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ASPREE results summary
THE ASPREE PROJECT
Aspirin and Ageing Health Research
Populations around the world are ageing. The ASPREE project is a long-term multi-centre, bi-national study of aspirin and health in older adults, with the purpose to discover ways to maintain health, quality of life and independence as we age.
This landmark research has two components:
1) ASPREE (ASPirin in Reducing Events in the Elderly), a randomised, blinded, placebo-controlled clinical trial of low-dose (100mg) aspirin in healthy older adults. The trial’s ground-breaking findings underpin revised international aspirin prescribing guidelines.
2) ASPREE-XT (ASPREE – eXTension) study, an ongoing, follow-up observational health study to investigate long-lasting effects of low-dose aspirin on disease, such as cancer. Additionally, it investigates a broad range of factors that contribute to the maintenance of physical and cognitive health in older adults.
Findings from the ASPREE project advance the care and wellbeing of ageing adults around the world.
All participants – 16,703 in Australia (aged 70+ years) and 2,411 in the U.S. (minorities aged 65+ years) – were free of dementia, significant physical disability and known cardiovascular disease at enrolment.
The ASPREE Project is funded by the Australian and U.S. governments and is led by Monash University in Australia and the Berman Centre for Outcomes and Clinical Research in the United States.
Thanks to the support of participants during the ASPREE project, multiple sub-studies have provided and will continue to provide, invaluable information on aspects of health and ageing.
ASPREE Trial Results
In September 2018, the ASPREE trial published results in three separate papers in one edition of the prestigious New England Journal of Medicine.
Translation into Care
The American College of Cardiology and American Heart Association adopted ASPREE findings into their revised primary prevention aspirin guidelines.
ASPREE-XT is an important follow up study into demographic, health, genomic and environmental factors that contribute to healthy ageing.
Page updated: 1 March 2021
A sub-analysis of ASPREE data found that moderate drinking of alcohol is associated with a reduced risk of cardiovascular disease and a lowering of mortality from all causes – when compared to zero alcohol consumption. Researchers say findings should be interpreted with caution.
ASPREE-XT participants are invited to enrol in the new ASPREE-XT microbiome sub-study, which examines the role trillions of bacteria, viruses, fungi and other microbes in the gut (the microbiome) has on ageing health.
New analysis of ASPREE data reveals high long term blood pressure variability (BPV) in older adults, particularly men, is associated with an increased risk of dementia and cognitive decline