{"id":153,"date":"2021-07-05T15:45:35","date_gmt":"2021-07-05T15:45:35","guid":{"rendered":"https:\/\/aspree.org\/usa\/?page_id=153"},"modified":"2024-02-04T22:10:10","modified_gmt":"2024-02-04T22:10:10","slug":"sub-studies","status":"publish","type":"page","link":"https:\/\/aspree.org\/usa\/sub-studies\/","title":{"rendered":"ASPREE sub-studies"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; custom_padding_last_edited=&#8221;off|desktop&#8221; _builder_version=&#8221;4.16&#8243; background_color=&#8221;#26619A&#8221; custom_padding=&#8221;0px||0px||false|false&#8221; custom_padding_tablet=&#8221;24vh||2vh||false|false&#8221; background_color_gradient_direction_tablet=&#8221;360deg&#8221; background_color_gradient_stops_tablet=&#8221;#2b87da 49%|#29c4a9 79%&#8221; background_color_gradient_start_position_tablet=&#8221;49%&#8221; background_color_gradient_end_position_tablet=&#8221;79%&#8221; background_size_tablet=&#8221;cover&#8221; background_position_tablet=&#8221;center_right&#8221; background_position_phone=&#8221;center_right&#8221; locked=&#8221;off&#8221; collapsed=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;2_5,3_5&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;1&#8243; make_equal=&#8221;on&#8221; custom_padding_last_edited=&#8221;on|tablet&#8221; _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; width=&#8221;100%&#8221; max_width=&#8221;100%&#8221; custom_padding=&#8221;0px||0px|4%|false|false&#8221; custom_padding_tablet=&#8221;0px|||0%|false|false&#8221; custom_padding_phone=&#8221;&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;30px||||false|false&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_ds_breadcrumbs module_class=&#8221;light&#8221; _builder_version=&#8221;4.5.1&#8243; _module_preset=&#8221;default&#8221; locked=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_ds_breadcrumbs][et_pb_text _builder_version=&#8221;4.16&#8243; header_font=&#8221;|700|||||||&#8221; header_font_size=&#8221;42px&#8221; header_line_height=&#8221;1.15em&#8221; background_layout=&#8221;dark&#8221; width=&#8221;80%&#8221; max_width=&#8221;520px&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;3em||20px||false|false&#8221; custom_margin_tablet=&#8221;3em||||false|false&#8221; custom_margin_phone=&#8221;&#8221; custom_margin_last_edited=&#8221;on|desktop&#8221; header_font_size_tablet=&#8221;34px&#8221; header_font_size_phone=&#8221;24px&#8221; header_font_size_last_edited=&#8221;on|desktop&#8221; module_alignment_tablet=&#8221;&#8221; module_alignment_phone=&#8221;&#8221; module_alignment_last_edited=&#8221;on|tablet&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h1>SUB-STUDIES<\/h1>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.16&#8243; text_font_size=&#8221;24px&#8221; background_layout=&#8221;dark&#8221; width=&#8221;80%&#8221; max_width=&#8221;520px&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;||40px||false|false&#8221; custom_padding=&#8221;||||false|false&#8221; text_font_size_tablet=&#8221;20px&#8221; text_font_size_phone=&#8221;16px&#8221; text_font_size_last_edited=&#8221;on|desktop&#8221; global_colors_info=&#8221;{}&#8221;]Adding value to clinical research;<br \/>\nthe ASPREE project is in a unique position to lead multiple sub-studies, each investigating specific health issues affecting older adults.<br \/>\n[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;3_5&#8243; _builder_version=&#8221;4.16&#8243; background_image=&#8221;https:\/\/aspree.org\/wp-content\/uploads\/sites\/3\/2021\/07\/055_Mobile_Labs_Study_Participants_352288.jpg&#8221; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_code _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; height=&#8221;34em&#8221; height_tablet=&#8221;250px&#8221; height_phone=&#8221;250px&#8221; height_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_code][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; specialty=&#8221;on&#8221; padding_right_2=&#8221;0px&#8221; padding_left_2=&#8221;0px&#8221; padding_top_bottom_link_2=&#8221;false&#8221; padding_left_right_link_2=&#8221;true&#8221; module_class=&#8221;texture-left&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; inner_max_width=&#8221;80%&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;||90px||false|false&#8221; border_color_bottom=&#8221;#bdbec0&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; text_font=&#8221;|600|||||||&#8221; text_text_color=&#8221;#26619a&#8221; text_font_size=&#8221;32px&#8221; header_line_height=&#8221;2em&#8221; header_2_font=&#8221;|600|||||||&#8221; header_2_font_size=&#8221;32px&#8221; header_2_line_height=&#8221;2em&#8221; header_3_font=&#8221;||||||||&#8221; text_font_size_tablet=&#8221;28px&#8221; text_font_size_phone=&#8221;24px&#8221; text_font_size_last_edited=&#8221;on|phone&#8221; header_2_font_size_tablet=&#8221;28px&#8221; header_2_font_size_phone=&#8221;24px&#8221; header_2_font_size_last_edited=&#8221;on|phone&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>What is a sub-study?<\/h2>\n<h3>\u2192 <a title=\"View ASPREE sub-studies\" href=\"#substudies\">View ASPREE sub-studies\u00a0<\/a><\/h3>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;2_3&#8243; specialty_columns=&#8221;2&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_row_inner admin_label=&#8221;PUT CONTENT BELOW AS A TEXT AND IMAGES&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;840px&#8221; custom_padding=&#8221;|0px||0px|true|true&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column_inner saved_specialty_column_type=&#8221;2_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>A sub-study (also known as an ancillary study) is a type of \u2018add-on\u2019 study that answers a separate research question within a larger research project. Sub-studies research specific health questions that are not included in the main study. The ASPREE project is in a unique position to conduct multiple sub-studies. The extra health information will help show the interrelationships between various factors that can affect how we age.<\/p>\n<p>Sub-studies provide new opportunities and experiences for participants &#8211; from donating blood samples, to having hearing tests, retinal photographs, sleep apnoea checks, MRI scans, to completing additional questionnaires about lifestyle, diet and more.<\/p>\n<p>Not all ASPREE participants were able to enrol in all sub-studies because each sub-study was introduced at a different stage in the trial, when funding became available or special equipment was present at the time. \u00a0However, most participants volunteered for at least one sub-study during the ASPREE trial.\u00a0<br \/> Some sub-studies use existing medical health records and\u00a0do not require any additional participant activities.<\/p>\n<p>Thanks to the generosity of our study participants, these sub-studies provide invaluable information about aspirin, health and aging, that we would not otherwise be able to collect in the main research project.<\/p>\n<p>[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; specialty=&#8221;on&#8221; disabled_on=&#8221;off|off|off&#8221; admin_label=&#8221;TABBED CONTENT (LIGHT)&#8221; module_id=&#8221;scroll_tab1&#8243; module_class=&#8221;tabs&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; inner_max_width=&#8221;80%&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;||90px||false|false&#8221; border_width_bottom=&#8221;1px&#8221; border_color_bottom=&#8221;#bdbec0&#8243; collapsed=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text admin_label=&#8221;TITLE&#8221; _builder_version=&#8221;4.16&#8243; header_2_font=&#8221;|600|||||||&#8221; header_2_font_size=&#8221;32px&#8221; header_2_font_size_tablet=&#8221;28px&#8221; header_2_font_size_phone=&#8221;24px&#8221; header_2_font_size_last_edited=&#8221;on|desktop&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2 id=\"substudies\">ASPREE sub-studies<\/h2>\n<p>Click on the sub-study below for more information<br \/>\n[\/et_pb_text][et_pb_text admin_label=&#8221;ACES&#8221; module_class=&#8221;tab-link&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; link_text_color=&#8221;#2F2F2F&#8221; custom_margin=&#8221;||20px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<a href=\"#\">ASPREE Cancer Endpoints Study (ACES)<\/a><br \/>\n[\/et_pb_text][et_pb_text admin_label=&#8221;ASPREE Cancer Treatment Study (ACTS)&#8221; module_class=&#8221;tab-link&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; link_text_color=&#8221;#2F2F2F&#8221; custom_margin=&#8221;||20px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><a href=\"#\">ASPREE Cancer Treatment Study (ACTS)<\/a><\/p>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;ASPREE-D&#8221; module_class=&#8221;tab-link&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; link_text_color=&#8221;#2F2F2F&#8221; custom_margin=&#8221;||20px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<a href=\"#\">ASPREE-D (Depression)<\/a><br \/>\n[\/et_pb_text][et_pb_text admin_label=&#8221;ASPREE-EWAS&#8221; module_class=&#8221;tab-link&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; link_text_color=&#8221;#2F2F2F&#8221; custom_margin=&#8221;||20px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<a href=\"#\">ASPREE-EWAS (Epigenetics)<\/a><br \/>\n[\/et_pb_text][et_pb_text admin_label=&#8221;GENOMICS&#8221; module_class=&#8221;tab-link&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; link_text_color=&#8221;#2F2F2F&#8221; custom_margin=&#8221;||20px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<a href=\"#\">ASPREE-G (Genomics)<\/a><br \/>\n[\/et_pb_text][et_pb_text admin_label=&#8221;ALSOP&#8221; module_class=&#8221;tab-link&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; link_text_color=&#8221;#2F2F2F&#8221; custom_margin=&#8221;||20px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<a href=\"#\">ASPREE Longitudinal Study of Older Persons (ALSOP)<\/a><br \/>\n[\/et_pb_text][et_pb_text admin_label=&#8221;MICROBIOME&#8221; module_class=&#8221;tab-link&#8221; _builder_version=&#8221;4.20.4&#8243; _module_preset=&#8221;default&#8221; link_text_color=&#8221;#2F2F2F&#8221; custom_margin=&#8221;||20px||false|false&#8221; global_colors_info=&#8221;{}&#8221;]<a href=\"#\">ASPREE-XT Microbiome<\/a>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;2_3&#8243; specialty_columns=&#8221;2&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_row_inner admin_label=&#8221;ACES&#8221; module_id=&#8221;scroll_tab2&#8243; module_class=&#8221;tab-content&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;840px&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column_inner saved_specialty_column_type=&#8221;2_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; header_2_font=&#8221;|600|||||||&#8221; header_2_font_size=&#8221;32px&#8221; header_2_font_size_tablet=&#8221;28px&#8221; header_2_font_size_phone=&#8221;24px&#8221; header_2_font_size_last_edited=&#8221;on|desktop&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2 style=\"text-align: left\">ASPREE Cancer Endpoints Study (ACES)<\/h2>\n<h3>A study of cancer in older adults<\/h3>\n<p>[\/et_pb_text][et_pb_image src=&#8221;https:\/\/aspree.org\/wp-content\/uploads\/sites\/3\/2021\/07\/shutterstock_176899670-2-e1426572389378.jpg&#8221; title_text=&#8221;Blood and tumour samples will be analysed to determine the effect of aspirin on cancer in the ASPREE Cancer Endpoints Sub-study&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_text admin_label=&#8221;caption&#8221; _builder_version=&#8221;4.19.3&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;0px|||||&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><em>Above: An illustration of a cancer tissue sample in preparation for close examination by researchers<\/em><\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.19.3&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#000000&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><strong>Summary<\/strong>: The ACES sub-study is funded by the National Cancer Institute (NCI), with the aim to understand factors associated with the development and spread of different types of cancers in older adults.<\/p>\n<p><span style=\"font-size: 16px\">Cancer is one of the most common diseases and a leading cause of death worldwide. Aging is a factor that increases the risk of cancer.<\/span><\/p>\n<p>ACES collects cancer related health information from participants annually and stores blood or saliva and cancer tissue samples (biospecimens) in a biorepository.<\/p>\n<p><strong>Aims:<\/strong> Research using these data may help predict what factors influence the incidence of specific cancers, their spread (metastasis) and the impact of a therapy (including low-dose aspirin) on cancer-free survival.<\/p>\n<p><strong>Health Information collected:<\/strong><\/p>\n<ul>\n<li>Participant reported lifestyle factors such as smoking and drinking history, body weight, cancer screening, tests, cancer diagnoses (old and new) and family history of cancer are collected annually<\/li>\n<li>Medical\/specialist health records related to a cancer diagnosis<\/li>\n<li>A sample of blood or saliva is stored in the ASPREE Biobank<\/li>\n<li>A tumor tissue sample \u2013 If a participant has a cancer biopsied or surgically removed as part of their Primary Care Provider&#8217;s (PCP&#8217;s) care, we collect a small sample of the tumor tissue from the pathology provider, for storage in the ASPREE Biobank<\/li>\n<\/ul>\n<p><strong>Location:<\/strong>\u00a0USA and Australia<\/p>\n<p><strong>Status:<\/strong>\u00a0Active, not recruiting. Started in 2013, data collection continues<\/p>\n<p><strong>Additional Information:\u00a0 <\/strong><a href=\"\/wp-content\/uploads\/sites\/3\/2021\/09\/Participant-QAs-for-ACES-sub-study.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Participant\u00a0FAQs<\/a><\/p>\n<p><strong>Chief Investigator: <\/strong><a href=\"https:\/\/research.monash.edu\/en\/persons\/suzanne-orchard\" target=\"_blank\" rel=\"noopener noreferrer\">Dr Suzanne Orchard<\/a><\/p>\n<p><strong>Publications: <\/strong><a href=\"\/usa\/publications\/\" target=\"_blank\" rel=\"noopener noreferrer\">Yes<\/a><\/p>\n<p><strong>Collaborators:\u00a0<\/strong><\/p>\n<ul>\n<li>Berman Center for Outcomes and Clinical Research (Minneapolis, MN) plus 21 centres across the USA<\/li>\n<li>Monash University<\/li>\n<li>Menzies Institute of Medical Research (TAS)<\/li>\n<li>The University of Melbourne<\/li>\n<li>Australian National University<\/li>\n<li>The University of Adelaide<\/li>\n<li>GP Associate Investigators<\/li>\n<\/ul>\n<p><strong>Funding:<\/strong><\/p>\n<ul>\n<li>National Cancer Institute\u00a0(NCI), USA<\/li>\n<li>Monash University<\/li>\n<li>Commonwealth Scientific and Industrial Research Organisation (CSIRO)<\/li>\n<\/ul>\n<p><strong>Data Access: <\/strong>Contact the relevant sub-study chief investigator or visit the\u00a0<a href=\"https:\/\/ams.aspree.org\/public\/request-data\/access-aspree-data\/\" target=\"_blank\" rel=\"noopener noreferrer\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/ams.aspree.org\/public\/request-data\/access-aspree-data\/&amp;source=gmail&amp;ust=1628580996026000&amp;usg=AFQjCNHneOadnCkDUangUdsKHocNLPhhBg\">ASPREE Access Management Site<\/a>\u00a0(AMS) before submitting an expression of interest to access sub-study data.\u00a0<strong>\u00a0<\/strong><\/p>\n<p><span style=\"font-size: 16px;font-family: 'Courier New', monospace\">Content updated: February 7, 2023<\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner admin_label=&#8221;ASPREE Cancer Treatment Study (ACTS)&#8221; module_class=&#8221;tab-content&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;840px&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column_inner saved_specialty_column_type=&#8221;2_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; header_2_font=&#8221;|600|||||||&#8221; header_2_font_size=&#8221;32px&#8221; header_2_font_size_tablet=&#8221;28px&#8221; header_2_font_size_phone=&#8221;24px&#8221; header_2_font_size_last_edited=&#8221;on|desktop&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>ASPREE Cancer Treatment Study (ACTS)<\/h2>\n<h3>A study of cancer treatment in older adults<\/h3>\n<p>[\/et_pb_text][et_pb_image src=&#8221;https:\/\/aspree.org\/wp-content\/uploads\/sites\/3\/2021\/07\/16277926.jpg&#8221; title_text=&#8221;16277926&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_text admin_label=&#8221;Caption&#8221; _builder_version=&#8221;4.19.3&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><em>The ASPREE Cancer Treatment will determine whether surviving cancer increases the risk of persistent health problems for older adults.<\/em><\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.19.3&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#000000&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><strong style=\"font-size: 16px\">Summary<\/strong><span style=\"font-size: 16px\">: Cancer is one of the most common diseases and a leading cause of death worldwide. Aging increases the risk of cancer.<\/span><\/p>\n<p>Early detection and new treatments have generally increased cancer survival. Research suggests that cancer survivors are more likely to develop persistent health problems and experience more rapid declines in cognition (thinking and memory) and functional ability than similar-aged adults who have not had cancer. It is not well understood if these increased risks are due to cancer itself, or whether the treatment, overall, or specific treatment type, plays a role.<\/p>\n<p><strong>Aim:<\/strong> To determine whether surviving cancer increases the risk of persistent diseases, such as cardiovascular disease, cognitive health and physical function.<\/p>\n<p><strong>Health Information collected:<\/strong><\/p>\n<ul>\n<li>This sub-study is undertaken entirely through examination of medical records and health information<\/li>\n<li>Involves the collection of medical\/specialist health records related to cancer treatments that ASPREE participants undertake after being diagnosed with cancer, including surgery details and therapies (such as chemotherapy and radiation)<\/li>\n<\/ul>\n<p><strong>Location:<\/strong>\u00a0USA and Australia<\/p>\n<p><strong>Status:<\/strong>\u00a0Active, not recruiting. Started in 2020, data collection continues<\/p>\n<p><strong>Chief Investigators: <\/strong>Prof John Zalcberg,\u00a0<a href=\"https:\/\/research.monash.edu\/en\/persons\/suzanne-orchard\" target=\"_blank\" rel=\"noopener noreferrer\">Dr Suzanne Orchard<\/a><\/p>\n<p><strong>Publications:\u00a0<\/strong><span style=\"font-size: 16px\">N\/A<\/span><\/p>\n<p><strong>Collaborators:\u00a0<\/strong><\/p>\n<ul>\n<li>Massachusetts General Hospital\/Harvard University<\/li>\n<li>Monash University<\/li>\n<li>Berman Center for Outcomes and Clinical Research (Minneapolis, MN) plus 21 centres across the USA<\/li>\n<li>GP Associate Investigators<\/li>\n<\/ul>\n<p><strong>Funding:<\/strong><\/p>\n<ul>\n<li>NIA &#8211; National Institute on Aging, USA<\/li>\n<\/ul>\n<p><strong>Data Access: <\/strong>Contact the relevant sub-study chief investigator or visit the\u00a0<a href=\"https:\/\/ams.aspree.org\/public\/request-data\/access-aspree-data\/\" target=\"_blank\" rel=\"noopener noreferrer\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/ams.aspree.org\/public\/request-data\/access-aspree-data\/&amp;source=gmail&amp;ust=1628580996026000&amp;usg=AFQjCNHneOadnCkDUangUdsKHocNLPhhBg\">ASPREE Access Management Site<\/a>\u00a0(AMS) before submitting an expression of interest to access sub-study data.<\/p>\n<p><span style=\"font-size: 16px;font-family: 'Courier New', monospace\">Content updated: February 7, 2023<\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner admin_label=&#8221;ASPREE D&#8221; module_id=&#8221;scroll_tab2&#8243; module_class=&#8221;tab-content&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;840px&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column_inner saved_specialty_column_type=&#8221;2_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; header_2_font=&#8221;|600|||||||&#8221; header_2_font_size=&#8221;32px&#8221; header_2_font_size_tablet=&#8221;28px&#8221; header_2_font_size_phone=&#8221;24px&#8221; header_2_font_size_last_edited=&#8221;on|desktop&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>ASPREE-D (Depression)<\/h2>\n<h3>A study of low-dose aspirin and depression in older adults<\/h3>\n<p>[\/et_pb_text][et_pb_image src=&#8221;https:\/\/aspree.org\/wp-content\/uploads\/sites\/3\/2021\/07\/halgatewood-com-uo7xJIV4Awk-unsplash.ed_.jpg&#8221; title_text=&#8221;halgatewood-com-uo7xJIV4Awk-unsplash.ed&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_text admin_label=&#8221;caption&#8221; _builder_version=&#8221;4.19.3&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><em>ASPREE-D was the first to study the effect of aspirin versus placebo on the prevention of depression in older adults.<\/em><\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.19.3&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#000000&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Summary: <\/strong>An estimated 10-15% of people aged between 70 \u2013 85 years will experience depression at some point in time. Symptoms of depression are often missed and untreated and can be mistakenly attributed to ageing and subsequently remain undetected and untreated. In older people, untreated depression is associated with a wide range of poor health outcomes, including an increased risk of dementia, social isolation, loss of quality of life and a shortened lifespan. Depression is associated with increased inflammation raising the question whether anti-inflammatory therapies might be useful for prevention or treatment of depression.<\/p>\n<p><strong>Aim: \u00a0<\/strong>Aspirin has well-known anti-inflammatory actions. With the large number of people enrolled in the ASPREE trial, for the first time, researchers in the ASPREE-D sub-study investigated whether aspirin prevented the onset of depression in older adults, or could alleviate depression in those presenting with depression.<\/p>\n<p><strong>Health Information Collected: <\/strong><\/p>\n<ul>\n<li>ASPREE participants answered questions about their history of depression and completed a measure of depression called the Center for Epidemiologic Studies Depression Scale (CES-D)-10 item scale at annual study visits. The (CES-D)-10 is a screening tool that may indicate possible depression. While only a qualified medical practitioner can make a formal diagnosis, the CESD is a reasonable proxy for diagnosis.<\/li>\n<li>Researchers will also examine blood samples in the ASPREE Biobank for the presence (or absence) of proteins or \u2018biomarkers\u2019 associated with inflammation. They will then be able to determine the relationship between these inflammatory \u2018biomarkers\u2019 in the blood and diagnosed depression. Knowing which biomarkers are associated with depression may help predict those at risk of depression or may help identify people likely to benefit from aspirin.<\/li>\n<\/ul>\n<p><strong>Location:<\/strong>\u00a0USA and Australia<\/p>\n<p><strong>Status:<\/strong> Completed.\u00a0Main\u00a0findings published (with exception of the inflammatory biomarker component)<\/p>\n<p><strong>Chief Investigator:<\/strong> <a href=\"https:\/\/www.barwonhealth.org.au\/research\/staff-categories\/item\/impact-prof-michael-berk\" target=\"_blank\" rel=\"noopener noreferrer\">Prof Michael Berk<\/a><\/p>\n<p><strong>Publications:<\/strong> <a href=\"\/usa\/publications\/\" target=\"_blank\" rel=\"noopener noreferrer\">Yes<\/a><\/p>\n<p><strong>Collaborators:<\/strong><\/p>\n<ul>\n<li style=\"font-size: 16px\">Rush University Medical Center, Department of Family Medicine and the Rush Alzheimer\u2019s Disease Center (USA)<\/li>\n<li>Monash University (Australia)<\/li>\n<li>Deakin University, School of Medicine (Australia)<\/li>\n<li>University of Melbourne, Department of Psychiatry and School of Public Health and Preventive Medicine (Australia)<\/li>\n<li>Orygen Youth Health Research Centre (Australia)<\/li>\n<li>Erasmus Medical Center, Department of Immunology (The Netherlands)<\/li>\n<li>Florey Institute of Neuroscience and Mental Health (Australia)<\/li>\n<li>GP Associate Investigators<strong>\u00a0<\/strong><\/li>\n<\/ul>\n<p><strong>Funding:<\/strong><\/p>\n<ul>\n<li>The Australian National Health and Medical Research Council (NHMRC) grant 1081901<\/li>\n<\/ul>\n<p><strong>Data Access: <\/strong>Contact the relevant sub-study chief investigator or visit the\u00a0<a href=\"https:\/\/ams.aspree.org\/public\/request-data\/access-aspree-data\/\" target=\"_blank\" rel=\"noopener noreferrer\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/ams.aspree.org\/public\/request-data\/access-aspree-data\/&amp;source=gmail&amp;ust=1628580996026000&amp;usg=AFQjCNHneOadnCkDUangUdsKHocNLPhhBg\">ASPREE Access Management Site<\/a>\u00a0(AMS) before submitting an expression of interest to access sub-study data.<\/p>\n<p><span style=\"font-size: 16px;font-family: 'Courier New', monospace\">Content updated: July 9, 2022<\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner admin_label=&#8221;ASPREE EWAS&#8221; module_id=&#8221;scroll_tab2&#8243; module_class=&#8221;tab-content&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;840px&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column_inner saved_specialty_column_type=&#8221;2_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;Text&#8221; _builder_version=&#8221;4.16&#8243; header_2_font=&#8221;|600|||||||&#8221; header_2_font_size=&#8221;32px&#8221; header_2_font_size_tablet=&#8221;28px&#8221; header_2_font_size_phone=&#8221;24px&#8221; header_2_font_size_last_edited=&#8221;on|desktop&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>ASPREE-EWAS (Epigenetics)<\/h2>\n<h3>A study of blood DNA methylation in older adults<\/h3>\n<p>[\/et_pb_text][et_pb_image src=&#8221;https:\/\/aspree.org\/wp-content\/uploads\/sites\/3\/2021\/07\/DNA-Methylation_Fin_BGweb.jpg&#8221; title_text=&#8221;DNA Methylation_Fin_BGweb&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_text admin_label=&#8221;caption&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<em>Above: An illustration of a methylation (M) pattern on our genes. The top picture represents the gene acting normally, when we are in good health. Methyl groups can act as a &#8216;stop&#8217; sign to genes associated with disease. In the lower image, the methyl groups are removed and the genes associated with a disease are switched &#8216;on&#8217;.\u00a0 <\/em><\/p>\n<p><em>The EWAS sub-study will examine how lifestyle and environmental factors, such as nutrition, physical activity, pollution and stress may change DNA methylation to switch gene function &#8216;on&#8217; or &#8216;off&#8217; over time.\u00a0<\/em><br \/>\n[\/et_pb_text][et_pb_text _builder_version=&#8221;4.19.3&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#000000&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Summary:\u00a0<\/strong>We are all born with our own individual DNA or genetic code. The genetic code is the body\u2019s blueprint, containing all the necessary information for us to grow and function. Generally, our genetic code remains relatively fixed from conception until death. However additional information in our cells helps control how our genetic code is used over a lifetime, such as when the function of a gene is switched \u2018off\u2019 or \u2018on\u2019.<\/p>\n<p dir=\"ltr\">Lifestyle and environmental factors, such as nutrition, physical activity, pollution and stress may trigger one of several epigenetic processes which can activate or deactivate gene function.\u00a0 For instance, good nutrition may influence the production of chemicals (methylation) which attach to the genetic code and \u2018turn-off\u2019 genes associated with heart problems.\u00a0 This explains how a good diet may affect heart health at a genetic level.<\/p>\n<p dir=\"ltr\">Epigenetics is still a relatively new field and much more research is needed to understand how lifestyle behaviours such as increasing exercise may alter or reverse epigenetic patterns over the short and long term.<\/p>\n<p dir=\"ltr\">Epigenetic changes are also thought to underlie certain diseases. Some of the most widely studied mechanisms of epigenetic regulation include DNA methylation (the attachment of a chemical to the genome), histone modifications and non-coding RNAs. Due to its stability and ease of measurement, DNA methylation is most commonly examined in large studies involving many individuals.<\/p>\n<p>This sub-study measures epigenome-wide DNA methylation patterns (EWAS) in blood samples donated by ASPREE participants at enrolment into the trial and three years later.<\/p>\n<p>Researchers will examine 850,000 sites for biomarkers across all genes. The DNA methylation biomarkers can be matched with participants\u2019 lifestyle, behaviours and health at the time the sample was given, and prior to future health events, such as cancer or depression, should they occur.<\/p>\n<p>The EWAS sub-study will enable researchers to use DNA methylation biomarkers to help identify older adults at risk of developing health conditions and help identify factors which may prevent or progress poor health.<\/p>\n<p><strong>Aims:\u00a0<\/strong><\/p>\n<ul>\n<li>Determine the DNA methylation patterns of individuals in the ASPREE Biobank at baseline and three-years, and contribute to ASPREE\u2019s research interests in cancer, dementia, cardiovascular disease, physical disability, depression and frailty and other conditions affecting health as we age<\/li>\n<li>Investigate how lifestyle and behaviours are associated with DNA methylation patterns and changes in patterns over time<\/li>\n<\/ul>\n<p><strong>Health Information Collected: <\/strong><\/p>\n<ul>\n<li>Blood samples provided to the ASPREE Healthy Ageing Biobank, at study recruitment and at three-years<\/li>\n<li>Relevant health, lifestyle and behaviour information provided by ASPREE participants during the course of the ASPREE trial and follow up ASPREE-XT study<\/li>\n<li>Participant health outcomes (endpoints)<\/li>\n<\/ul>\n<p><strong>Location:<\/strong>\u00a0USA and Australia<\/p>\n<p><strong>Status: <\/strong>Active, not recruiting<\/p>\n<p><strong>Chief Investigator:<\/strong> <a href=\"https:\/\/research.monash.edu\/en\/persons\/joanne-ryan\" target=\"_blank\" rel=\"noopener noreferrer\">A\/Prof Joanne Ryan<\/a><\/p>\n<p><strong>Publications: <\/strong><a href=\"https:\/\/aspree.org\/usa\/publications\/\" target=\"_blank\" rel=\"noopener noreferrer\">Yes<\/a><\/p>\n<p><strong>Collaborators:<\/strong><\/p>\n<ul>\n<li>Monash University (Australia)<\/li>\n<li>Berman Center for Outcomes and Clinical Research (Minneapolis, MN) plus 21 centres across the USA<\/li>\n<li>GP Associate Investigators<strong>\u00a0<\/strong><\/li>\n<\/ul>\n<p><strong>Funding:<\/strong><\/p>\n<ul>\n<li>Monash University<\/li>\n<li>NHMRC &#8211; The Australian National Health and Medical Research Council<\/li>\n<\/ul>\n<p><strong>Data Access: <\/strong>Contact the relevant sub-study chief investigator or visit the\u00a0<a href=\"https:\/\/ams.aspree.org\/public\/request-data\/access-aspree-data\/\" target=\"_blank\" rel=\"noopener noreferrer\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/ams.aspree.org\/public\/request-data\/access-aspree-data\/&amp;source=gmail&amp;ust=1628580996026000&amp;usg=AFQjCNHneOadnCkDUangUdsKHocNLPhhBg\">ASPREE Access Management Site<\/a>\u00a0(AMS) before submitting an expression of interest to access sub-study data.<\/p>\n<p><span style=\"font-size: 16px;font-family: 'Courier New', monospace\">Content updated: February 7, 2023<\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner admin_label=&#8221;GENOMICS&#8221; module_id=&#8221;scroll_tab2&#8243; module_class=&#8221;tab-content&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;840px&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column_inner saved_specialty_column_type=&#8221;2_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; header_2_font=&#8221;|600|||||||&#8221; header_2_font_size=&#8221;32px&#8221; header_2_font_size_tablet=&#8221;28px&#8221; header_2_font_size_phone=&#8221;24px&#8221; header_2_font_size_last_edited=&#8221;on|desktop&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>ASPREE-G (Genomics)<\/h2>\n<h3>A study of genetics on the health of older adults<\/h3>\n<p>[\/et_pb_text][et_pb_image src=&#8221;https:\/\/aspree.org\/wp-content\/uploads\/sites\/3\/2021\/07\/aspree-G-1024&#215;576-1.jpg&#8221; title_text=&#8221;aspree-G-1024&#215;576&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_text admin_label=&#8221;caption&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;]<em>Above: An illustration of the structure of DNA.<\/em><br \/>\n[\/et_pb_text][et_pb_text _builder_version=&#8221;4.20.4&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#000000&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><strong style=\"font-size: 16px\">Summary:\u00a0<\/strong><span style=\"font-size: 16px\">Genetic research is a broad term for the study of traits passed down generations through the inheritance of genetic material (such as DNA). Genetic research has an important role in medical research.<\/span><\/p>\n<p>Genes are the fundamental unit or \u2018blue-print\u2019 of life which can determine many of our physical traits such as eye colour and blood type. Genes also contribute, in combination with the environment, to more complex human traits such as personality, behaviour and the risk of developing a disease.<\/p>\n<p>Humans have approximately 20,000 genes, each gene composed of a chemical called DNA (deoxyribonucleic acid). \u00a0DNA gives the instructions or the chemical code to express traits, such as telling the body which type of protein to make and when. \u00a0These proteins form part of a complex chain of events that impact on how we look and function.<\/p>\n<p>Thanks to rapid advances in technology, an individual\u2019s entire genetic information can be studied through a process called genome sequencing. \u00a0Genome sequencing reveals more about human genetics than ever before; it also reveals large expanses of the human genome about which we know very little, if anything.<\/p>\n<p>Our health often has at least a small genetic component. \u00a0Longevity that runs in families is an example of how genes may influence good health. Genetic research is in many ways, pioneering.\u00a0 Genetic research in older adults aims to understand the role genetic make-up has on our health so that one day we may be able to better detect or prevent age-related diseases such as cancer, dementia and cardiovascular disease.<\/p>\n<p><strong>Aims:<\/strong><\/p>\n<p>Genetic studies on Biobank samples contribute to a growing body of research knowledge about genetics and health.\u00a0\u00a0 Samples in the\u00a0ASPREE Biobank\u00a0will enable researchers to better understand the role of our genes in health and ageing. Discoveries may take time to emerge, however their benefits and impact will be highly important for many years to come.<\/p>\n<p><strong>Health information collected<\/strong>:<\/p>\n<ul>\n<li>More than 15,000 ASPREE participants in the United States and Australia have generously donated blood or saliva samples for\u00a0future\u00a0biomarker or genetic research.<\/li>\n<li>Each sample contains DNA from healthy adults who have consented to genetic research (most other genetic studies look at the genes from people with disease)<\/li>\n<li>All samples are of very high quality, maximising research opportunities and are associated with unprecedented health and lifestyle information to help bridge the link between our health and what is happening at a genetic level<\/li>\n<li>Genetic studies on ASPREE Biobank samples are for\u00a0<strong><u>research purposes only\u00a0<\/u><\/strong>and are\u00a0<strong>not<\/strong>\u00a0intended to be medical investigations or diagnostic tests<\/li>\n<\/ul>\n<p><strong>Location:<\/strong>\u00a0USA and Australia<\/p>\n<p><strong>Chief Investigator:<\/strong> <a href=\"https:\/\/research.monash.edu\/en\/persons\/paul-lacaze\" target=\"_blank\" rel=\"noopener noreferrer\">A\/Prof Paul Lacaze<\/a><\/p>\n<p><strong>Genomic projects:<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p><strong>1.\u00a0 \u00a0The Medical Genome Reference Bank (MGRB) (Australia)<\/strong> \u2013 involves sequencing of 4,000 genomes from healthy people aged 75 years and over in the ASPREE study and the Sax Institute\u2019s \u201945 and Up\u2019 Study. Genetic information from the genomes will be used to form a reference bank or library of \u2018healthy genomes\u2019 of the \u2018wellderly\u2019 (well older people). The \u2018healthy\u2019 reference bank can be used as a comparison by researchers to identify, more easily, genes that cause disease.<\/p>\n<p><strong>Status:<\/strong>\u00a0Completed<\/p>\n<table width=\"1059\">\n<tbody>\n<tr>\n<td style=\"width: 345.799px\"><strong>MGRB Collaborators:<\/strong><\/td>\n<td style=\"width: 346.91px\"><strong>MGRB Funding:<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 345.799px\">\n<ul>\n<li>ASPREE Healthy Ageing Biobank<\/li>\n<li>Garvan Institute of Medical Research in Sydney<\/li>\n<li>Sax Institute\u2019s \u201945 and Up\u2019 Study<\/li>\n<\/ul>\n<\/td>\n<td style=\"width: 346.91px\">\n<ul>\n<li>NSW government<\/li>\n<li>Garvan Institute of Medical Research in Sydney<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p><strong>2.\u00a0 \u00a0 The Resilience Project<\/strong> \u2013 examines approximately 760 genes from ASPREE Biobank participants in Australia and the US for the presence of genetic variations associated with disease. The aim is to identify and understand why healthy older adults with these genetic variations remain free of disease when others do not.\u00a0 Additionally, the Resilience Project may also help reveal to ASPREE researchers genes that can reliably predict the onset of cardiovascular disease, cancer, dementia and depression in older people.<\/p>\n<p><strong>Status:<\/strong>\u00a0Completed<\/p>\n<table width=\"1061\">\n<tbody>\n<tr>\n<td style=\"width: 522.465px\"><strong>The Resilience Project Collaborators:\u00a0<\/strong><\/td>\n<td style=\"width: 523.576px\"><strong>The Resilience Project Funding:<\/strong><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 522.465px\">\n<ul>\n<li>ASPREE Healthy Ageing Biobank<\/li>\n<li>Icahn Institute at the Mount Sinai School of Medicine in New York<\/li>\n<\/ul>\n<\/td>\n<td style=\"width: 523.576px\">\n<ul>\n<li>Icahn Institute at the Mount Sinai School of Medicine in New York<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p><strong style=\"font-size: 16px\">Publications: <\/strong><a style=\"font-size: 16px\" href=\"https:\/\/aspree.org\/usa\/publications\/\" target=\"_blank\" rel=\"noopener noreferrer\">Yes<\/a><\/p>\n<p><strong>Data Access: <\/strong>Contact the relevant sub-study chief investigator or visit the\u00a0<a href=\"https:\/\/ams.aspree.org\/public\/request-data\/access-aspree-data\/\" target=\"_blank\" rel=\"noopener noreferrer\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/ams.aspree.org\/public\/request-data\/access-aspree-data\/&amp;source=gmail&amp;ust=1628580996026000&amp;usg=AFQjCNHneOadnCkDUangUdsKHocNLPhhBg\">ASPREE Access Management Site<\/a>\u00a0(AMS) before submitting an expression of interest to access sub-study data.<\/p>\n<p><span style=\"font-size: 16px;font-family: 'Courier New', monospace\">Content updated: August 8, 2021<\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner admin_label=&#8221;ALSOP&#8221; module_id=&#8221;scroll_tab2&#8243; module_class=&#8221;tab-content&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;840px&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column_inner saved_specialty_column_type=&#8221;2_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; header_2_font=&#8221;|600|||||||&#8221; header_2_font_size=&#8221;32px&#8221; header_2_font_size_tablet=&#8221;28px&#8221; header_2_font_size_phone=&#8221;24px&#8221; header_2_font_size_last_edited=&#8221;on|desktop&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>ASPREE Longitudinal Study of Older Persons (ALSOP) and the follow-up ALSOP-XT<\/h2>\n<p>[\/et_pb_text][et_pb_image src=&#8221;https:\/\/aspree.org\/wp-content\/uploads\/sites\/3\/2021\/07\/Couple-filling-in-form-e1616309367895.jpg&#8221; title_text=&#8221;Couple filling in form&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_text _builder_version=&#8221;4.19.3&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#000000&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Summary:\u00a0<\/strong> ALSOP involves a series of questionnaires to help identify factors that may have a major influence on health, independence and quality of life as we grow older. For example, difficulties with hearing or eyesight, sleep, pain or falls are common problems for some older adults and can have a real impact on quality of life. Lifestyle and social factors, such as physical activity, access to transport and social connection are also important.<\/p>\n<p>Following on from the ALSOP questionnaires completed by participants in Australia during the ASPREE trial, we are continuing to explore factors affecting the health, independence and quality of life of participants in a series of ALSOP-XT questionnaires being sent to ASPREE-XT participants in the USA and Australia.<\/p>\n<p><strong>Aim:<\/strong>\u00a0 To examine how general health, behavioural, social, economic and environmental circumstances affect health, quality of life and independence in older age.<\/p>\n<p><strong>Information collected:<\/strong><\/p>\n<p>A broad range of factors are explored including hearing, vision, dental health, pain, diet, physical activity, health service access, male and female health issues, social and community engagement, work, caring responsibilities, financial wellbeing and major life events.<\/p>\n<p>ALSOP-XT builds on information provided by participants in ALSOP and includes a few additional questions related to the COVID-19 pandemic.<\/p>\n<p><strong>Location:<\/strong>\u00a0ALSOP was conducted in Australia. ALSOP-XT questionnaires are being sent to ASPREE-XT study participants in Australia and the USA in 2021, and repeated in 2023.<\/p>\n<p><strong>Status:<\/strong>\u00a0 Active, recruiting.\u00a0Baseline, year 3 and year 5 ALSOP questionnaires have been sent and returned.<\/p>\n<p><strong>Chief Investigators:<\/strong><\/p>\n<ul>\n<li><a href=\"https:\/\/research.monash.edu\/en\/persons\/john-mcneil\" target=\"_blank\" rel=\"noopener noreferrer\">Prof John McNeil<\/a> for ALSOP questionnaires, years 1 &#8211; 5<\/li>\n<li><a href=\"https:\/\/www.dfhcc.harvard.edu\/insider\/member-detail\/member\/andrew-t-chan-md-mph\/\" target=\"_blank\" rel=\"noopener noreferrer\">Prof Andy Chan\u00a0<\/a>(USA) and <a href=\"https:\/\/research.monash.edu\/en\/persons\/robyn-woods\" target=\"_blank\" rel=\"noopener noreferrer\">A\/Prof Robyn Woods<\/a>\u00a0(Australia) for the (post ASPREE) ALSOP-XT questionnaires<\/li>\n<\/ul>\n<p><strong>Publications: <\/strong><a href=\"https:\/\/aspree.org\/usa\/publications\/\" target=\"_blank\" rel=\"noopener noreferrer\">Yes<\/a><\/p>\n<p><strong>Collaborators:\u00a0<\/strong><\/p>\n<p><strong>ALSOP-XT<\/strong><\/p>\n<ul>\n<li>Monash University<\/li>\n<li>Harvard University<\/li>\n<li>Berman Center for Outcomes and Clinical Research<\/li>\n<\/ul>\n<p><strong>Funding:<\/strong><\/p>\n<p><strong>ALSOP<\/strong><\/p>\n<ul>\n<li>Monash University<\/li>\n<li>The JO &amp; JR Wicking Trust and Mason Foundation, ANZ Trustees<\/li>\n<\/ul>\n<p><strong>ALSOP-XT<\/strong><\/p>\n<ul>\n<li>National Institutes of Health<\/li>\n<\/ul>\n<p><strong>Data Access:\u00a0<\/strong>Contact the relevant sub-study chief investigator or visit the\u00a0<a href=\"https:\/\/ams.aspree.org\/public\/request-data\/access-aspree-data\/\" target=\"_blank\" rel=\"noopener noreferrer\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/ams.aspree.org\/public\/request-data\/access-aspree-data\/&amp;source=gmail&amp;ust=1628580996026000&amp;usg=AFQjCNHneOadnCkDUangUdsKHocNLPhhBg\">ASPREE Access Management Site<\/a>\u00a0(AMS) before submitting an expression of interest to access sub-study data.<\/p>\n<p><span style=\"font-size: 16px;font-family: 'Courier New', monospace\">Content updated: August 8, 2021<\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner admin_label=&#8221;Microbiome&#8221; module_id=&#8221;scroll_tab2&#8243; module_class=&#8221;tab-content&#8221; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; max_width=&#8221;840px&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column_inner saved_specialty_column_type=&#8221;2_3&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text _builder_version=&#8221;4.16&#8243; header_2_font=&#8221;|600|||||||&#8221; header_2_font_size=&#8221;32px&#8221; header_2_font_size_tablet=&#8221;28px&#8221; header_2_font_size_phone=&#8221;24px&#8221; header_2_font_size_last_edited=&#8221;on|desktop&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h2>ASPREE-XT Microbiome Study<\/h2>\n<h3>Studying gut microbiome and health in older adults<\/h3>\n<p>[\/et_pb_text][et_pb_image src=&#8221;https:\/\/aspree.org\/wp-content\/uploads\/sites\/3\/2021\/07\/microbiome-iStock-1279892500.jpg&#8221; title_text=&#8221;microbiome iStock-1279892500&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_image][et_pb_text admin_label=&#8221;caption&#8221; _builder_version=&#8221;4.19.3&#8243; _module_preset=&#8221;default&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><em>Above: An illustration of the variety of bacteria, viruses, fungi and other microbes in our gut.<\/em><\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.20.4&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#000000&#8243; hover_enabled=&#8221;0&#8243; global_colors_info=&#8221;{}&#8221; sticky_enabled=&#8221;0&#8243;]<\/p>\n<p><strong>Summary:\u00a0\u00a0<\/strong>There is increasing evidence that our gut microbiome can play a significant role in our health and wellbeing. The gut microbiome is a collective term for trillions of bacteria, viruses, fungi and other microbes in the gut and it can be measured in a stool or \u2018poo\u2019 sample.<br \/>Aging is associated with changes in the gut microbiome, however these age-related changes in older adults are poorly understood. Previous studies have either been too small or limited to younger adults to understand the link between the types and number of microbes in the gut and its effect on good health and \/ or poor health in older persons.<\/p>\n<p><strong>Aims:\u00a0<\/strong><\/p>\n<ul>\n<li>Understand the relationship between gut microbiome, diet, and lifestyle factors and how these may contribute to good health or the development of disease, including cancer.<\/li>\n<li>Identify the gut microbiome associated with cognitive decline and dementia<\/li>\n<li>Identify the gut microbiome associated with physical disability and frailty<\/li>\n<\/ul>\n<p><strong>Health information collected<\/strong>:<\/p>\n<ul>\n<li>A small stool scraping into three tubes, collected at home<\/li>\n<li>Tongue swab the following day, collected at home<\/li>\n<li>Two brief questionnaires; one about the stool sample, diet and medication use, and the other related to the tongue swab sample and dental health<\/li>\n<li>Information about diet and lifestyle factors reported in ALSOP-XT questionnaires<\/li>\n<li>Health events collected in the ASPREE-XT longitudinal study<\/li>\n<\/ul>\n<p>Microbial DNA will be extracted from the stool samples and used to identify the types and numbers of microbes to examine if there is a link between microbe content and good health or adverse health outcomes, such as cardiovascular disease, frailty or dementia.<\/p>\n<p><strong>Location:\u00a0<\/strong>USA and Australia<\/p>\n<p><strong>Status<\/strong>: Active, recruiting. Starts in 2021, with health information collected once more in 2023<\/p>\n<p><strong>Additional information:\u00a0<\/strong><span style=\"font-size: 16px\">Microbiome information brochure and video coming soon<\/span><\/p>\n<p><strong style=\"font-size: 16px\">Principal Investigators:\u00a0 <\/strong><span style=\"font-size: 16px\"><a style=\"border-bottom-color: initial;background-color: #ffffff\" href=\"https:\/\/www.dfhcc.harvard.edu\/insider\/member-detail\/member\/andrew-t-chan-md-mph\/\" target=\"_blank\" rel=\"noopener noreferrer\">Prof Andy Chan<\/a><\/span><span style=\"font-size: 16px;background-color: #ffffff\">\u00a0(USA) and\u00a0<\/span><a style=\"font-size: 16px\" href=\"https:\/\/research.monash.edu\/en\/persons\/robyn-woods\" target=\"_blank\" rel=\"noopener noreferrer\">A\/Prof Robyn Woods<\/a><span style=\"font-size: 16px\">\u00a0(Australia)\u00a0<\/span><\/p>\n<p><strong>Manager:<\/strong> <a href=\"https:\/\/research.monash.edu\/en\/persons\/alice-owen\" target=\"_blank\" rel=\"noopener\">Dr Alice Owen<\/a> (Australia)<\/p>\n<p><strong>Publications: <\/strong>N\/A<\/p>\n<p><strong>Collaborators:\u00a0<\/strong><\/p>\n<ul>\n<li>Monash University<\/li>\n<li>Harvard Medical School<\/li>\n<\/ul>\n<p><strong>Funding:<\/strong><\/p>\n<ul>\n<li>National Institutes of Health<\/li>\n<\/ul>\n<p><strong>Data Access: <\/strong>Contact the relevant sub-study chief investigator or visit the\u00a0<a href=\"https:\/\/ams.aspree.org\/public\/request-data\/access-aspree-data\/\" target=\"_blank\" rel=\"noopener noreferrer\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/ams.aspree.org\/public\/request-data\/access-aspree-data\/&amp;source=gmail&amp;ust=1628580996026000&amp;usg=AFQjCNHneOadnCkDUangUdsKHocNLPhhBg\">ASPREE Access Management Site<\/a>\u00a0(AMS) before submitting an expression of interest to access sub-study data.<\/p>\n<p><span style=\"font-size: 16px;font-family: 'Courier New', monospace\">Content updated: February 5, 2024<\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>SUB-STUDIES Adding value to clinical research; the ASPREE project is in a unique position to lead multiple sub-studies, each investigating specific health issues affecting older adults. What is a sub-study? \u2192 View ASPREE sub-studies\u00a0 A sub-study (also known as an ancillary study) is a type of \u2018add-on\u2019 study that answers a separate research question within [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"_links":{"self":[{"href":"https:\/\/aspree.org\/usa\/wp-json\/wp\/v2\/pages\/153"}],"collection":[{"href":"https:\/\/aspree.org\/usa\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/aspree.org\/usa\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/aspree.org\/usa\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/aspree.org\/usa\/wp-json\/wp\/v2\/comments?post=153"}],"version-history":[{"count":53,"href":"https:\/\/aspree.org\/usa\/wp-json\/wp\/v2\/pages\/153\/revisions"}],"predecessor-version":[{"id":2751,"href":"https:\/\/aspree.org\/usa\/wp-json\/wp\/v2\/pages\/153\/revisions\/2751"}],"wp:attachment":[{"href":"https:\/\/aspree.org\/usa\/wp-json\/wp\/v2\/media?parent=153"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}