ASPREE PUBLICATIONS

ASPREE published papers

2021

• Neumann JT, Riaz M, Bakshi A, Polekhina G, Thao LTP, Nelson MR, Woods RL, Abraham G, Inouye M, Reid CM, Tonkin AM, Williamson JD, Donnan G, Brodtmann A, Cloud GC, McNeil JJ, Lacaze P. Predictive performance of a polygenic risk score for incident ischemic stroke in a healthy older population. Stroke 2021; 52, doi:10.1161/STROKEAHA.120.033670 [epub ahead of print, May 27].
• Riaz M, Huq A, Ryan J, Orchard SG, Tiller J, Lockery J, Woods RL, Wolfe R, Renton AE, Goate AM, Sebra R, Schadt E, Brodtmann A, Shah RC, Storey E, Murray AM, McNeil JJ, Lacaze P. Effect of APOE and a polygenic risk score on incident dementia and cognitive decline in a healthy older population. Aging Cell. 2021, doi: 10.1111/acel.13384. [epub ahead of print, May 26] PMID: 34041846.
• Nunn JS, Sulovski M, Tiller J, Holloway B, Ayton D, Lacaze P. Involving elderly research participants in the co-design of a future multi-generational cohort study. Research Involvement and Engagement 7:23. 2021 May 3, doi.org/10.1186/s40900-021-00271-4
• Wu Z, Woods RL, Wolfe R, Storey E, Chong TTJ, Shah RC, Orchard SG, McNeil JJ, Murray AM, Ryan J; the ASPREE Investigator Group. Trajectories of cognitive function in community‐dwelling older adults: A longitudinal study of population heterogeneity. Alzheimer’s Dement. 2021 May 2. doi.org/10.1002/dad2.12180
• Bakshi A, Yan M, Riaz M, Polekhina G, Orchard SG, Tiller J, Wolfe R, Joshi A, Cao Y, McInerney-Leo AM, Yanes T, Janda M, Soyer HP, Cust AE, Law MH, Gibbs P, McLean C, Chan AT, McNeil JJ, Mar VJ, Lacaze P. Genomic Risk Score for Melanoma in a Prospective Study of Older Individuals. J Natl Cancer Inst. 2021, doi: 10.1093/jnci/djab076 [epub ahead of print, 2021 April 10].
• Lockery JE, Broder JC, Ryan J, Stewart AC, Woods RL, Chong TT, Cloud GC, Murray A, Rigby JD, Shah R, Storey E, Ward SA, Wolfe R, Reid CM, Collyer TA, Ernst ME; ASPREE Investigator Group listed on www.aspree.org. A Cohort Study of Anticholinergic Medication Burden and Incident Dementia and Stroke in Older Adults. J Gen Intern Med. 2021, doi: 10.1007/s11606-020-06550-2 [Epub ahead of print Mar. 22] PMID: 33754317.
• Phyo AZZ, Gonzalez-Chica DA, Stocks NP, Storey E, Woods RL, Murray AM, Orchard SG, Shah RC, Gasevic D, Freak-Poli R, Ryan J; ASPREE Investigator Group. The Utility of Assessing Health-Related Quality of Life to Predict Cognitive Decline and Dementia. J Alzheimers Dis. doi: 10.3233/JAD-201349 [Epub ahead of print 2021 Feb. 12] PMID: 33579847.
• EDITORIAL McNeil JJ, Aspirin and primary prevention of colorectal cancer: a still evolving story, JNCI: Journal of the National Cancer Institute, 2021;djab010, doi.org/10.1093/jnci/djab010 [Published online, 2021 Feb 02].
• Berk M, Agustini B, Woods RL, Nelson MR, Shah RC, Reid CM, Storey E, Fitzgerald S, Lockery JE, Wolfe R, Mohebbi M, Dodd S, Murray AM, Stocks N, Fitzgerald P, Mazza C, McNeil JJ. Effects of aspirin on the long-term management of depression in older people: a double-blind randomised placebo-controlled trial. Mol Psychiatry 2021,  doi.org/10.1038/s41380-021-01020-5 [Published online, 2021 Jan. 27].
• Phyo A, Ryan J, Gonzalez-Chica DA, Woods RL, Reid CM, Nelson MR, Murray AM, Gasevic D, Stocks NP, Freak-Poli R; the ASPREE Investigator Group. Health-related quality of life and all-cause mortality among older health individuals in Australia and the United States: a prospective cohort study. Quality of Life Research 2021;30(4):1037-48. doi:10.1007/s11136-020-02723-y [Published online, 2021 Jan. 03].

2020

• Woods RL, Espinoza S, Thao LTP, Ernst ME, Ryan J, Wolfe R, Shah RC, Ward SA, Storey E, Nelson MR, Reid CM, Lockery JE, Orchard SG, Trevaks RE, Fitzgerald SM, Stocks NP, Williamson JD, McNeil JJ, Murray AM, Newman AB; ASPREE Investigator Group. Effect of Aspirin on Activities of Daily Living Disability in Community-Dwelling Older Adults. J Gerontol A Biol Sci Med Sci. 2020;glaa316. doi:10.1093/gerona/glaa316 [Published online ahead of print, 2020 Dec 26].
• Islam RM, Bell RJ, Handelsman DJ, Robinson PJ, Wolfe R, Davis SR; ASPREE Investigator Group. Longitudinal changes over three years in sex steroid hormone levels in women aged 70 years and over. Clin Endocrinol (Oxf). 2020 Dec 22. doi: 10.1111/cen.14401 [Epub ahead of print] PMID: 33351205.
• Lefevre A, Hopper I, McNeil JJ, Owen A; ALSOP Complementary Medicine Research Group. Complementary medicine use by community-dwelling older Australians. Med J Aust. 2020;10.5694/mja2.50884. doi:10.5694/mja2.50884 [Published online ahead of print, 2020 Dec 10].
• Gilmartin-Thomas JF, Forbes A, Liew D, McNeil JJ, Cicuttini FM, Owen AJ, Ernst ME, Nelson MR, Lockery J, Ward SA, Busija L; ASPREE Investigator Group. Evaluation of the Pain Impact Index for community-dwelling older adults through the application of Rasch modelling. Pain Pract. 2020 Dec 9. doi: 10.1111/papr.12980 [Epub ahead of print] PMID: 33295122.
• Ernst ME, Chowdhury EK, Beilin LJ, Margolis KL, Nelson MR, Wolfe R, Tonkin AM, Ryan J, Woods RL, McNeil JJ, Reid CR, for the ASPREE Investigator Group. Long-Term Blood Pressure Variability and Risk of Cardiovascular Disease Events Among Community-Dwelling Elderly. Hypertension. Published online November 2 doi10.1161/HYPERTENSIONAHA.120.16209.
• Lockery JE, Ernst ME, Broder JC, Orchard SG, Murray A, Nelson MR, Stocks NP, Wolfe R, Reid CM, Liew D, Woods RL; ASPREE Investigator Group. Prescription Medication Use in Older Adults Without Major Cardiovascular Disease Enrolled in the Aspirin in Reducing Events in the Elderly (ASPREE) Clinical Trial. Pharmacotherapy. 2020 Oct;40(10):1042-1053, published online October 20 doi: 10.1002/phar.2461.
• Robman LD, Thao LTP, Guymer RH, Wolfe R, Woods RL, Hodgson LAB, Phung J, Makeyeva GA, Le-Pham YA, Orchard SG, Suleiman J, Maguire E, Trevaks RE, Ward SA, Riaz M, Lacaze P, Elsdon S, Abhayaratna WP, Nelson MR, Ernst ME, Reid CM, McNeil JJ, ASPREE Investigator Group. Baseline characteristics and age-related macular degeneration in participants of the “ASPirin in Reducing Events in the Elderly” (ASPREE)-AMD trial. Contemporary Clinical Trials Communications 2020; 20: 100667, published online October 11 doi:10.1016/jconctc.2020.100667 
• Eisen DP, Leder K, Woods RL, Lockery JE, McGuinness SL, Wolfe R, Pilcher D, Moore EM, Shastry A, Nelson MR, Reid C, McNeil, JJ, McBryde ES. Effect of aspirin on deaths associated with sepsis in healthy older people (ANTISEPSIS): a randomised, double-blind, placebo-controlled primary prevention trial. The Lancet Respiratory Medicine. 2020. Published online September 17 doi.org/10.1016/S2213-2600(20)30411-2
• Gilmartin-Thomas JFM, Ernst ME, Nelson MR, Lockery JE, Ward SA, Woods RL, Britt C, Murray A, Workman B, McNeil JJ, ASPREE Investigator Group. Musculoskeletal Pain Experienced on Most Days is a Common Accompaniment of Ageing amongst Community-Dwelling Older Australians: A Questionnaire-Based Study. Journal of Aging and Health. September 2020. Pre-print published online 2020 September 11 doi:10.1177/0898264320952914.
• Wolfe R, Wetmore JB, Wood RL, McNeil JJ, Gallagher H, Roderick P, Walker R, Nelson MR, Reid CM, Shah RC, Ernst ME, Lockery JE, Tonkin AM, Abhayaratna WP, Gibbs P, Wood EM, Mahady SE, Williamson JD, Donnan GA, Cloud GC, Murray AM, Polkinghorne K, for the ASPREE Investigator Group. Subgroup analysis of the ASPirin in Reducing Events in the Elderly randomized clinical trial suggest aspirin did not improve outcomes in older adults with chronic kidney disease. Kidney International. 2020.  Published online September 10 doi.org/10.1016/j.kint.2020.08.011.
• Gilmartin-Thomas JFM, Cicuttini FM, Owen AJ, Wolfe R, Ernst ME, Nelson MR, Lockery J, Woods RL, Britt C, Liew D, Murray A, Workman B, Ward SA, McNeil JJ, ASPREE Investigator Group. Moderate or severe low back pain is associated with body mass index amongst community-dwelling older Australians. Arch Gerontol & Geriatrics 91; Nov-Dec 2020, 104231.Published online 2020 August 13 doi:10.1016/j.archger.2020.104231.
• McNeil JJ, Gibbs P, Orchard SG, Lockery JE, Bernstein WB, Cao Y, Ford L, Haydon A, Kirpach B, Macrae F, McLean C, Millar J, Murray AM, Nelson MR, Polekhina G, Reid CM, Richmond E, Rodríguez LM, Shah RC, Tie J, Umar A, van Londen GJ, Ronaldson K, Wolfe R, Woods RL, Zalcberg J, Chan A, for the ASPREE investigator Group. Effect of aspirin on cancer incidence and mortality in older adults. JNCI: Journal of the National Cancer Institute, djaa114,  Accepted manuscript published online 2020 August 11 doi.org/10.1093/jnci/djaa114.
• Ryan J, Woods RL, Britt CJ, Murray AM, Shah RC, Reid CM, Wolfe R, Nelson MR, Orchard SG, Lockery JE, Trevaks RE, Storey E for the ASPREE Investigator Group. Normative Data for the Symbol Digit Modalities Test in Older White Australians and Americans, African-Americans, and Hispanic/Latinos. J Alzheimer’s Disease Reports 2020;4: 313-23.  Published online 2020 August 04 doi: 10.3233/ADR-200194.
• Mahady SE, Margolis KL, Chan A, Polekhina G, Woods RL, Wolfe R, Nelson MR, Lockery JE, Wood EM, Reid C, Ernst ME, Murray A, Thao LTP, McNeil JJ. Major GI bleeding in older persons using aspirin: incidence and risk factors in the ASPREE randomised controlled trial. Gut August 2020. . Published online 2020 August 03 doi:10.1136/gutjnl-2020-321585.
• Orchard SG, Lockery JE, Gibbs P, Polekhina G, Wolfe R, Zalcberg J, Haydon A, McNeil JJ, Nelson MR, Reid CM, Kirpach B, Murray AM, Woods RL for the ASPREE investigator Group. Cancer history and risk factors in healthy older people enrolling in the ASPREE clinical trial. Contemporary Clinical Trials 2020 Sept. Published online 2020 July 31.doi.org/10.1016/j.cct.2020.106095.
• Orchard ER, Ward PGD, Sforazzini F, Storey E, Egan G, Jamadar SD. Relationship between parenthood and cortical thickness in late adulthood. PLoS One 2020;15(7):e0236031. e0236031. 2020 July 28 doi:10.1371/journal.pone.0236031.
• Ward PDG, Orchard ER, Oldham S, Arnatkevičiūtė A, Sforazzini F, Fornito A, Storey E, Egan G, Jamadar SD. Individual differences in haemoglobin concentration influence bold fMRI functional connectivity and its correlation with cognition. NeuroImage 2020;221:117196. Published online ahead of print 2020 July 25 doi:10.1016/j.neuroimage.2020.117196.
• Ernst ME, Chowdhury EK, Nelson MR, Reid CM, Margolis KL, Beilin LJ, Stocks N, Murray AM, Wolfe R, Lockery JE, Orchard SG, Woods RL, McNeil JJ; the ASPREE Investigator Group. Antihypertensive medication use and blood pressure control among treated older adults. J Clin Hypertens. 2020; 00: 1– 9. Published online 2020 July 15 doi.org/10.1111/jch.13934.
• Fransquet PD, Lacaze P. Saffery R, Phung J, Parker E, Shah R, Murray A, Woods RL, Ryan J. Blood DNA methylation signatures to detect dementia prior to overt clinical symptoms. Alzheimer’s & Dementia 2020; 12:e12056. Published online 2020 July 7 doi: 10.1002/dad2.12056.
• Davis SR, Garcia AM, Robinson PJ, Handelsman DJ, Desai R, Wolfe R, Bell RJ On behalf of the ASPREE Investigator Group, Estrone is a strong predictor of circulating estradiol in women aged 70 years and older, The Journal of Clinical Endocrinology & Metabolism, dgaa429, 2020. Accepted manuscript 2020 July 02 doi.org/10.1210/clinem/dgaa429.
• Lacaze P, Sebra R, Riaz M, Tiller J, Revote J, Phung J, Parker EJ, Orchard SG, Lockery JE, Wolfe R, Strahl M, Wang YC, Chen R, Sisco D, Arnold T, Thompson BA, Buchanan DD, Macrae FA, James PA, Abhayaratna WP, Lockett TJ, Gibbs P, Tonkin AM, Nelson MR, Reid CM, Woods RL, Murray AM, Winship I, McNeil JJ, Schadt E. Medically actionable pathogenic variants in a population of 13,131 health elderly individuals. Genet Med 2020. Published online 2020 July 01 doi:10.1038/s41436-020-0881-7.
• Zhou Z, Ofori-Asenso R, Curtis A, Breslin M, Wolfe R, McNeil JJ, Murray AM, Ernst ME, Reid CM, Lockery JE, Woods RL, Tonkin AM, Nelson MR. Association of Statin Use with Disability-Free Survival and Cardiovascular Disease among Healthy Older Adults. J Amer Coll Cardiol 2020 Jun 30; 76: 17-27 doi:10.1016/j.jacc.2020.05.016.
• Lewis JP, Riaz M, Xie S, Polekhina G, Wolfe R, Nelson M, Tonkin AM, Reid CM, Murray AM, McNeil JJ, Shuldiner AR, Lacaze P. Genetic variation in PEAR1, cardiovascular outcomes and effects of aspirin in a healthy elderly population. Clin Pharmacol Ther. 2020 Jun 20. PMID: 32562573 online ahead of print doi: 10.1002/cpt.1959.
• Lacaze P, Sebra R, Riaz M, Hooper AJ, Tiller J, Bakshi A, Woods RL, Tonkin AM, Reid CM, Murray AM, Nicholls SJ, Watts GF, Schadt E, McNeil JJ. Familial Hypercholesterolemia in a Healthy Elderly Population. Circ Genom Precis Med. 2020 Jun 10.  Epub ahead of print doi:10.1161/CIRCGEN.120.002938.
• Berk M, Woods RL, Nelson MR, Shah RC, Reid CM, Storey E, Fitzgerald S, Lockery JE, Wolfe R, Mohebbi M, Dodd S, Murray AM, Stocks N, Fitzgerald P, Mazza C, Agustini B, McNeil JJ,  Effect of Aspirin vs Placebo on the Prevention of Depression in Older People: A Randomized Clinical Trial . JAMA Psychiatry. Published online 2020 June 03 doi:10.1001/jamapsychiatry.2020.1214.
• Agustini B, Lotfaliany M, Woods RL, McNeil JJ, Nelson MR, Shah RC, Murray AM, Enst M, Reid CM, Tonkin A, Storey E, Lockery JE, Williams LJ, Berk M, Mohebbi M, on behalf of the ASPREE investigators. Patterns of association between depressive symptoms and chronic medical morbidities in older adults. J Amer Geriatrics Soc. Published online 2020 May 13. doi 10.1111/jgs.16468.
• Woods RL, Polekhina G, Wolfe R, Nelson MR, Ernst ME, Reid CM, Shah RC, Lockery JE, Orchard SG, Murray AM, McNeil JJ; on behalf of the ASPREE Investigator Group. No modulation of aspirin’s effect by body weight in healthy older men and women. Circulation. 2020 March 30 doi.org/10.1161/CIRCULATIONAHA.119.044142.
• Ryan J, Storey E, Murray AM, Woods RL, Wolfe R, Reid CM, Nelson MR, Chong T, Williamson JD, Ward SA, Lockery JE, Orchard SG, Trevaks R, Kirpach B, Newman AB, Ernst ME, McNeil JJ, Shah RC. Randomized Placebo-controlled Trial of the effects of Aspirin on Dementia and Cognitive Decline. Neurology.  2020 Mar 25  doi.org/10.1212/WNL.0000000000009277.
• Barker AL, Soh SE, Sanders KM, Pasco J, Khosla S, Ebeling PR, Ward SA, Peeters G, Talevski J, Cumming RG, Seeman E, McNeil JJ. Aspirin and fracture risk: a systematic review and exploratory meta-analysis of observational studies. BMJ Open. 2020 Feb 20;10(2):e026876 doi: 10.1136/bmjopen-2018-026876.
• Ryan J, Woods RL, Murray AM, Shah RC, Britt C, Reid CM, Wolfe R, Nelson MR, Lockery JE, Orchard SG, Trevaks R, Chong T, McNeil JJ, Storey E. Normative Performance of Older Individuals on the Hopkins Verbal Learning Test-Revised (HVLT-R) According to Ethno-Racial Group, Gender, Age and Education Level. The Clinical Neuropsychologist. 2020 Feb 26 doi:10.1080/13854046.2020.1730444.
• Agustini B, Mohebbi M, Woods RL, McNeil JJ, Nelson MR, Shah RC, Murray AM, Ernst ME, Reid CM, Tonkin A, Lockery JE, Berk M, on behalf of the ASPREE Investigator Group. The association of antihypertensive use and depressive symptoms in a large older population with hypertension living in Australia and the United States. Journal of Human Hypertension. 2020; Pubmed 32001828 doi.org/10.1038/s41371-020-0303-y.
• Pinese M, Lacaze P, Rath E, Stone A, Brion MJ, Ameur A, Nagpal S, Puttick C, Husson S, Degrave D, Navin Cristina T, Kahl VS, Statham A, Woods R, McNeil J, Riaz M, Barr M, Nelson M, Reid C, Murray A, Shah R, Wolfe R, Atkins J, Fitzsimmons C, Cairns H, Green M, Carr V, Cowley M, Pickett H, James P, Powell J, Kaplan W, Gibson G, Gyllensten U, Cairns M, McNamara M, Dinger M, Thomas D. The Medical Genome Reference Bank contains whole genome and phenotype data of 2,570 healthy elderly. Nature Communications Online. 2020 Jan 23. Paper #435 (2020) doi:10.1038/s41467-019-14079-0.
• Voskoboinik I, Lacaze P, Jang HS, Flinsenberg TWH, Fernando SL, Kerridge I, Riaz M, Sebra R, Thia KYT, Noori T, Schadt EE, McNeil JJ, Trapani JA. Prevalence and Disease Predisposition of p.A91V perforin in an aged Caucasian Population. Blood Journal. Epub ahead of print 2020 Jan 13 doi:10.1182/blood-2019003487.

2019

• Lockery JE, Rigby J, Collyer TA, Stewart A, Woods RL, McNeil JJ, Reid CM, Ernst ME, on behalf of the ASPREE Investigator Group. Optimising medication data collection in a large-scale clinical trial. Plos One  2019; 14 (12) doi.org/10.1371/journal.pone.0226868
• Chowdhury EK, Nelson MR, Ernst ME, Margolis KL, Beilin LJ, Johnston CI, Woods RL, Murray AM, Wolfe R, Storey E, Shah RC, Lockery JE, Tonkin AM, Newman AB, Williamson JD, Abhayaratna WP, Stocks NP, Fitzgerald SM, Orchard SG, Trevaks RE, Donnan GA, Grimm R, McNeil JJ, Reid CM, for the ASPREE investigator Group. Factors associated with treatment and control of hypertension in a healthy elderly population free of cardiovascular disease: a cross-sectional study. American Journal of Hypertension 2019 Dec 06. doi.org/10.1093/ajh/hpz192
• Jamadar SD, Sforazzini F, Raniga P, Ferris NJ, Paton B, Bailey MJ, Brodtmann A, Yates PA, Donnan GA, Ward SA, Woods RL, Storey E, McNeil JJ, Egan GF,  ASPREE Investigator Group. Sexual Dimorphism of Resting-State Network Connectivity in Healthy Ageing. The journals of gerontology. Series B, Psychological sciences and social sciences. 2019; 74 (7): 1121-1131. doi:10.1093/geronb/gby004
• Lockery JE, Collyer TA, Reid CM, Ernst ME, Gilbertson D, Hay N, Kirpach B, McNeil JJ, Nelson MR, Orchard SG, Pruksawongsin K, Shah RC, Wolfe R, Woods RL & on behalf of the ASPREE Investigator Group. Overcoming challenges to data quality in the ASPREE clinical trial. Trials 2019, 20: 686. doi:10.1186/s13063-019-3789-2
• Davis SR, Bell RJ, Robinson PJ, Handelsman DJ, Gilbert T, Phung J, Desai R, Lockery JE, Woods RL, Wolfe RS, Reid CM, Nelson  MR, Murray AM, McNeil JJ. Testosterone and estrone increase from the age of 70 years; findings from the Sex Hormones in Older Women Study. J Clinical Endocrinology & Metabolism, 2019 Aug 13; pii: jc.2019-00743. doi: 10.1210/jc.2019-00743. [Epub ahead of print]
• Agustini B, Mohebbi M, Woods RL, McNeil JJ, Nelson MR, Shah RC, Murray AM, Ernst ME, Reid CM, Tonkin A, Lockery JE, Berk M. ASPREE Investigator Group. Association Between Statin Use and Depressive Symptoms in a Large Community-Dwelling Older Population Living in Australia and the USA: A Cross-Sectional Study. CNS Drugs. 2019 May 6. doi: 10.1007/s40263-019-00633-3 [Epub ahead of print]
• Polkinghorne KR, Wolfe R, Jachno KM, Wetmore JB, Woods RL, McNeil JJ, Nelson MR, Reid CM, Murray AM; ASPREE Investigator Group. Prevalence of chronic kidney disease in the elderly using the ASPirin in Reducing Events in the Elderly study cohort. Nephrology 2019 24:1248-1256. doi: 10.1111/nep.13565
• Mohebbi M, Agustini B, Woods RL, McNeil JJ, Nelson MR, Shah RC, Nguyen V, Storey E, Murray AM, Reid CM, Kirpach B, Wolfe RS, Lockery JE, Berk M; ASPREE Investigator Group. Prevalence of depressive symptoms and its associated factors among healthy community-dwelling older adults living in Australia and the United States. Int J Geriatr Psychiatry. 2019 Apr 16. doi: 10.1002/gps.5119 [Epub ahead of print]
• Lockery JE, Collyer TA, Abhayaratna WP, Fitzgerald SM, McNeil JJ, Nelson MR, Orchard SG, Reid C, Stocks NP, Trevaks RE, Woods RL. Recruiting general practice patients for large clinical trials: lessons from the Aspirin in Reducing Events in the Elderly (ASPREE) study. Med J Aust 2019; 210 (4): 168-173. doi: 10.5694/mja2.12060
• CORRESPONDENCE McNeil JJ, Woods RL, Murray AM, for the ASPREE Investigator Group. Effects of aspirin in the healthy elderly. Correspondence. N Engl J Med 2019; 380 (18): 1776-7. doi:10.1056/NEJMc1901774
• COMMENTARY Chan AT, McNeil J. Aspirin and Cancer Prevention in the Elderly: Where Do We Go From Here? Gastroenterology. 2019 Feb;156(3):534-538. doi: 10.1053/j.gastro.2018.11.063
• McNeil JJ, Woods RL, Ward SA, Britt CJ, Lockery JE, Beilin LJ, Owen AJ. Cohort Profile: The ASPREE Longitudinal Study of Older Persons (ALSOP). International Journal of Epidemiology, 2019. doi:https://doi.org/10.1093/ije/dyy279

2018

• Lacaze P, Pinese M, Kaplan W, Stone A, Brion M, Woods RL, McNamara M, McNeil JJ, Dinger ME, Thomas DM. The Medical Genome Reference Bank: a whole-genome data resource of 4,000 healthy elderly individuals. Rationale and cohort design. European Journal of Human Genetics, 2018. doi: 10.1038/s41431-018-0279-z 
• Stocks N, González-Chica DA, Lockery JE, Shah RC, Murray AM, Wolfe R, Nelson MR, Reid CM, McNeil JJ, Woods RL, on behalf of the ASPREE Investigator Group. Quality of Life for 19,114 participants in the ASPREE (Aspirin in Reducing Events in the Elderly) Study and their association with sociodemographic and lifestyle modifiable risk factors. Quality of Life Research, 2018, pp.1-12. doi: 10.1007/s11136-018-2040-z
• McNeil JJ*, Woods RL*, Nelson MR, Reid CM, Kirpach B, Wolfe R, Storey E, Shah RC, Lockery JE, Tonkin AM, Newman AB, Williamson JD, Margolis KL, Ernst ME, Abhayaratna WP, Stocks N, Fitzgerald SM, Orchard SG, Trevaks RE, Beilin LJ, Donnan GA, Gibbs P, Johnston CI, Ryan J, Radziszewska B, Grimm R & Murray AM, on behalf of the ASPREE Investigator Group (* joint first authors). Effect of aspirin on disability-free survival in the healthy elderly. New England Journal of Medicine, 2018, 379:1499-1508. doi: 10.1056/nejmoa1800722
• McNeil JJ*, Nelson MR*, Woods RL, Lockery JE, Wolfe R, Reid CM, Kirpach B, Shah RC, Ives DG, Storey E, Ryan J, Tonkin AM, Newman AB, Williamson JD, Margolis KL, Ernst ME, Abhayaratna WP, Stocks N, Fitzgerald SM, Orchard SG, Trevaks RE, Beilin LJ, Donnan GA, Gibbs P, Johnston CI, Radziszewska B, Grimm R & Murray AM, on behalf of the ASPREE Investigator Group (* joint first authors). Effect of aspirin on all-cause mortality in the healthy elderly. New England Journal of Medicine, 2018, 379:1499-1508. doi: 10.1056/NEJMoa1803955
• McNeil JJ, Wolfe R, Woods RL, Tonkin AM, Donnan GA, Nelson MR, Reid CM, Lockery JE, Kirpach B, Storey E, Shah RC, Williamson JD, Margolis KL, Ernst ME, Abhayaratna WP, Stocks N, Fitzgerald SM, Orchard SG, Trevaks RE, Beilin LJ, Johnston CI, Ryan J, Radziszewska B, Jelinek M, Malik M, Eaton C, Brauer D, Cloud G, Wood E, Mahady SE, Satterfield S, Grimm R & Murray AM, on behalf of the ASPREE Investigator Group. Effect of aspirin on cardiovascular events and bleeding in the healthy elderly. New England Journal of Medicine, 2018, 379:1499-1508. doi: 10.1056/nejmoa1805819
• Ryan J, Woods RL, Britt C, Murray AM, Shah RC, Reid CM, Kirpach B, Wolfe RS, Nelson MR, Lockery JE, Orchard SG, Trevaks RE, McNeil JJ, Storey E; on behalf of the ASPREE Investigator Group. Normative performance of healthy older individuals on the Modified Mini-Mental State (3MS) examination according to ethno-racial group, gender, age, and education level. The Clinical Neuropsychologist, published online Jul 2018. doi.org/10.1080/13854046.2018.1488996
• Margolis KL, Mahady SE, Nelson MR, Ives DG, Satterfield S, Britt C, Ekram S, Lockery JE, Schwartz EC, Woods RL, McNeil JJ, Wood EM. Development of a standardized definition for clinically significant bleeding in the ASPirin in Reducing Events in the Elderly (ASPREE) trial. Contemporary Clinical Trials Communications, 2018, Vol 11, 30-36. doi.org/10.1016/j.conctc.2018.05.015
• Wolfe R, Murray AM, Woods, RL, Kirpach B, Gilbertson D, Shah RC, Nelson MR, Reid CM, Ernst ME, Lockery JE, Donnan GA, Williamson J, McNeil JJ. The aspirin in reducing events in the elderly trial: Statistical analysis plan. International Journal of Stroke, 2018, Vol.13(3), pp.335-338. doi.org/10.1177/1747493017741383
• Fransquet PD, Lacaze P, Woods RL, McNeil JJ, Saffery R, Ryan J. Blood DNA methylation as a potential biomarker of dementia: a systematic review. Alzheimer’s & Dementia, 2017, 14(1): 81-103. IF:11.0. DOI: 10.1016/j.jalz.2017.10.002.
• Ward SA, Storey E, Woods RL, Hamilton GS, Kawasaki R, Janke AL, Naughton MT, O’Donoghue F, Wolfe R, Wong TY, Reid CM, Abhayaratna WP, Stocks N, Trevaks R, Fitzgerald S, Hodgson LAB, Robman L,  Workman  B, Mcneil JJ. The Study of Neurocognitive Outcomes, Radiological and Retinal Effects of Aspirin in Sleep Apnoea- rationale and methodology of the SNORE-ASA study. Contemporary clinical trials, 2018, Vol.64, pp.101-111. doi.org/10.1016/j.cct.2017.10.016
• Mohebbi M, Nguyen V, McNeil JJ, Woods RL, Nelson MR, Shah RC, Storey E, Murray AM, Reid CM, Kirpach B, Wolfe, R, Lockery JE, Berk M, ; on behalf of the ASPREE investigator group. Psychometric properties of a short form of the Center for Epidemiologic Studies Depression (CES-D-10) scale for screening depressive symptoms in healthy community dwelling older adults. General Hospital Psychiatry, 2018; 51:118-125. doi: 10.1016/j.genhosppsych.2017.08.002.

2017

• McNeil JJ, Woods RL, Nelson MR, Murray AM, Reid CM, Kirpach B, Storey E, Shah RC, Wolfe R, Tonkin AM, Newman AB, Williamson JD, Lockery JE, Margolis KL, Ernst ME, Abhayaratna WP, Stocks N, Fitzgerald SM, Trevaks RE, Orchard SG, Beilin LJ, Donnan GA, Gibbs P, Johnston CI, Grimm RH; on behalf of the ASPREE investigator group. Baseline Characteristics of Participants in the ASPREE (ASPirin in Reducing Events in the Elderly) Study. J Gerontol A Biol Sci Med Sci, 2017 Oct 12, Vol. 00, No. 00, 1–8. doi:10.1093/gerona/glw342
• Ward SA, Raniga P, Ferris NJ, Woods RL, Storey E, Bailey MJ, Brodtmann A, Yates PA, Donnan GA, Trevaks RE, Wolfe R, Egan GF, McNeil JJ; (Joint Senior authorship); on behalf of the ASPREE investigator group. ASPREE-NEURO study protocol: A randomized controlled trial to determine the effect of low-dose aspirin on cerebral microbleeds, white matter hyperintensities, cognition, and stroke in the healthy elderly. Int J Stroke. 2017;12(1):108-113. doi:10.1177/1747493016669848
• Lacaze P, Winship I, McNeil JJ. Penetrance and the Healthy Elderly. Genetic testing and molecular biomarkers, 2017, Vol.21(11), pp.637-640 doi.org/10.1089/gtmb.2017.0126
• Robman L, Guymer R, Woods RL, Ward SA, Wolfe R, Phung J, Hodgson L, Makeyeva G, Aung KZ, Gilbert T, Lockery JE, Le-Pham Y, Orchard S, Storey E, Abhayaratna W, Reid D, Ernst ME, Nelson MR, Reid C,  McNeil, JJ. Age-related macular degeneration in a randomized controlled trial of low-dose aspirin: Rationale and study design of the ASPREE-AMD study. Contemporary Clinical Trials Communications, 2017, Vol.6, pp.105-114. doi:10.1016/j.conctc.2017.03.005
• Lacaze P, Ryan J, Woods RL, Winship I, McNeil JJ. Pathogenic variants in the healthy elderly: unique ethical and practical challenges. Journal of Medical Ethics, 2017, Vol. 43(10), p.714 DOI: 10.1136/medethics-2016-103967
• Lacaze P, Woods RL, Zoungas S, McNeil JJ. The genomic potential of the Aspirin in Reducing Events in the Elderly and Statins in Reducing Events in the Elderly studies. Internal medicine Journal, 2017, Vol.47(4), pp.461-463 doi.org/10.1111/imj.13384
• Eisen DP, Moore EM, Leder K,  Lockery JE, McBryde ES, McNeil JJ, Pilcher D, Wolfe R, Woods RL. AspiriN To Inhibit SEPSIS (ANTISEPSIS) randomised controlled trial protocol. BMJ Open. 2017;7:e013636. doi: 10.1136/bmjopen-2016-013636
• Lacaze P, Winship I, McNeil J. Penetrance and the Healthy Elderly. Genet Test Mol Biomarkers. 2017 Nov;21(11):637-640. doi: 10.1089/gtmb.2017.0126 Epub 2017 Sep 6.

2016

• Berk M, Woods RL, Nelson MR, Shah RC, Reid CM, Storey E, Fitzgerald SM, Lockery JE, Wolfe R, Mohebbi M, Murray AM, Kirpach B, Grimm R, McNeil JJ. ASPREE-D: Aspirin for the prevention of depression in the elderly. International Psychogeriatrics, 2016, doi:10.1017/S104161021600079X

2015

• Lowthian JA, Britt CJ, Rance G, Lin FR, Woods RL, Wolfe R, Nelson MR, Dillon HA, Ward S, Reid CM, Lockery JE, Nguyen TT, McNeil JJ, Storey E. Slowing the progression of age-related hearing loss: Rationale and study design of the ASPIRIN in HEARING, retinal vessels imaging and neurocognition in older generations (ASPREE-HEARING) trial. Contemp Clin Trials. 2015; 46; 60-66 doi: 10.1016/j.cct.2015.11.014
• Barker AL, McNeil JJ, Seeman E, Ward SA, Sanders KM, Khosla S, Cumming RG, Pasco JA, Bohensky MA, Ebeling PR, Woods RL, Lockery JE, Wolfe R, Talevski J, and the ASPREE Investigator Group. A randomised controlled trial of low-dose aspirin for the prevention of fractures in healthy older people: protocol for the ASPREE-Fracture substudy. Inj Prev. 2015, pii: injuryprev-2015-041655. doi: 10.1136/injuryprev-2015-041655. [Epub ahead of print] PMID: 26002770

2014

• Chong EW, Guymer RH, Robman LD. Does aspirin increase the risk of age-related macular degeneration? Expert Opinion on Drug Safety, 2014,13:691-3 doi: 10.1517/14740338.2014.914169

2013

• ASPREE Investigator Group. Study design of ASPirin in Reducing Events in the Elderly (ASPREE): a randomized, controlled trial. Contemporary Clinical Trials, 2013, 36: 555–564 doi: org/10.1016%2Fj.cct.2013.09.014
• COMMENTARY Nelson MR. General practice-based clinical trials. Perspectives, Med J Aust 2013; 198 (3): doi: 10.5694/mja12.11061

2012

• Reid CM, Storey E, Wong TY, Woods RL, Tonkin A, Wang JJ, Kam A, Janke A, Essex R, Abhayaratna WP, Budge MM; on behalf of the ASPREE Study Group. Aspirin for the prevention of cognitive decline in the elderly: rationale and design of a neuro-vascular imaging study (ENVIS-ion). BMC Neurol, 2012, 12:3. doi: 10.1186/1471-2377-12-3.
• Linden MD, Tran HA, Woods RL, Tonkin AM. High platelet reactivity and antiplatelet therapy resistance. Seminars in Thrombosis and Hemostasis, 2012, 38(2):200-12. DOI: 10.1055/s-0032-1301417

2009

• Woods RL, Tonkin AM, Nelson MR, Britt HC, Reid CM. Should aspirin be used for the primary prevention of cardiovascular disease in people with diabetes? Med J Aust, 2009, 190:614-5 PMID:19485837

2008

• Nelson MR, Reid CM, Ames DA, Beilin LJ, Donnan GA, Gibbs P, Johnston CI, Krum H, Storey E, Tonkin A, Wolfe R, Woods R, McNeil JJ. Feasibility of conducting a primary prevention trial of low-dose aspirin for major adverse cardiovascular events in older people in Australia: results from the ASPirin in Reducing Events in the Elderly (ASPREE) pilot study. Med J Aust, 2008, 189:105-109 PMID:18637782

2005

• Nelson MR, Liew D, Bertram M, Vos T. Epidemiological modelling of routine use of low-dose aspirin in Australia for the primary prevention of coronary heart disease and stroke in those aged 70 years and above. BMJ 2005; 330:1306-1308.

2003

• Nelson MR, Reid CM, Johnstone CI, Krum H, Storey E, Tonkin A, Beilin LJ, Donnan GA, McNeil JJ.  After ANBP2 – ASPREE  Clinical And Experimental Pharmacology And Physiology, 2003, Vol.30(7), pp.A59-A59.
• ASPREE Study Group. Nelson MR, Reid CM, Beilin LJ, Donnan GA, Johnston CI, Krum H, Storey E, Tonkin AM, McNeil JJ.  Rationale for a primary prevention trial in the elderly of low dose aspirin for the prevention of major adverse cardiovascular events and vascular dementia in Australian general practice.  ASPirin in Reducing Events in the Elderly (ASPREE). J Drugs and Aging. 2003; 20(12):897-903.