ASPREE-XT Microbiome

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ASPREE results summary


Aspirin and Ageing Health Research

Populations around the world are ageing. The ASPREE project is a long-term multi-centre, bi-national study of aspirin and health in older adults, with the purpose to discover ways to maintain health, quality of life and independence as we age.

This landmark research has two components:

1) ASPREE (ASPirin in Reducing Events in the Elderly), a randomised, blinded, placebo-controlled clinical trial of low-dose (100mg) aspirin in healthy older adults. The trial’s ground-breaking findings underpin revised international aspirin prescribing guidelines.

2) ASPREE-XT (ASPREE – eXTension) study, an ongoing, follow-up observational health study to investigate long-lasting effects of low-dose aspirin on disease, such as cancer. Additionally, it investigates a broad range of factors that contribute to the maintenance of physical and cognitive health in older adults.

Findings from the ASPREE project advance the care and wellbeing of ageing adults around the world.


key facts


ASPREE Participants 

All participants – 16,703 in Australia (aged 70+ years) and 2,411 in the U.S. (minorities aged 65+ years) –  were free of dementia, significant physical disability and known cardiovascular disease at enrolment.


Public funded 

The ASPREE Project is funded by the Australian and U.S. governments and is led by Monash University in Australia and the Berman Centre for Outcomes and Clinical Research in the United States.

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Specialty sub-studies

Thanks to the support of participants during the ASPREE project, multiple sub-studies have provided and will continue to provide, invaluable information on aspects of health and ageing.


ASPREE Trial Results

In September 2018, the ASPREE trial published results in three separate papers in one edition of the prestigious New England Journal of Medicine.

Translation into Care

The American College of Cardiology and American Heart Association adopted ASPREE findings into their revised primary prevention aspirin guidelines.

ASPREE-XT Commences

ASPREE-XT is an important follow up study into demographic, health, genomic and environmental factors that contribute to healthy ageing.

Page updated: 1 March 2021


ASPREE-XT Microbiome Sub-Study Begins!
ASPREE-XT Microbiome Sub-Study Begins!

ASPREE-XT participants are invited to enrol in the new ASPREE-XT microbiome sub-study, which examines the role trillions of bacteria, viruses, fungi and other microbes in the gut (the microbiome) has on ageing health.