• ASPREE USA
Aspree USA
Aspree USA
Studying the effect of Aspirin on healthy lifespan

ASPirin in Reducing Events in the Elderly

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We’ve published major new aspirin findings thanks to the generosity of older people living in south-eastern Australia and the USA.

Important Information for participants about ASPREE-XT Study Visits and the Coronavirus (COVID-19). Click here to read

ASPIRIN and HEALTH

Based on quality evidence, doctors prescribe daily low-dose aspirin to people who have had a heart attack or stroke to help prevent that event from reoccurring. This is known as ‘secondary prevention’.  ASPREE was a clinical trial to determine whether aspirin helped older people to live well for longer by delaying the onset of illnesses in the first place (called ‘primary prevention’) and if the benefits outweighed potential adverse effects of aspirin, such as bleeding.

ASPREE and the follow up ASPREE-XT study, will determine for the first time, aspirin’s short term and longer term effects in healthy older people.

THE ASPREE (ASPirin in Reducing Events in the Elderly) STUDY:

March 2010 – January 2018

ASPREE was an international clinical trial to determine whether daily low-dose aspirin increased survival, free of dementia or physical disability for healthy older people. The ‘gold standard’ trial – randomised, double blind, placebo-controlled trial – was the first to investigate aspirin’s benefit versus risk in healthy older people without a history of cardiovascular disease, dementia or significant physical disability.
In 2018, the bi-national trial found that over an average of 4.7 years, aspirin did not prolong life free of persistent physical disability or dementia (disability free survival) in 19,114 healthy community dwelling people, most aged 70 years or older. Aspirin did not significantly reduce the risk of heart attacks or strokes, but the risk of serious bleeding among the aspirin takers was increased compared to the placebo group.
The main ASPREE study results were published in the New England Journal of Medicine in September 2018. These findings, for the first time provided clinicians with scientific evidence of the benefits and risks of aspirin for disease prevention in healthy older people. Read the National Institute on Aging (NIA) announcement of the main ASPREE study results. Download Q&As about ASPREE study findings here.

ASPREE was led by Berman Center for Outcomes and Clinical Research – Hennepin Healthcare Research Institute and Monash University in Australia. The study was undertaken across more than 30 hubs in the US.

More results from ASPREE are expected to be published this year.

THE ASPREE-XT (eXTension) STUDY:

January 2018 – 2024

ASPREE-XT (eXTension) is a follow up study in ASPREE participants to determine whether those in the aspirin group, compared to the placebo group, have different health outcomes such as for cancer, dementia, frailty and other conditions of ageing, over the longer term. The longer term effect of aspirin on health needs to be studied further because diseases such as cancer and dementia develop over an extended period of time and may not have been apparent during the ASPREE trial.

ASPREE-XT will determine factors, such as those related to lifestyle, health behaviour, environment, genes, blood biomarkers and many others, that may be predictors of good health and longevity or predispose to age-related diseases.

ASPREE-XT is led by the Berman Center for Outcomes and Clinical Research – Hennepin Healthcare Research Institute in the US and Monash University in Australia and is undertaken in the community in the US and across south-eastern Australia. 

 

Funding
  • NIH - National Institutes of Health (USA)
  • NHMRC - National Health & Medical Research Council (Australia)
  • NIA - National Institute on Aging (NIH) 
  • NCI - National Cancer Institute (NIH)
  • VCA - Victorian Cancer Agency (Australia)
  • CSIRO - Commonwealth Scientific and Industrial Research Organisation (Australia)
  • Monash University (Australia)

Collaborators
  • USA
  • Minneapolis Medical Research Foundation (Berman Center) 
  • University of Pittsburgh 
  • Rush University Medical Center
  • University of Texas
  • Wake Forest University
  • University of San Antonio

  • Australia
  • Monash University
  • Menzies Institute for Medical Research
  • Australian National University
  • University of Melbourne
  • University of Adelaide
Recent News
  • ASPREE-XT study visits conducted by phone during COVID-19 outbreak
    03/25/2020
  • ASPREE-XT (eXTension) study funded to determine longer-term effects of aspirin on health
    08/01/2019
  • ASPREE Study Findings Published
    10/12/2018
  • Lack of Evidence Excludes Elderly in US Draft Aspirin Policy
    09/16/2015

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