1016/j.cct.2015.11.014.
  • Barker AL, McNeil JJ, Seeman E, Ward SA, Sanders KM, Khosla S, Cumming RG, Pasco JA, Bohensky MA, Ebeling PR, Woods RL, Lockery JE, Wolfe R, Talevski J, and the ASPREE Investigator Group. A randomised controlled trial of low-dose aspirin for the prevention of fractures in healthy older people: protocol for the ASPREE-Fracture substudy. Inj Prev. 2015; pii: injuryprev-2015-041655, doi: 10.1136/injuryprev-2015-041655 [epub ahead of print]. PMID: 26002770

2014-2010

  • COMMENTARY Chong EW, Guymer RH, Robman LD. Does aspirin increase the risk of age-related macular degeneration? Expert Opinion on Drug Safety 2014; 13:691-3, doi: 10.1517/14740338.2014.914169.
  • ASPREE Investigator Group. Study design of ASPirin in Reducing Events in the Elderly (ASPREE): a randomized, controlled trial. Contemporary Clinical Trials 2013; 36: 555–564, doi: org/10.1016%2Fj.cct.2013.09.014.
  • COMMENTARY Nelson MR. General practice-based clinical trials. Perspectives, Med J Aust 2013; 198 (3), doi: 10.5694/mja12.11061.
  • Reid CM, Storey E, Wong TY, Woods RL, Tonkin A, Wang JJ, Kam A, Janke A, Essex R, Abhayaratna WP, Budge MM, on behalf of the ASPREE Study Group. Aspirin for the prevention of cognitive decline in the elderly: rationale and design of a neuro-vascular imaging study (ENVIS-ion). BMC Neurol. 2012; 12:3, doi: 10.1186/1471-2377-12-3.
  • Linden MD, Tran HA, Woods RL, Tonkin AM. High platelet reactivity and antiplatelet therapy resistance. Seminars in Thrombosis and Hemostasis 2012; 38(2):200-12, doi: 10.1055/s-0032-1301417.
  • Ward SA, Demos L, Workman B, McNeil JJ. Aspirin for primary prevention of cardiovascular events in the elderly: current status and future directions. Drugs Aging 2012; Apr. 1;29(4):251-8, doi.org/10.2165/11599030-000000000-00000.

2009-1990

  • EDITORIAL Woods RL, Tonkin AM, Nelson MR, Britt HC, Reid CM. Should aspirin be used for the primary prevention of cardiovascular disease in people with diabetes? Med J Aust. 2009; 190:614-5 PMID:19485837
  • Nelson MR, Reid CM, Ames DA, Beilin LJ, Donnan GA, Gibbs P, Johnston CI, Krum H, Storey E, Tonkin A, Wolfe R, Woods R, McNeil JJ. Feasibility of conducting a primary prevention trial of low-dose aspirin for major adverse cardiovascular events in older people in Australia: results from the ASPirin in Reducing Events in the Elderly (ASPREE) pilot study. Med J Aust. 2008; 189:105-109, doi.org/10.5694/j.1326-5377.2008.tb01932.x.  PMID:18637782
  • Nelson MR, Liew D, Bertram M, Vos T. Epidemiological modelling of routine use of low-dose aspirin in Australia for the primary prevention of coronary heart disease and stroke in those aged 70 years and above. BMJ 2005; 330:1306-1308, doi: 10.1136/bmj.38456.676806.8F.
  • CONFERENCE PROCEEDINGS Nelson MR, Reid CM, Johnstone CI, Krum H, Storey E, Tonkin A, Beilin LJ, Donnan GA, McNeil JJ.  After ANBP2 – ASPREE  Clinical And Experimental Pharmacology And Physiology, Melbourne, Australia 2003; Vol.30(7), pp.A59-A59.
  • ASPREE Study Group. Nelson MR, Reid CM, Beilin LJ, Donnan GA, Johnston CI, Krum H, Storey E, Tonkin AM, McNeil JJ.  Rationale for a primary prevention trial in the elderly of low dose aspirin for the prevention of major adverse cardiovascular events and vascular dementia in Australian general practice.  ASPirin in Reducing Events in the Elderly (ASPREE). J Drugs and Aging 2003; 20(12):897-903, doi: 10.2165/00002512-200320120-00004.
  • Silagy CA, McNeil JJ, Donnan GA, Tonkin AM, Worsam B, Campion K. The PACE pilot study: 12-month results and implications for future primary prevention trials in the elderly. (Prevention with low-dose Aspirin of Cardiovascular disease in the Elderly). J Am Geriatr Soc. 1994; 42(6):643-64, doi.org/10.1111/j.1532-5415.1994.tb06864.x.
  • Silagy CA, McNeil JJ, Donnan GA, Tonkin AM, Worsam B, Campion K. Adverse effects of low-dose aspirin in a healthy elderly population. Clin Pharmacol Ther, 1993; 54(1):84-89, doi:10.1038/clpt.1993.115.
  • Silagy CA, McNeil JJ, Bulpitt CJ, Donnan GA, Tonkin AM, Worsam B. Rationale for a primary prevention study using low-dose aspirin to prevent coronary and cerebrovascular disease in the elderly. J Am Geriatr Soc. 1991; 39(5):484-491, doi.org/10.1111/j.1532-5415.1991.tb02494.x.
  • Campion K, Silagy CA, McNeil JJ, Donnan GA, Tonkin AM, Worsam B. Comparison of recruitment strategies for a large-scale multicentred clinical trial in the elderly. Community Health Stud, 1990; 14(4):400, doi: 10.1016/0895-4356(91)90013-y.
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