{"id":193,"date":"2021-07-05T15:51:42","date_gmt":"2021-07-05T15:51:42","guid":{"rendered":"https:\/\/aspree.org\/usa\/?page_id=193"},"modified":"2021-09-01T04:43:16","modified_gmt":"2021-09-01T04:43:16","slug":"governance","status":"publish","type":"page","link":"https:\/\/aspree.org\/usa\/about-us\/governance\/","title":{"rendered":"ASPREE governance"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.5.1″ background_color=”#26619A” custom_padding=”0px||0px||false|false” background_color_gradient_direction_tablet=”360deg” background_color_gradient_start_position_tablet=”49%” background_color_gradient_end_position_tablet=”79%” background_size_tablet=”cover” background_position_tablet=”center_right” background_position_phone=”center_right” locked=”off”][et_pb_row column_structure=”2_5,3_5″ use_custom_gutter=”on” gutter_width=”1″ make_equal=”on” custom_padding_last_edited=”on|tablet” _builder_version=”4.5.1″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” width=”100%” max_width=”100%” custom_padding=”0px||0px|4%|false|false” custom_padding_tablet=”0px|||0%|false|false” custom_padding_phone=”” locked=”off”][et_pb_column type=”2_5″ _builder_version=”4.5.1″ custom_padding=”30px||||false|false” custom_padding__hover=”|||”][et_pb_ds_breadcrumbs module_class=”light” _builder_version=”4.5.1″ _module_preset=”default” locked=”on”][\/et_pb_ds_breadcrumbs][et_pb_text _builder_version=”4.5.1″ header_font=”|700|||||||” header_font_size=”42px” header_line_height=”1.15em” background_layout=”dark” width=”80%” max_width=”520px” module_alignment=”center” custom_margin=”3em||20px||false|false” custom_margin_tablet=”3em||||false|false” custom_margin_phone=”” custom_margin_last_edited=”on|desktop” header_font_size_tablet=”34px” header_font_size_phone=”24px” header_font_size_last_edited=”on|desktop” module_alignment_tablet=”” module_alignment_phone=”” module_alignment_last_edited=”on|tablet”]<\/p>\n

GOVERNANCE\u00a0\u00a0<\/h1>\n

[\/et_pb_text][et_pb_text _builder_version=”4.5.1″ text_font_size=”24px” background_layout=”dark” width=”80%” max_width=”520px” module_alignment=”center” custom_margin=”||40px||false|false” custom_padding=”||||false|false” text_font_size_tablet=”20px” text_font_size_phone=”16px” text_font_size_last_edited=”on|desktop”]Multi-level, bi-national committees drive ASPREE’s high standards of research practice, data capture, study findings and publications.[\/et_pb_text][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.5.1″ background_image=”https:\/\/aspree.org\/wp-content\/uploads\/sites\/3\/2021\/07\/Governance-Image.png” background_position=”top_center” custom_padding=”|||” background_last_edited=”off|desktop” custom_padding__hover=”|||”][et_pb_code _builder_version=”4.5.1″ _module_preset=”default” height=”34em” height_tablet=”250px” height_phone=”250px” height_last_edited=”on|phone”][\/et_pb_code][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ specialty=”on” padding_top_bottom_link_2=”false” padding_left_right_link_2=”true” padding_right_2=”0px” padding_left_2=”0px” module_class=”texture-left” _builder_version=”4.5.1″ _module_preset=”default” inner_max_width=”80%” custom_margin=”||||false|false” custom_padding=”||90px||false|false” border_color_bottom=”#bdbec0″][et_pb_column type=”1_3″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.5.1″ text_font=”|600|||||||” text_text_color=”#26619a” text_font_size=”32px” header_2_font=”|||on|||||” header_2_font_size=”32px” text_font_size_tablet=”28px” text_font_size_phone=”24px” text_font_size_last_edited=”on|phone” header_2_font_size_tablet=”28px” header_2_font_size_phone=”24px” header_2_font_size_last_edited=”on|phone” locked=”off”]<\/p>\n

Governance<\/h2>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”2_3″ specialty_columns=”2″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_row_inner admin_label=”PUT CONTENT BELOW AS A TEXT AND IMAGES” _builder_version=”4.5.1″ _module_preset=”default” max_width=”840px” custom_padding=”|0px||0px|true|true”][et_pb_column_inner saved_specialty_column_type=”2_3″ _builder_version=”4.5.1″ _module_preset=”default”][et_pb_text _builder_version=”4.5.1″ _module_preset=”default”]<\/p>\n

The ASPREE International Steering Committee (ISC) is comprised of senior researchers in the United States and Australia and is responsible for the overall management and progress of the project.<\/p>\n

ASPREE management is structured so that specialist committees look after different aspects of the project, such as the International Data Management Committee (IDMC), and provide the ISC with accurate, timely information.<\/p>\n

[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][\/et_pb_section][et_pb_section fb_built=”1″ specialty=”on” admin_label=”TABBED CONTENT (LIGHT)” module_id=”scroll_tab1″ module_class=”tabs” _builder_version=”4.5.1″ _module_preset=”default” inner_max_width=”80%” custom_margin=”||||false|false” custom_padding=”||90px||false|false” border_width_bottom=”1px” border_color_bottom=”#bdbec0″][et_pb_column type=”1_3″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text admin_label=”TITLE” _builder_version=”4.5.1″ header_2_font=”|600|||||||” header_2_font_size=”32px” header_2_font_size_tablet=”28px” header_2_font_size_phone=”24px” header_2_font_size_last_edited=”on|desktop” locked=”off”]<\/p>\n

ASPREE Project Committees<\/h3>\n

[\/et_pb_text][et_pb_text admin_label=”1 ISC” module_class=”tab-link” _builder_version=”4.5.1″ _module_preset=”default” text_text_color=”#000000″ link_text_color=”#2F2F2F” background_layout=”dark” custom_margin=”||20px||false|false” motion_trigger_start=”top”]<\/p>\n

The Principal Investigator Committee<\/span><\/h4>\n

[\/et_pb_text][et_pb_text admin_label=”1 ISC” module_class=”tab-link” _builder_version=”4.5.1″ _module_preset=”default” text_text_color=”#000000″ link_text_color=”#2F2F2F” background_layout=”dark” custom_margin=”||20px||false|false” motion_trigger_start=”top”]<\/p>\n

The International Steering Committee<\/span><\/h4>\n

[\/et_pb_text][et_pb_text admin_label=”2 IEC” module_class=”tab-link” _builder_version=”4.5.1″ _module_preset=”default” text_text_color=”#000000″ link_text_color=”#2F2F2F” background_layout=”dark” custom_margin=”||20px||false|false” motion_trigger_start=”top”]<\/p>\n

The International Executive Committee<\/span><\/h4>\n

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Observational Study Monitoring Board\u00a0<\/span><\/h4>\n

[\/et_pb_text][et_pb_text admin_label=”4 IDMC” module_class=”tab-link” _builder_version=”4.5.1″ _module_preset=”default” text_text_color=”#000000″ link_text_color=”#2F2F2F” background_layout=”dark” custom_margin=”||20px||false|false” motion_trigger_start=”top”]<\/p>\n

The International Data Management Committee<\/span><\/h4>\n

[\/et_pb_text][et_pb_text admin_label=”5 DMC” module_class=”tab-link” _builder_version=”4.5.1″ _module_preset=”default” text_text_color=”#000000″ link_text_color=”#2F2F2F” background_layout=”dark” custom_margin=”||20px||false|false” motion_trigger_start=”top”]<\/p>\n

Data Management Committee<\/span><\/h4>\n

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Bio-specimen Access Committee<\/span><\/h4>\n

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End Point Adjudications Committee<\/span><\/h4>\n

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USA Operations Committee<\/span><\/h4>\n

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Australian Committees<\/span><\/h4>\n

[\/et_pb_text][et_pb_text admin_label=”12 Other Committes” module_class=”tab-link” _builder_version=”4.5.1″ _module_preset=”default” text_text_color=”#000000″ link_text_color=”#2F2F2F” background_layout=”dark” custom_margin=”||20px||false|false” custom_padding=”7px|||||” motion_trigger_start=”top”]<\/p>\n

Working Groups<\/span><\/h4>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”2_3″ specialty_columns=”2″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_row_inner admin_label=”Committees” module_class=”tab-content” _builder_version=”4.5.1″ _module_preset=”default” max_width=”840px”][et_pb_column_inner saved_specialty_column_type=”2_3″ _builder_version=”4.5.1″ _module_preset=”default”][et_pb_text _builder_version=”4.5.1″ text_text_color=”#0c4072″ header_2_font=”|600|||||||” header_2_font_size=”32px” header_2_font_size_tablet=”28px” header_2_font_size_phone=”24px” header_2_font_size_last_edited=”on|desktop” locked=”off”]<\/p>\n

The Principal Investigator (PI) Committee<\/h2>\n

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The PI Committee is responsible for the governance of the study in accordance with the requirements of the funding bodies and their institutions. It also oversees policies related to data availability and access.<\/p>\n

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The International Steering Committee<\/span><\/h2>\n

[\/et_pb_text][et_pb_text admin_label=”ISC text ” _builder_version=”4.5.1″ _module_preset=”default” text_text_color=”#000000″ link_text_color=”#c9a700″ header_text_color=”#000000″ background_layout=”dark”]<\/p>\n

The International Steering Committee (ISC) is responsible for the overall management and conduct of the ASPREE Project in Australia and the USA. This committee, which meets quarterly, oversees protocol implementation and adherence, financial management and study progress. Various sub-committees and sub-studies report to the ISC.<\/p>\n

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The International Executive Committee<\/span><\/h2>\n

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The International Executive Committee (IEC) is a smaller committee derived from the ISC, that meets twice a month. This committee oversees operational management, study and sub-study progress (including generation of reports), data access and publications. Various sub-committees and sub-studies report to the IEC.<\/p>\n

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Monitoring and Safety Board<\/span><\/h2>\n

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The NIA (the major funding body for the project) appointed an independent Data Safety and Monitoring Board (DSMB) with the responsibility of monitoring quality control of the data, trial progress and safety aspects every six months during the ASPREE clinical trial.<\/p>\n

The independent Observational Study Monitoring Board (OSMB) appointed by the NIA and NCI, monitors retention and data quality and any new ancillary studies during the ASPREE-XT study.<\/p>\n

Both boards report to the NIA<\/a>.<\/p>\n

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The International\u00a0<\/span>Data Management Committee<\/h2>\n

[\/et_pb_text][et_pb_text admin_label=”IDMC text” _builder_version=”4.5.1″ _module_preset=”default” text_text_color=”#000000″ link_text_color=”#c9a700″ header_text_color=”#000000″ background_layout=”dark”]<\/p>\n

The International Data Management Committee (IDMC) monitors the ASPREE data management processes in Australia and the USA. The IDMC reviews data reports generated by the Data Management Committee (DMC) for completeness and quality. The IDMC Chair reports to the IEC on data management issues (apart from data access) associated with the study.<\/p>\n

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The\u00a0<\/span>Data Management Committee<\/h2>\n

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The Data Management Committee (DMC) is responsible for the project’s web-based data system: overseeing programming and changes to the database and day-to-day management of the database and systems of data collection. The DMC prepares reports and interrogates the database to respond to queries from study investigators and managers, in addition to resolving issues relating to data capture and the database functionality.\u00a0 It reviews reports generated by the database and the data from the quality assurance program. The DMC reports to the IDMC.<\/p>\n

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Bio-specimen Access Committee<\/h2>\n

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The Bio-specimen Access Committee is responsible for review and approval of the use of ASPREE’s stored bio-specimens for genomics, biomarkers and any other analyses.<\/p>\n

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The Endpoint Adjudication\u00a0<\/span>Committee<\/h2>\n

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The Endpoint Adjudication Committee (EAC) evaluates ASPREE participant outcomes while still blinded to assigned treatment in the ASPREE trial (100mg aspirin or matched placebo).\u00a0 Specialist sub-committees examine relevant clinical records to adjudicate specific endpoint outcomes of: dementia, cancer, cardiac events, stroke, cause of death, disability, depression and clinically significant bleeding.\u00a0 Each sub-committee has members from Australia and the USA with expertise relevant to the clinical or health event to be adjudicated.<\/p>\n

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United States Operations Committee<\/h2>\n

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The United States Operations Committee is responsible for implementing the study, monitoring progress, ensuring adherence and standardization throughout the many study sites in the United States. This committee ensures quality control review of laboratory data, clinical measurements and data collection, completeness of data and transfer of data to the Data Management Center, site monitoring and appropriate source documentation.<\/p>\n

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Australian Committees<\/h2>\n

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The Australian Management Committee<\/strong> is responsible for implementing the project in Australia, monitoring study progress and ensuring adherence and standardization throughout the study across the sites.<\/p>\n

The Australian Operations Committee<\/strong> monitors and manages the day to day operations of Australian staff, ensuring compliance with the study protocol and objectives. Responsibilities include keeping study staff up to date on study procedures and activities, monitoring study conduct and providing instruction and refresher training. Operations meetings are held monthly and report to the Australian Management Committee.<\/p>\n

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Working Groups<\/h2>\n

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The Presentations, Publications and Ancillary Studies Committee (PPA) reviewed all publications and presentations borne from the ASPREE clinical trial and sub-studies.<\/p>\n

Since 2020, Special Interest Working Groups oversee publications (data analysis and manuscript preparation), grant applications and future studies into aspects of health or disease in the ASPREE Project. Each group reports progress of publications to the IEC.<\/p>\n

Current Special Interest Working Groups include:<\/p>\n

    \n
  • Microbiome & ALSOP (Australian Longitudinal Study of Older Persons) sub-studies<\/li>\n
  • Cancer \/ sub-types<\/li>\n
  • Cancer genomics<\/li>\n
  • Cardiovascular disease\/hypertension<\/li>\n
  • Dementia<\/li>\n
  • Depression<\/li>\n
  • Disability and frailty<\/li>\n
  • Genomics<\/li>\n
  • Medication use (Conmeds)<\/li>\n<\/ul>\n

     <\/p>\n

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    GOVERNANCE\u00a0\u00a0Multi-level, bi-national committees drive ASPREE’s high standards of research practice, data capture, study findings and publications.GovernanceThe ASPREE International Steering Committee (ISC) is comprised of senior researchers in the United States and Australia and is responsible for the overall management and progress of the project. ASPREE management is structured so that specialist committees look after different […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":183,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"_links":{"self":[{"href":"https:\/\/aspree.org\/usa\/wp-json\/wp\/v2\/pages\/193"}],"collection":[{"href":"https:\/\/aspree.org\/usa\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/aspree.org\/usa\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/aspree.org\/usa\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/aspree.org\/usa\/wp-json\/wp\/v2\/comments?post=193"}],"version-history":[{"count":15,"href":"https:\/\/aspree.org\/usa\/wp-json\/wp\/v2\/pages\/193\/revisions"}],"predecessor-version":[{"id":2108,"href":"https:\/\/aspree.org\/usa\/wp-json\/wp\/v2\/pages\/193\/revisions\/2108"}],"up":[{"embeddable":true,"href":"https:\/\/aspree.org\/usa\/wp-json\/wp\/v2\/pages\/183"}],"wp:attachment":[{"href":"https:\/\/aspree.org\/usa\/wp-json\/wp\/v2\/media?parent=193"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}