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ASPirin in Reducing Events in the Elderly (ASPREE) is a landmark research project to advance better health outcomes for older adults. ASPREE is comprised of an aspirin trial and a follow up health and ageing study.<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.5.1″ _module_preset=”default” custom_padding=”0px|0px|0px|0px|true|true”][et_pb_row column_structure=”1_2,1_2″ use_custom_gutter=”on” gutter_width=”1″ make_equal=”on” module_class=”custom_row” _builder_version=”4.5.1″ _module_preset=”default” background_color=”#ffffff” background_enable_image=”off” width=”100%” max_width=”100%” custom_margin=”|0px||0px|false|true” custom_padding=”0px||0px||true|false”][et_pb_column type=”1_2″ module_class=”first-on-mobile” _builder_version=”4.5.1″ _module_preset=”default” background_image=”https:\/\/aspree.org\/wp-content\/uploads\/sites\/2\/2020\/09\/027_knee-MRI_359292.jpg” background_blend=”lighten”][et_pb_code admin_label=”Image Space” _builder_version=”4.5.1″ _module_preset=”default” background_enable_image=”off” width=”100%” max_width=”100%” height=”400px”][\/et_pb_code][\/et_pb_column][et_pb_column type=”1_2″ module_class=”second-on-mobile” _builder_version=”4.5.1″ _module_preset=”default” custom_padding=”4em|5%|4em|5%|true|true” custom_padding_tablet=”2em|10%|2em|10%|true|true” custom_padding_phone=”” custom_padding_last_edited=”on|tablet” custom_css_main_element=”display: flex;||flex-direction: column;||justify-content: center;”][et_pb_text module_class=”vertical-align” _builder_version=”4.5.1″ _module_preset=”default” text_text_color=”#0c4072″ text_line_height=”1.8em” header_text_color=”#0c4072″ header_2_font=”|600|||||||” header_2_text_color=”#0c4072″ header_3_text_color=”#26619a” background_layout=”dark” custom_padding=”|10%||0px|false|false” custom_padding_tablet=”|0px||0px|true|true” custom_padding_phone=”” custom_padding_last_edited=”on|tablet” locked=”off”]<\/p>\n
This \u2018gold standard\u2019 trial \u2013 randomised, double blind, placebo-controlled trial of daily low-dose aspirin (100mg) \u2013 provided the first evidence that an aspirin a day does not prolong years of good health for ‘healthy’ older adults (those without cardiovascular disease, dementia or significant physical disability.)<\/p>\n
ASPREE was the first preventive trial to consider the effect of aspirin on disability-free life in healthy adults, aged mostly 70+ years.\u00a0<\/p>\n
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[\/et_pb_text][et_pb_button button_url=”\/aus\/for-participants\/” button_text=”participants learn more” button_alignment=”left” _builder_version=”4.5.1″ _module_preset=”22623b5b-69aa-4c59-8962-688c0b2afd23″ button_use_icon=”off” custom_margin=”5px||5px||true|false” button_bg_color__hover=”#0c4072″ button_bg_enable_color__hover=”on”][\/et_pb_button][et_pb_button button_url=”\/aus\/for-clinicians\/” button_text=”Clinicians learn more” button_alignment=”left” _builder_version=”4.5.1″ _module_preset=”22623b5b-69aa-4c59-8962-688c0b2afd23″ custom_margin=”5px||5px||true|false” button_bg_color__hover=”#0c4072″ button_bg_enable_color__hover=”on”][\/et_pb_button][et_pb_button button_url=”\/aus\/for-researchers\/” button_text=”researchers learn more” button_alignment=”left” _builder_version=”4.5.1″ _module_preset=”22623b5b-69aa-4c59-8962-688c0b2afd23″ custom_margin=”5px||5px||true|false” button_bg_color__hover=”#0c4072″ button_bg_enable_color__hover=”on”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.5.1″ _module_preset=”default” background_image=”https:\/\/aspree.org\/wp-content\/uploads\/sites\/2\/2020\/09\/Lady-swimmerweb.jpg” custom_padding=”0px|0px|0px|0px|true|true”][et_pb_row column_structure=”1_2,1_2″ use_custom_gutter=”on” gutter_width=”1″ make_equal=”on” module_class=”custom_row” _builder_version=”4.5.1″ _module_preset=”default” background_color=”#ffffff” background_enable_image=”off” width=”100%” max_width=”100%” custom_margin=”|0px||0px|false|true” custom_padding=”0px||0px||true|false”][et_pb_column type=”1_2″ module_class=”second-on-mobile” _builder_version=”4.5.1″ _module_preset=”default” custom_padding=”4em|5%|4em|5%|true|true” custom_padding_tablet=”2em|10%|2em|10%|true|true” custom_padding_phone=”” custom_padding_last_edited=”on|tablet” custom_css_main_element=”display: flex;||flex-direction: column;||justify-content: center;”][et_pb_text module_class=”vertical-align” _builder_version=”4.5.1″ _module_preset=”default” text_line_height=”1.8em” header_2_font=”|600|||||||” header_2_text_color=”#0c4072″ custom_padding=”|0px||10%|false|false” custom_padding_tablet=”|0px||0px|true|true” custom_padding_phone=”” custom_padding_last_edited=”on|desktop” locked=”off”]<\/p>\n
ASPREE and the follow-up ASPREE-XT study will determine for the first time, aspirin\u2019s short term and longer term effects on cancer, dementia and physical disability.\u00a0\u00a0ASPREE-XT will also investigate factors, such as those related to lifestyle, health behaviour, environment, genes and many others, that may be predictors of good health and longevity or predispose to age-related diseases.<\/span><\/p>\n <\/p>\n [\/et_pb_text][et_pb_button button_url=”\/aus\/for-participants\/” button_text=”participants learn more” _builder_version=”4.5.1″ _module_preset=”22623b5b-69aa-4c59-8962-688c0b2afd23″ custom_margin=”5px||5px||true|false” button_bg_color__hover=”#0c4072″ button_bg_enable_color__hover=”on”][\/et_pb_button][et_pb_button button_url=”\/aus\/for-clinicians\/” button_text=”clinicians learn more” _builder_version=”4.5.1″ _module_preset=”22623b5b-69aa-4c59-8962-688c0b2afd23″ custom_margin=”5px||5px||true|false” button_bg_color__hover=”#0c4072″ button_bg_enable_color__hover=”on”][\/et_pb_button][et_pb_button button_url=”\/aus\/for-researchers\/” button_text=”researchers learn more” _builder_version=”4.5.1″ _module_preset=”22623b5b-69aa-4c59-8962-688c0b2afd23″ custom_margin=”5px||5px||true|false” button_bg_color__hover=”#0c4072″ button_bg_enable_color__hover=”on”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_2″ module_class=”first-on-mobile” _builder_version=”4.5.1″ _module_preset=”default” background_image=”https:\/\/aspree.org\/wp-content\/uploads\/sites\/2\/2020\/09\/Lady-swimmerweb.jpg”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.5.1″ _module_preset=”default” background_color=”#26619a” custom_padding=”0px||0px||false|false”][et_pb_row _builder_version=”4.5.1″ _module_preset=”default” custom_padding=”||0px|||”][et_pb_column type=”4_4″ _builder_version=”4.5.1″ _module_preset=”default”][et_pb_text _builder_version=”4.5.1″ _module_preset=”default” header_text_color=”#ffffff” header_2_text_align=”center” header_2_text_color=”#ffffff” header_2_font_size=”32px” custom_margin=”||0px||false|false” custom_padding=”||0px||false|false”]<\/p>\n [\/et_pb_text][et_pb_slider _builder_version=”4.5.1″ _module_preset=”default” min_height=”142px” custom_margin=”-16px||||false|false” custom_padding=”||||false|false” hover_enabled=”0″][et_pb_slide heading=”ASPREE Project Journey” image=”https:\/\/aspree.org\/wp-content\/uploads\/sites\/2\/2021\/07\/Participantinfrontofbus.jpg” _builder_version=”4.5.1″ _module_preset=”default”]<\/p>\n A series of curated images marking major project milestones<\/p>\n [\/et_pb_slide][et_pb_slide heading=”October 2009 ” image=”https:\/\/aspree.org\/wp-content\/uploads\/sites\/2\/2021\/04\/091001-ASPREE-launch-4346_232240-Small.jpg” _builder_version=”4.5.1″ _module_preset=”default”]<\/p>\n Prof John McNeil announces NIA funding for the world-first ASPREE Clinical Trial, a multi-site, bi-national primary prevention aspirin trial in older adults.<\/p>\n [\/et_pb_slide][et_pb_slide heading=”February 2010″ image=”https:\/\/aspree.org\/wp-content\/uploads\/sites\/2\/2021\/05\/Biobank-launch-csiro-2010.jpg” _builder_version=”4.5.1″ _module_preset=”default”]<\/p>\n ASPREE investigators launch in Melbourne,\u00a0 the CSIRO-funded ASPREE Healthy Ageing Biobank, a world-first ‘bank’ of biospecimens from healthy older Australians.<\/p>\n [\/et_pb_slide][et_pb_slide heading=”March 2010″ image=”https:\/\/aspree.org\/wp-content\/uploads\/sites\/2\/2021\/05\/ASPREE-Launch-gov-house.jpg” _builder_version=”4.5.1″ _module_preset=”default”]<\/p>\n Governor of Victoria, Prof David de Krester, Prof John McNeil (ASPREE) and Prof Peter Mudge (Royal Australian College of General Practitioners), launch the ASPREE Clinical Trial at Government House, Melbourne.<\/p>\n [\/et_pb_slide][et_pb_slide heading=”August 2010″ image=”https:\/\/aspree.org\/wp-content\/uploads\/sites\/2\/2021\/05\/BendigoLaunch8-2-scaled.jpg” _builder_version=”4.5.1″ _module_preset=”default”]<\/p>\n The future Victorian premier, Daniel Andrews, local MP, Jacinta Allan and Prof John McNeil launch the ASPREE Clinical Trial Centre in Bendigo.<\/p>\n Members of the Bendigo team conduct study activity in central Victoria.<\/p>\n [\/et_pb_slide][et_pb_slide heading=”December 2010″ image=”https:\/\/aspree.org\/wp-content\/uploads\/sites\/2\/2021\/05\/IMG_0081.jpg” _builder_version=”4.5.1″ _module_preset=”default”]<\/p>\n The ASPREE Clinical Trial Centre in Traralgon, Victoria opens.<\/p>\n Members of the Traralgon team travel to Bairnsdale, Paynesville, and south-west Gippsland.<\/p>\n [\/et_pb_slide][et_pb_slide heading=”March 2011″ image=”https:\/\/aspree.org\/wp-content\/uploads\/sites\/2\/2021\/06\/IMG_2127-scaled.jpg” _builder_version=”4.5.1″ _module_preset=”default”]<\/p>\n ASPREE launches a Clinical Trial Centre in Ballarat, Victoria.<\/p>\n Members of the Ballarat ASPREE team conduct study activity in and around the Goldfields region.<\/p>\n [\/et_pb_slide][et_pb_slide heading=”March 2011″ image=”https:\/\/aspree.org\/wp-content\/uploads\/sites\/2\/2021\/06\/ASPREEGeelonglaunch-scaled.jpg” _builder_version=”4.5.1″ _module_preset=”default” hover_enabled=”0″]<\/p>\n Vale Frank Costa, Geelong personality and philanthropist, who helped launch the ASPREE Clinical Trial Centre in his regional city.<\/p>\n Members of the Geelong team conduct study activity in the greater Geelong and Bellarine Peninsula areas.<\/p>\n [\/et_pb_slide][et_pb_slide heading=”June 2011″ image=”https:\/\/aspree.org\/wp-content\/uploads\/sites\/2\/2021\/06\/Warrnambool-launchedited.jpg” _builder_version=”4.5.1″ _module_preset=”default”]<\/p>\n Victorian Minister, Dr Denis Napthine MP, attends the launch of the Warrnambool ASPREE Clinical Trial Centre.\u00a0 Members of the Warrnambool team conduct study activity across south-western parts of Victoria, including Hamilton, Port Fairy and Portland and in Mount Gambier, SA.<\/p>\n [\/et_pb_slide][et_pb_slide heading=”February 2012″ image=”https:\/\/aspree.org\/wp-content\/uploads\/sites\/2\/2021\/06\/ASPREE-northern-suburbs-launch2012.jpg” _builder_version=”4.5.1″ _module_preset=”default”]<\/p>\n ASPREE begins recruiting residents living in Melbourne’s northern suburbs into the trial.<\/p>\n [\/et_pb_slide][et_pb_slide heading=”August 2012″ image=”https:\/\/aspree.org\/wp-content\/uploads\/sites\/2\/2021\/07\/Wodonga-lauch.jpg” _builder_version=”4.5.1″ _module_preset=”default”]<\/p>\n ASPREE launches the Wodonga Clinical Trial Centre.<\/p>\n Members of the Wodonga ASPREE team conduct study activities in north-east Victoria and and southern NSW.<\/p>\n [\/et_pb_slide][et_pb_slide heading=”September 2012″ image=”https:\/\/aspree.org\/wp-content\/uploads\/sites\/2\/2021\/06\/ASPREEAdelaideLaunch2012-scaled.jpg” _builder_version=”4.5.1″ _module_preset=”default”]<\/p>\n Federal Minister,\u00a0 Hon Mark Butler MP, launches the Adelaide ASPREE Clinical Trial Centre housed at Adelaide University.<\/p>\n Members of the Adelaide ASPREE team conduct study activities in Adelaide and Victor Harbour.<\/p>\n [\/et_pb_slide][et_pb_slide heading=”April 2013″ image=”https:\/\/aspree.org\/wp-content\/uploads\/sites\/2\/2021\/07\/mildura_launch_new.jpg” _builder_version=”4.5.1″ _module_preset=”default”]<\/p>\n The ASPREE Clinical Trial is officially launced in Mildura.<\/p>\n Members of the ASPREE Melbourne field team regularly travel to Mildura to conduct study activity.<\/p>\n [\/et_pb_slide][et_pb_slide heading=”October 2013″ image=”https:\/\/aspree.org\/wp-content\/uploads\/sites\/2\/2021\/06\/John-Ros-Wilf-2013-scaled.jpg” _builder_version=”4.5.1″ _module_preset=”default”]<\/p>\n ASPREE launches a Clinical Trial Centre in Wollongong.<\/p>\n The Wollongong team conduct study activities in the Wollongong, Shellharbour and Nowra regions.<\/p>\n [\/et_pb_slide][et_pb_slide heading=”October 2014″ image=”https:\/\/aspree.org\/wp-content\/uploads\/sites\/2\/2021\/06\/CPatronoAspirin-Ca-symposium20Oct2014.jpg” _builder_version=”4.5.1″ _module_preset=”default”]<\/p>\n International aspirin researcher, Prof Carlo Patrono, gives a key note address at an aspirin and cancer symposium,\u00a0 hosted by Monash University and the CSIRO.<\/p>\n [\/et_pb_slide][et_pb_slide heading=”December 2014″ image=”https:\/\/aspree.org\/wp-content\/uploads\/sites\/2\/2021\/04\/Aust-map-e1429842972950-1.png” _builder_version=”4.5.1″ _module_preset=”default”]<\/p>\n Recruitment phase of the ASPREE Clinical Trial closes with 19,114 participants:<\/p>\n [\/et_pb_slide][et_pb_slide heading=”May 2015″ image=”https:\/\/aspree.org\/wp-content\/uploads\/sites\/2\/2021\/06\/Biorepositorylaunch2015.jpg” _builder_version=”4.5.1″ _module_preset=”default” hover_enabled=”0″]<\/p>\n Prof Christina Mitchell, Dean of the Monash Faculty of Medicine, Nursing and Health Sciences, and visiting Co-Principal Investigator of the ASPREE trial in the USA, Prof Richard Grimm, officially open the Monash University Biorepository in Melbourne.<\/p>\n [\/et_pb_slide][et_pb_slide heading=”May 2015″ image=”https:\/\/aspree.org\/wp-content\/uploads\/sites\/2\/2021\/06\/Biobanksamples-rotated.jpg” _builder_version=”4.5.1″ _module_preset=”default”]<\/p>\n The ASPREE Healthy Ageing Biobank, an ASPREE sub-study, stores baseline blood and urine samples from 12,220 ASPREE participants.<\/p>\n Samples are stored in the newly constructed Monash Biorepository.<\/p>\n [\/et_pb_slide][et_pb_slide heading=”June 2017″ image=”https:\/\/aspree.org\/wp-content\/uploads\/sites\/2\/2021\/06\/ASPREE-study-med-bottle-2015.jpg” _builder_version=”4.5.1″ _module_preset=”default”]<\/p>\n The intervention period of the ASPREE Clinical Trial closes.\u00a0<\/p>\n All participants return study tablets for a final count by members of the ASPREE team. Most continue in the follow-up study, ASPREE-XT (eXTension).<\/p>\n [\/et_pb_slide][et_pb_slide heading=”September 2018″ image=”https:\/\/aspree.org\/wp-content\/uploads\/sites\/2\/2020\/09\/aspirininhand-3.jpg” video_url=”http:\/\/https:\/\/youtu.be\/BkdQs3z_hrM” _builder_version=”4.5.1″ _module_preset=”default”]<\/p>\n ASPREE results are published in 3 separate papers in the New England Journal of Medicine<\/em> and announced world-wide.<\/p>\n ASPREE advises participants and their GPs of the findings and notifies them of their assigned (aspirin or placebo) study tablet.<\/p>\n [\/et_pb_slide][et_pb_slide heading=”May 2019″ image=”https:\/\/aspree.org\/wp-content\/uploads\/sites\/2\/2021\/07\/016-TrialoftheYear2019-20May19-20May19-1024×683-1.jpg” _builder_version=”4.5.1″ _module_preset=”default”]<\/p>\n The Australian Clinical Trials Alliance (ACTA) awards ASPREE the ‘Clinical Trial of the Year<\/em>‘ for its significance to the healthcare of older adults.<\/p>\n ASPREE Executive Officer, A\/Prof Robyn Woods accepted the award on behalf of the team of ASPREE researchers and support staff.<\/p>\n [\/et_pb_slide][et_pb_slide heading=”June 2019″ image=”https:\/\/aspree.org\/wp-content\/uploads\/sites\/2\/2021\/07\/IMG_4847-1024×770-1.jpg” _builder_version=”4.5.1″ _module_preset=”default”]<\/p>\n ASPREE Principal Investigator, Prof John McNeil accepts the Alfred Research Alliance ‘Highest Impact Factor for Publications<\/em>‘ award.<\/p>\n In 2018, the prestigious New England Journal of Medicine took the unusual step of publishing 3 separate papers of ASPREE findings at the same time.<\/p>\n [\/et_pb_slide][et_pb_slide heading=”August 2019″ image=”https:\/\/aspree.org\/wp-content\/uploads\/sites\/2\/2021\/06\/ASPREE-XT-Logo-2019-2.png” _builder_version=”4.5.1″ _module_preset=”default”]<\/p>\n The US National Institute of Aging (NIA) funds the follow-up ASPREE-XT study in Australia and the USA until 2024.<\/p>\n [\/et_pb_slide][\/et_pb_slider][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.5.1″ _module_preset=”default” min_height=”100px” height=”100px” max_height=”100px” custom_margin=”-1px||-1px||false|false” custom_padding=”0px||0px||false|false” locked=”off”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.5.1″ _module_preset=”default”][et_pb_column type=”1_2″ _builder_version=”4.5.1″ _module_preset=”default”][et_pb_text _builder_version=”4.5.1″ _module_preset=”default”]<\/p>\n Page updated: 1 March 2021<\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.5.1″ _module_preset=”default”][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Overview of world-first ASPREE research comprised of the ASPREE clinical aspirin trial and the follow up ASPREE-XT longitudinal health study of older adults. <\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"_links":{"self":[{"href":"https:\/\/aspree.org\/aus\/wp-json\/wp\/v2\/pages\/1842"}],"collection":[{"href":"https:\/\/aspree.org\/aus\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/aspree.org\/aus\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/aspree.org\/aus\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/aspree.org\/aus\/wp-json\/wp\/v2\/comments?post=1842"}],"version-history":[{"count":186,"href":"https:\/\/aspree.org\/aus\/wp-json\/wp\/v2\/pages\/1842\/revisions"}],"predecessor-version":[{"id":8676,"href":"https:\/\/aspree.org\/aus\/wp-json\/wp\/v2\/pages\/1842\/revisions\/8676"}],"wp:attachment":[{"href":"https:\/\/aspree.org\/aus\/wp-json\/wp\/v2\/media?parent=1842"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}ASPREE’S HISTORY<\/h1>\n
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