Study of aspirin and anemia risk in healthy older adults


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ASPREE results summary


Aspirin and Aging Health Research

Populations around the world are aging. The ASPREE project is a long-term multi-center, bi-national study of aspirin and health in older adults, with the purpose to discover ways to maintain health, quality of life and independence as we age.

This landmark research has two components:

1) ASPREE (ASPirin in Reducing Events in the Elderly), a randomised, blinded, placebo-controlled clinical trial of low-dose (100mg) aspirin in healthy older adults. The trial’s ground-breaking findings underpin revised international aspirin prescribing guidelines.

2) ASPREE-XT (ASPREE – eXTension) study, an ongoing, follow-up observational health study to investigate long-lasting effects of low-dose aspirin on disease, such as cancer. Additionally, it investigates a broad range of factors that contribute to the maintenance of physical and cognitive health in older adults.

Findings from the ASPREE project advance the care and wellbeing of aging adults around the world.


key facts


ASPREE Participants

All participants – 2,411 in the U.S., aged 70+ years (minorities aged 65+ years) and 16,703 in Australia –  were free of dementia, significant physical disability and known cardiovascular disease at enrollment.


Public funded

The ASPREE Project is funded by the United States and Australian governments and is led by the Berman Centre for Outcomes and Clinical Research in the U.S. and Monash University in Australia.

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Sub-studies in USA & AUS

Thanks to the support of participants during the ASPREE project, multiple sub-studies have provided and will continue to provide, invaluable information on aspects of health and aging.


ASPREE Trial Results

In September 2018, the ASPREE trial published results in three separate papers in one edition of the prestigious New England Journal of Medicine.

Translation into Care

The American College of Cardiology and American Heart Association adopted ASPREE findings into their revised primary prevention aspirin guidelines.


ASPREE-XT is an important follow up study into demographic, health, genomic and environmental factors that contribute to healthy aging.

Page updated:  August 14, 2023